Anti-adhesion fiber membrane with hemostasis and antibiosis functions and preparation method thereof

Abstract

The invention discloses an anti-adhesion fiber membrane with hemostasis and antibiosis functions and a preparation method thereof. The preparation method comprises the following steps of: dissolving medicinal molecules into an organic or inorganic solvent to prepare a medicinal molecular solution; dissolving different high molecular materials into medicinal solutions of a hemostasis agent and an antibiosis agent respectively to prepare a high molecular solution; and performing electrostatic spinning on a mixed solution of organic high molecules and the hemostasis agent and a mixed solution of high molecules and the antibiosis agent to obtain a compound fiber material. In the invention, nanofiber is produced by using an electrostatic spinning technology; an organic high molecular solution and the medicinal molecules are mixed for electrostatic spinning to obtain the compound fiber material; by adjusting the high molecular material, the embedding amount and embedding rate of medicaments are increased, a fiber material which can keep the medicinal bioactivity and is used for controlling the release of different medicaments at different stages is prepared, and dual effects of preventing postoperative adhesion and postoperative infection can be achieved; and moreover, the entire preparation process is simple, has low cost, and has wide application prospect in the field of surgical operation.

Description

Technical field: [0001] The invention relates to an anti-adhesion fibrous membrane and a preparation method thereof, in particular to an anti-adhesion fibrous membrane with hemostatic and antibacterial functions and a preparation method thereof. Background technique: [0002] Postoperative adhesion and local inflammation are one of the unsolved important medical problems in the field of surgery at home and abroad. Adhesion can not only cause serious complications, but also bad adhesion is one of the main reasons for the significant increase in complications during reoperation. For a long time, the medical community has done a lot of work on the prevention of postoperative adhesion, but the effect is not obvious. With the rapid development of absorbable medical materials, the use of special biomaterials as spacers has become an effective way to prevent postoperative adhesions. [0003] The ideal anti-adhesion material should have good biocompatibility, suitable tissue adhes...

AI Technical Summary

Problems solved by technology

For a long time, the medical community has done a lot of research on the prevention of postoperative adhesions, but the curative effect is not obvious