Slow-release disinfection gel, preparation method and application thereof

A disinfection gel and sustained-release technology, applied in the field of biomedical materials, can solve the problems of limited application scope and fixed dosage, and achieve the effects of wide application scope, diverse use occasions, and excellent antibacterial effect.

Pending Publication Date: 2022-02-11
杭州易沃科信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the usage and dosage of hypochlorous acid in the gel state are relatively fixed at present, and the scope of application is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The present embodiment provides a slow-release hypochlorous acid hydrogel, according to the following method:

[0035] The first step is to prepare bionic-based high-purity hypochlorous acid water;

[0036]The preparation method of bionic high-purity hypochlorous acid disinfection water, the configuration amount m of the immobilized methyl rhenium trioxide catalyst is 800mg, the mass concentration of hydrogen peroxide is 3%, and the mass concentration of sodium chloride is 6%. The mass concentration of hydrochloric acid is 0.3%. The mixing ratio of purified water: hydrogen peroxide: sodium chloride: hydrochloric acid is 200:0.5:1:0.15. The catalytic reaction was carried out at room temperature. After the reaction, the content of hypochlorous acid was measured by DPD spectrophotometry, and the content of hypochlorous acid reached 205.6mg / L; the pH value was measured with a portable pH meter, and the pH value was 5.78.

[0037] In the second step, high-purity hypochloro...

Embodiment 2

[0040] This embodiment provides a bionic-based high-purity hypochlorous acid hydrogel, the preparation method of which is the same as that of Embodiment 1, wherein the configuration amount m of the immobilized methyl rhenium trioxide catalyst is 1000 mg, and the mass of hydrogen peroxide is used The concentration is 3%, the mass concentration of sodium chloride is 6%, and the mass concentration of hydrochloric acid is 0.3%. The mixing ratio of purified water: hydrogen peroxide: sodium chloride: hydrochloric acid is 600:0.5:1:0.1. The catalytic reaction was carried out at room temperature. After the reaction, the content of hypochlorous acid was measured by DPD spectrophotometry, and the content of hypochlorous acid reached 59.2mg / L; the pH value was measured with a portable pH meter, and the pH value was 5.98.

[0041] Hypochlorous acid hydrogel, in terms of mass percentage, the proportion of each raw material in its preparation components is: hypochlorous acid water 96.55%, a...

Embodiment 3

[0043] This embodiment provides a bionic-based high-purity hypochlorous acid hydrogel, the preparation method of which is the same as that of Embodiment 1, wherein the configuration amount m of the immobilized methyl rhenium trioxide catalyst is 1000 mg, and the mass of hydrogen peroxide is used The concentration is 3%, the mass concentration of sodium chloride is 6%, and the mass concentration of hydrochloric acid is 0.3%. The mixing ratio of purified water: hydrogen peroxide: sodium chloride: hydrochloric acid is 300:0.5:1:0.1. The catalytic reaction was carried out at room temperature. After the reaction, the content of hypochlorous acid was measured by DPD spectrophotometry, and the content of hypochlorous acid reached 16.9 mg / L; the pH value was measured with a portable pH meter, and the pH value was 6.04.

[0044] Hypochlorous acid hydrogel, in terms of mass percentage, the proportion of each raw material in its preparation components is: hypochlorous acid water 98%, alk...

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Abstract

The invention discloses slow-release disinfection gel, a preparation method and application thereof, and belongs to the technical field of biomedical materials. High-purity hypochlorous acid water is prepared by imitating a generation mode of hypochlorous acid in human neutrophil, and the hypochlorous acid hydrogel is prepared by taking the hypochlorous acid water as a main raw material, taking a mixture of sodium magnesium fluosilicate and magnesium fluosilicate as gel, taking hydrochloric acid or alkaline electrolyzed water as a pH regulator and taking acetic acid and sodium acetate as pH buffering agents. If necessary, sodium chloride can be added as an isotonic agent, sodium hyaluronate can be added as a humectant, and poloxamer can be added as a hemostatic. According to the gel disclosed by the invention, the high-purity hypochlorous acid water is taken as a main raw material, particularly the mixture of the sodium magnesium fluosilicate and the magnesium fluosilicate is taken as the gel agent, and the invention has good tissue adhesion, biocompatibility and swelling property and has the advantages of long-acting slow-release bacterium killing, adjustable formula and wide application range.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, and relates to disinfection care, in particular to a slow-release disinfection gel, a preparation method and an application thereof. Background technique [0002] The human immune system can resist the invasion of external pathogens, largely because the immune system produces highly active chemical substances, such as reactive oxygen species (ROS), to produce an effective and rapid bactericidal response. Mitochondrial membrane-bound reduced coenzyme II (hereinafter referred to as NADPH) is the main enzyme for ROS production. During neutrophil activation, respiration produces hydrogen peroxide (H 2 o 2 ), while the activated myeloperoxidase (MPO) in Cl - and H + In the presence of H 2 o 2 Converted to hypochlorous acid (HOCl). [0003] Quantitative analysis results show that within 2 hours of incubation, 100,000 activated neutrophils can produce about 2×10 -7 mol of hypochloro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K33/20A61K33/16A61K31/19A61P15/00A61P31/02A61P17/00A61P31/10A61P17/10A61P27/02A61K8/20A61K8/25A61K8/36A61Q11/00A61L26/00C01B11/04
CPCA61K9/06A61K33/20A61K33/16A61K31/19A61P15/00A61P31/02A61P17/00A61P31/10A61P17/10A61P27/02A61K8/20A61K8/25A61K8/36A61Q11/00A61L26/0004A61L26/008A61L26/0066A61L26/0061C01B11/04A61L2300/404A61L2300/412A61K2300/00
Inventor 李世通陈仲敏叶章颖
Owner 杭州易沃科信息科技有限公司
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