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Hemostatic dressing and preparation method thereof

A technology of hemostatic dressing and composite hydrogel, which can be used in pharmaceutical formulations, bandages, surgery, etc., and can solve the problems of large blood flow shock, large blood volume at the wound, and failure.

Active Publication Date: 2022-02-08
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For massive and rapid blood loss caused by severe tissue and organ damage, due to the large amount of blood at the wound site and the large impact of blood flow, the hemostatic material is easily soaked by blood quickly, resulting in poor adhesion performance and decreased hemostatic effect or even failure.

Method used

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  • Hemostatic dressing and preparation method thereof
  • Hemostatic dressing and preparation method thereof
  • Hemostatic dressing and preparation method thereof

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preparation example Construction

[0049] The application also provides a preparation method of a hemostatic dressing, comprising:

[0050] Step 100: dissolving the starch and the organic precursor in water and mixing them to obtain a precursor solution, allowing the organic precursor to react to obtain an ungelatinized starch-based composite hydrogel;

[0051] Step 200: subjecting the ungelatinized starch-based composite hydrogel to gelatinization treatment to obtain the starch-based composite hydrogel, and the temperature of the gelatinization treatment is 70° C. to 95° C.;

[0052] Step 300: Disperse the starch-based composite hydrogel in a diluent to obtain a hemostatic dressing.

[0053] In step 100 of the present application, the starch is ungelatinized water-soluble starch, and the starch includes one or more of tapioca starch, potato starch, sweet potato starch, glutinous rice starch, mung bean starch and corn starch. In some embodiments of the present application, starch is dissolved in water to obtain ...

Embodiment 1

[0065] A hemostatic dressing, comprising starch-based composite hydrogel and oleic acid, the starch-based composite hydrogel includes a fiber network structure formed by the reaction of composite macromolecular compounds and a network structure formed by gelatinization of tapioca starch, and the network structure is interspersed with Attached to the inside of the fiber network structure, wherein the composite polymer compound includes sodium alginate modified by hydroxysuccinimide ester, and the mass ratio of tapioca starch to the composite polymer compound is 1:0.1. The water content of the starch-based composite hydrogel is 20%.

[0066] The preparation of the above-mentioned hemostatic dressing of the present embodiment:

[0067] 1) Preparation of sodium alginate modified with hydroxysuccinimide ester

[0068] Dissolve 3 grams of sodium alginate in 100 ml of water, add 3 grams of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and 3 grams of N-hydroxysuccinyl ...

Embodiment 2

[0080]A hemostatic dressing, comprising starch-based composite hydrogel and oleic acid, the starch-based composite hydrogel includes a fiber network structure formed by the reaction of composite macromolecular compounds and a network structure formed by gelatinization of tapioca starch, and the network structure is interspersed with Attached to the inside of the fiber network structure, wherein the composite polymer compound includes sodium alginate and hydroxysuccinimide ester modified polyacrylic acid, and the mass ratio of tapioca starch to the composite polymer compound is 1:0.15. The water content of the starch-based composite hydrogel is 20%.

[0081] The preparation of the above-mentioned hemostatic dressing of the present embodiment:

[0082] 1) Preparation of hydroxysuccinimide ester modified acrylic acid

[0083] Dissolve 3 grams of acrylic acid in 100 milliliters of water, add 6 grams of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and 6 grams of N-...

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Abstract

The invention provides a hemostatic dressing which comprises starch-based composite hydrogel and a diluent, and the starch-based composite hydrogel comprises a fiber network structure and a network structure which is inserted and attached to the interior of the fiber network structure; the fiber network structure comprises a composite high-molecular compound, and the composite high-molecular compound comprises a hydroxyl succinimide ester modified group; the net-shaped structure comprises starch paste. The hemostatic dressing not only has excellent tissue adhesion capability and can resist blood flow impact so as to be stably attached to a wound part, but also has strong liquid absorption capability and swelling capability, and the volume of the hemostatic dressing can be expanded after absorbing body fluid so as to block a damaged blood vessel, so that rapid and simple hemostasis is realized. The invention further provides a preparation method of the hemostatic dressing.

Description

technical field [0001] The present application relates to the field of hemostatic materials, in particular to a hemostatic dressing and a preparation method thereof. Background technique [0002] Injury to the human body usually results in blood loss, and rapid and massive blood loss can pose a serious threat to a person's bodily functions and even life. Therefore, rapid hemostasis of wounds is crucial in emergency wound management and surgical procedures. For the massive and rapid blood loss caused by severe tissue and organ damage, due to the large amount of blood at the wound site and the large impact of blood flow, the hemostatic material is easily soaked by blood quickly, resulting in poor adhesion performance, decreased hemostatic effect or even failure. Therefore, it is necessary to provide a new hemostatic material that can be stably attached to the wound surface, and can quickly block damaged blood vessels, accelerate blood coagulation, and realize rapid hemostasis...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/06A61L24/00A61L24/08A61L24/10A61L26/00
CPCA61L24/08A61L24/06A61L24/046A61L24/104A61L24/102A61L24/0031A61L26/0023A61L26/0019A61L26/0014A61L26/0033A61L26/0038A61L26/008A61L2400/04
Inventor 杜学敏赵启龙胡豪
Owner SHENZHEN INST OF ADVANCED TECH
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