Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing

A technology of gallium ion and water injection, which is used in pharmaceutical formulations, medical science, bandages, etc., to achieve the effects of good tissue adhesion, good biocompatibility, and not easy to fall off

Pending Publication Date: 2022-03-18
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, gallium ions have not been used in the dev

Method used

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  • Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing
  • Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing
  • Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing

Examples

Experimental program
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Example Embodiment

[0039] Example 1:

[0040] This embodiment provides a method of preparing an injectable hydrogel dressing based on polyphenol-gallium ion coordination, the preparation method comprising the steps of:

[0041] (1) 480 mg of chitosan is dissolved in 8 ml deionized water to give an S1 solution;

[0042] (2) 200 mg tannic acid is dissolved in 2 ml deionized water to obtain S2 solution;

[0043] (3) 30 mg of gallium nitrate is dissolved in 300 μl of deionized water to obtain S3 solution;

[0044] (4) 8 ml S1 solution, 2 ml S2 solution and 300 μl S3 solution were mixed, and stirred at 25 ° C for 1 min to mix uniform, followed by regulating the pH of the mixed solution to 7.5 with a 0.1 mol / L sodium hydroxide solution, standing for 5 min The mixed solution is adequately gel, i.e., an injectable hydrogel dressing (chitosan / tannic acid / nitrate hydrogel dressing) based on polyphenol-gallium ion coordination.

Example Embodiment

[0045] Example 2:

[0046] This embodiment provides a method of preparing an injectable hydrogel dressing based on polyphenol-gallium ion coordination, the preparation method comprising the steps of:

[0047] (1) 500 mg of sulfonated chitosan (sulfonated chitin reference document BiomarelIals, 2009, 30, 1715-1724) is dissolved in 8 ml deionized water to give an S1 solution;

[0048] (2) 100 mg of anthocyanin is dissolved in 2 ml deionized water to give an S2 solution;

[0049] (3) 50 mg of nitrate is dissolved in 300 μl of deionized water to obtain S3 solution;

[0050] (4) 8 ml of S1 solution, 2 ml S2 solution and 300 μl S3 solution were mixed, and stirred at 25 ° C for 1 min to mix uniform, then adjusted the pH of the mixed solution to 7.5 with 0.1 mol / L sodium bicarbonate solution, stand for 5 min The mixed solution is adequately gel, i.e., an injectable hydrogel dressing (sulfonated chitosan / anthocyanitritis / nitrate hydrogel dressing) based on polyphenol-gallium ion coor...

Example Embodiment

[0051] Example 3:

[0052] This embodiment provides a method of preparing an injectable hydrogel dressing based on polyphenol-gallium ion coordination, the preparation method comprising the steps of:

[0053] (1) 600 mg of chitosan is dissolved in 9 ml of deionized water to give an S1 solution;

[0054] (2) The 75 mg table did not have a supper, and the supass (EGCG) was dissolved in 1.5 ml of deionized water to give an S2 solution;

[0055] (3) 60 mg of gallium chloride was dissolved in 300 μL of deionized water to give an S3 solution;

[0056] (4) 9 ml of S1 solution, 1.5 ml S2 solution and 300 μl of S3 solution were mixed, stirred at 25 ° C for 1 min to mix uniform, then adjusted the pH of the mixed solution to 8.0 with 0.1 mol / L sodium carbonate solution. The MIN is adequately gelled, i.e., an injectable hydrogel dressing (chitosan / EGCG / chloride hydrogel dressing) based on polyphenol-gallium ion coordination.

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Abstract

The invention particularly relates to an injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as a preparation method and application of the injectable hydrogel dressing. The hydrogel compound dressing is prepared from the following raw materials in percentage by mass: 3-30% of an antibacterial high-molecular compound, 3-30% of a natural polyphenol compound, 3-30% of an inorganic gallium compound and deionized water. The hydrogel auxiliary material has good injectable performance, antibacterial performance, hemostatic performance and antioxidant effect, and can significantly improve the wound healing effect in a mouse full-thickness skin wound simulation model.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an injectable hydrogel dressing based on polyphenol-gallium ion coordination and its preparation method and application. Background technique [0002] When the skin is traumatized, it will be infected by various bacteria, which can cause complications and even death in severe cases. Therefore, it is very important to treat wounds, accelerate wound healing, and prevent various bacterial infections. Using dressings to treat wounds can effectively prevent the above problems from happening. A good dressing needs to have the advantages of low price, convenient use, excellent air permeability, strong moisture retention, and good heat retention, and has the functions of debridement, absorption of exudate, and prevention of secondary infection. [0003] Hydrogel is a kind of polymer with hydrophilicity and three-dimensional network structure, which is favored by the...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L5/08C08L5/02C08K5/134C08K5/13C08K3/28C08K3/16C08K3/30C08K5/098
CPCC08J3/075C08J3/24A61L26/008A61L26/0004A61L26/0023A61L26/0066C08J2305/08C08J2305/02C08K5/134C08K5/13C08K3/28C08K3/16C08K2003/3045C08K5/098A61L2400/06A61L2300/404A61L2300/418A61L2300/236A61L2300/102C08L5/08C08L5/02
Inventor 黄达王明达翁祖铨杜佳豪
Owner FUZHOU UNIVERSITY
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