Preparation method of viscoelastic agent with cohesiveness and dispersivity

Abstract

Single cohesiveness or dispersivity cannot simultaneously satisfy different needs in the whole cataract surgery. Chitosan and sodium hyaluronate respectively belong to natural polycation and polyanion polysaccharides. Through charge interaction between chitosan and sodium hyaluronate, a polyelectrolyte complex is formed and the polyelectrolyte complex is processed to form the viscoelastic agent with cohesiveness and dispersivity. Medical chitosan gel has thermolability and after moist heat sterilization, the molecular weight of the chitosan gel is reduced and dispersivity is improved so that the chitosan gel can prevent corneal tissue mechanical damage. After positive and negative charge interaction, ionic crosslinked compound gel still has good cohesiveness, still has typical non-Newton rheological behavior and can be removed easily and reduce residual in eyes. Cohesiveness and dispersivity guarantees that a single product can satisfy demands in different stages in the whole cataract surgery and has a wide clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a method for preparing a viscoelastic agent with both cohesive and dispersible properties. Combined to form a viscoelastic agent with both cohesive and diffusive properties, it provides an ideal biomedical material for the whole process of cataract surgery. Background technique [0002] Cataract has been a common ophthalmic disease for a long time, and cataract is the leading cause of blindness in both developed and developing countries. With the aging society in various countries, the incidence of cataract and ophthalmic diseases is also increasing. Medical surgery is the most effective means to restore the eyesight of cataract patients. In recent years, with the development and maturity of microsurgical technology, ultrasound Emulsification cataract surgery has become the mainstream of cataract and ophthalmic surgery at home and abroad because of its small surgica...

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Problems solved by technology

However, the single use of dispersible viscoelastic agents also has major problems, mainly because the products have low molecular weight and low elasticity but cannot meet the preoperative filling and supporting functions. After that, it cannot be completely sucked out from the eye, resulting in complications such as increased intraocular pressure caused by residue in the eye

[0004] It can be seen that a single dispersive or cohesive viscoelastic agent cannot achieve a very ideal use effect, so it is necessary to develop an ophthalmic viscoelastic agent with both dispersible and cohesive properties, and combine the respective advantages of the two to achieve It not only has good filling and supporting functions, but also has good intraocular clearance properties

There is no such product on the market so far

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