Preparation method and application of zwitterion water gel dressing

Abstract

The invention relates to a preparation method and application of zwitterion water gel dressing. According to the preparation method, zwitterion monomers, cross linking agents, initiators, sodium chloride and distilled water are uniformly mixed according to the ingredient content; a glass slide is used for preparing templates; a polyfluortetraethylene pad is clamped between two glass slides, and a gap is then formed there; gauze is cut into the proper size to be clamped between the glass slides; then, a uniformly mixed reaction solution is dripped into the template gap; through crosslinking reaction, the zwitterion water gel modified gauze dressing can be obtained. Identically, during the preparation of a zwitterion water gel woundplast, the zwitterion water gel modified woundplast dressing can be obtained through the crosslinking reaction. The water gel dressing provided by the invention has the advantages that the water content is high, so that the wound is in a moist environment; meanwhile, the water absorption capability is high, and the secreted body fluid can be absorbed at any time, so that no excessive pyema exists in the wound position; high biocompatibility is realized; the problems of skin allergy inflammation and the like cannot be caused; the fast heeling of the wound can be promoted.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a superhydrophilic zwitterionic hydrogel dressing and its application in raw materials for wound healing such as burns, scalds, cuts and contusions. Background technique [0002] Skin injuries are one of the most common physical injuries in everyday life. According to incomplete statistics, millions of patients are injured every year due to burns, scalds, car accidents, surgical operations, etc., or suffer from infection and death due to inadequate treatment of wounds. Therefore, research on wound treatment methods and wound dressings has been receiving much attention. The traditional wound treatment method is to use gauze, a commonly used dry wound dressing, to keep the wound dry and promote scab formation. This healing method is called dry healing. However, studies have found that there are many defects in dry healing: 1) it is easy to d...

AI Technical Summary

Problems solved by technology

However, studies have found that there are many defects in dry healing: 1) it is easy to dehydrate the wound, forming dry scab, which hinders the migration of epithelial cells; 3) The interstitial fluid leaks fast, and the dressing needs to be changed frequently, so that it is impossible to maintain a stable humidity around the wound, so that the proliferation of cells slows down and the healing time is prolonged; 4) The wound surface and There is no barrier to the outside world, which cannot effectively prevent the invasion of bacteria

Many new moist dressings have emerged, such as hydrocolloid dressings, alginate dressings, foam dressings, film dressings, etc., but at present, none of the dressings can meet the requirements of an ideal dressing: 1) Breathable and moisture-permeable, so that the wound is Moist but no effusion environment; 2) soft texture, fits well with the wound without sticking to the wound; 3) can form a barrier to prevent bacterial invasion and prevent infection; 4) has good biocompatibility, can promote wound healing fast healing

For example, the mechanical properties of hydrocolloid dressings are too poor, and they are easy to break; alginate dressings do not adhere well to the wound surface, and are easy to adhere to the wound; foam dressings can easily cause tissue to grow into the foam pores and cause retrauma. And it will leave residues on the wound surface; the water vapor transmission rate of the film dressing is too low, and the air permeability is poor

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