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Sponge calcium alginate medical dressing, and preparation method

A technology of calcium alginate and sodium alginate, applied in the field of medicine, can solve the problems of lack of elasticity of calcium alginate sponge, difficult to use in the field of medical dressings, difficult to apply medical dressings, etc. and low production cost

Active Publication Date: 2011-11-30
山东康康新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires secondary freezing, complex process and high energy consumption, and the obtained calcium alginate sponge has a dense, hard and inelastic structure, which is only suitable for tissue engineering scaffolds and is difficult to apply in the field of medical dressings
In addition, Hao Xiaoli et al. (Preparation and water absorption performance of two kinds of calcium alginate membranes, Polymer Materials Science and Engineering, 2010 No. 4, 143-145) reported that a calcium alginate sponge was obtained using a freeze-drying technique. Although it reduces energy consumption and simplifies the process, the sponge structure produced by the secondary freeze-drying process is denser, less elastic and flexible, and more difficult to use in the field of medical dressings

Method used

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preparation example Construction

[0029] A kind of preparation method of calcium alginate sponge medical dressing, the preparation method of calcium alginate sponge medical dressing comprises the steps:

[0030] a Preparation of sodium alginate blend solution

[0031] Weigh low-molecular-weight sodium alginate according to 4.2% to 5.4% of the mass of distilled water, and add it to distilled water to stir and dissolve evenly to obtain a solution of low-molecular-weight sodium alginate, and then weigh it according to 0.6% to 1.8% of the mass of distilled water High-molecular-weight sodium alginate is added to the above solution, and stirred at room temperature until it dissolves uniformly to obtain a sodium alginate blend solution.

[0032]The present invention adopts two kinds of sodium alginates with large difference in molecular weight as raw materials to prepare a blended solution. The low molecular weight sodium alginate can ensure that the sponge has a suitable solid content, thereby having more pore struc...

Embodiment 1

[0044] Weigh 100 grams of distilled water, 4.2 grams of sodium alginate with a molecular weight of 50,000, and 1.8 grams of sodium alginate with a molecular weight of 300,000, and add the two raw materials of sodium alginate to the distilled water sequentially while stirring, and stir at room temperature until dissolved , to obtain a blended solution of sodium alginate; place the blended solution in a low-temperature constant temperature device, and lower the temperature while mechanically stirring at 0°C, stop stirring when the solution is cooled to 0°C, dispense it into a mold, and place the mold at an ultra-low temperature Pre-freeze in the refrigerator, pre-freeze at -80°C for 1 hour, then place the mold in a freeze dryer, control the vacuum degree during the drying process to be below 20Pa, treat it at -50°C for 6 hours, and demould after drying to obtain shaped alginic acid Sodium sponge; Weigh 100 grams of ethanol, 2 grams of polyethylene glycol, and 3 grams of calcium c...

Embodiment 2

[0046] Weigh 100 grams of distilled water, 5.4 grams of sodium alginate with a molecular weight of 10,000, and 0.6 grams of sodium alginate with a molecular weight of 500,000, and add the two raw materials of sodium alginate to the distilled water sequentially while stirring, and stir at room temperature until dissolved , to obtain a blended solution of sodium alginate; put the blended solution in a low-temperature constant temperature device, and lower the temperature while mechanically stirring at 0°C, stop stirring when the solution is cooled to 1°C, dispense it into a mold, and place the mold at an ultra-low temperature Pre-freeze in the refrigerator, pre-freeze at -10°C for 5 hours, then place the mold in a freeze dryer, control the vacuum degree during the drying process to be below 20Pa, treat it at -20°C for 36 hours, and demould after drying to obtain shaped alginic acid Sodium sponge; successively weigh 100 grams of ethanol, 3 grams of glycerol, and 4 grams of calcium...

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Abstract

The invention discloses a sponge calcium alginate medical dressing and a preparation method thereof and belongs to the technical field of medicines. The sponge calcium alginate medical dressing is formed by the following steps of: performing freeze drying on blended solution of sodium alginates with different molecular weights and forming, crosslinking and curing by using calcium ions and treating by using a softening agent. The sponge calcium alginate medical dressing has high flexibility, elasticity, air permeability, abrasive resistance, water absorption, biocompatibility and degradability a good barrier property, and the function of stopping bleeding, is easy to remove, has a flat and crackless surface, can substitute a sponge calcium alginate nonwoven medical dressing, can be used for treating various skin traumas such as wounds, wound surfaces of burns, and the like, prevents bacterial infection, promotes tissue repair and accelerates wound heating. Compared with the sponge calcium alginate nonwoven medical dressing, the sponge calcium alginate medical dressing has the advantages of simple production process, low cost and the like and helps to reduce the medical cost of a patient.

Description

technical field [0001] The invention relates to a calcium alginate sponge medical dressing and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The skin has important functions such as resisting the invasion of pathogenic bacteria outside the body, excreting human waste, preventing the evaporation of water in the human body, regulating the temperature of the human body, and feeling the stimulation of pressure, cold and temperature. When the skin is damaged due to trauma, abrasions, burns, and ulcers, it is easy to be infected with bacteria, or fluid loss occurs and cause various complications. Therefore, medical dressings are required to protect the wound and promote wound healing during treatment. The traditional medical dressing (gauze) only plays the role of covering the wound surface. With the development of society and the advancement of science and technology, especially the rapid development of modern medicine, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
Inventor 张传杰朱平熊春华赵瑾朝刘云
Owner 山东康康新材料科技有限公司
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