Biodegradable cryogel dressing as well as preparation method and application thereof

A biodegradable, gelatinous technology, applied in the field of biomedical materials, can solve the problems of hemostatic materials that cannot be used, massive bleeding, and incompressibility, and achieve the effects of avoiding secondary bleeding and pain, promoting vascularization, and being easy to store

Active Publication Date: 2020-11-10
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings of the above-mentioned prior art, the object of the present invention is to provide a biodegradable gel dressing and its preparation method and application, so as to solve the problem that existing hemostatic materials cannot be used for deep, narrow and non-compressible hemorrhage technical problems with fatal profuse bleeding

Method used

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  • Biodegradable cryogel dressing as well as preparation method and application thereof
  • Biodegradable cryogel dressing as well as preparation method and application thereof
  • Biodegradable cryogel dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Preparation of GT25 / DA0 crystal gel dressing: adding gelatin (GT) to deionized water to configure a 5.0wt% GT solution; adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride (EDC hydrochloride) was added to deionized water to configure a 75mg / mL EDC solution; N-hydroxysuccinimide (NHS) was added to deionized water to configure a 45mg / mL NHS solution; subsequently, Place the GT solution, EDC solution, NHS solution and deionized water in an ice-water mixing bath to fully pre-cool and then fully mix to obtain a final concentration of GT of 2.5wt%, wherein the amino groups on the gelatin, EDC and NHS and the molar The ratio was 1:0.5:0.5, and then the mixture was placed in a low-temperature reactor at -12°C for 36 hours. After the reaction, the crystal gel dressing was thawed, dialyzed in deionized water for 1 day, and freeze-dried at -80°C to obtain the biodegradable crystal gel dressing GT25 / DA0.

Embodiment 2

[0054] Preparation of GT25 / DA2 crystal gel dressing: adding gelatin to deionized water to configure 5.0wt% GT solution; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Add to deionized water to make 75mg / mL EDC solution; add N-hydroxysuccinimide to deionized water to make 45mg / mL NHS solution; add dopamine hydrochloride to deionized water to make 100mg / mL DA solution; sodium periodate was added to deionized water to form a 37.6 mg / mL SP solution; subsequently, GT solution, EDC solution, NHS solution, DA solution, SP solution and deionized water were placed in an ice-water mixing bath Fully pre-cooled and then fully mixed to obtain a final concentration of GT of 2.5wt%, a final concentration of DA of 2.0mg / mL, wherein, the molar ratio of the amino group on the gelatin, EDC and NHS is 1:0.5:0.5, periodate The molar ratio of sodium to dopamine is 1:1. Then the mixture was placed in a low-temperature reactor at -12°C for 36 hours of reaction. After the reaction, the ...

Embodiment 3

[0056] The final concentration of DA in Example 2 is controlled at 4.0mg / mL, 6.0mg / mL, 8.0mg / mL and 10.0mg / mL respectively, and other conditions are the same as in Example 2, and the biodegradable gel dressing GT25 can be obtained respectively / DA4, GT25 / DA6, GT25 / DA8 and GT25 / DA10.

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Abstract

The invention discloses a biodegradable cryogel dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. Amino compounds are selected as main components, and the selected amino compounds have good biocompatibility and can be degraded in organisms. Therefore, the amidation reaction of amino and carboxyl in the amino compound is catalyzed by EDC hydrochloride and NHS to form a basic network structure of the cryogel. The cryogel dressing is holes communicating with each other in a free state, compared with the cryogel dressing in a shape free state, the cryogel dressing in a shape fixed state is a collapsed and closed hole, but a cryogel dressing sample still keeps an undamaged network structure. The preparation method disclosed by the invention is simple and low in cost, the biodegradable cryogel dressing is easy to carry and biodegradable, and the prepared cryogel dressing can be used for quickly stopping bleeding andhas huge potential in serving as a novel hemostatic for promoting wound healing.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a biodegradable crystal gel dressing and a preparation method and application thereof. Background technique [0002] The occurrence of wars, traffic accidents and natural disasters can easily lead to bleeding in the human body. It has been reported that more than 30% of traumatic deaths worldwide are due to excessive blood loss. Therefore, hemostatic agents with rapid hemostasis are essential for the treatment of severe traumatic bleeding. Although existing hemostatic materials such as cyanoacrylates, glutaraldehyde-crosslinked albumin, zeolite-based QuickClot, or fibrin-based bandages have high hemostatic efficiencies, they often fail to stop deep or narrow wounds , Incompressible bleeding. In particular, surgical sutures are the only clinically available wound closure to stop aortic hemorrhage, which is difficult to apply in emergency situations. [0003] Further...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61K38/14A61K31/65A61K31/137A61K41/00A61K9/06A61P7/04A61P17/02A61P31/02A61P31/04A61P39/06C08J3/24C08J9/28
CPCA61K9/0019A61K9/06A61K31/137A61K31/65A61K38/14A61K41/0052A61L26/0004A61L26/0023A61L26/0038A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L26/009A61L2300/404A61L2300/406A61L2300/412A61L2300/418A61L2300/602A61L2400/04A61L2400/06A61P7/04A61P17/02A61P31/02A61P31/04A61P39/06C08J3/246C08J9/28C08J2389/00C08L5/08C08L5/04A61K2300/00
Inventor 郭保林黄颖赵鑫
Owner XI AN JIAOTONG UNIV
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