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Medicine-loading sustained-release micro-capsule and preparing method thereof

A slow-release microcapsule and drug-carrying technology, which is used in pharmaceutical formulations, drug delivery, and non-active ingredients medical preparations, etc. Biocompatibility, good physical and chemical properties, smooth drug release effect

Inactive Publication Date: 2009-12-23
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sustained release period is short, so that the effective action time of the drug is short and cannot meet the needs

Method used

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  • Medicine-loading sustained-release micro-capsule and preparing method thereof
  • Medicine-loading sustained-release micro-capsule and preparing method thereof
  • Medicine-loading sustained-release micro-capsule and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: 0.2g drug gentamicin sulfate is dissolved in 2ml mass fraction and is 6% hydrochloric acid, and adds 0.04g water-soluble surfactant polyoxyethylene sorbitan monooleate, mixes uniformly to form drug- Aqueous solution A of surfactant-precipitating agent, wherein the drug concentration is about 100mg / ml, and the concentration of water-soluble surfactant is about 0.02g / ml; add 2.0g of oil-soluble surfactant sorbitan monooleate to 50ml In the water-insoluble non-polar oil solvent cyclohexane, mix uniformly to form a surfactant-oil solvent solution B, wherein the concentration of the oil-soluble surfactant is about 0.04g / ml; under stirring conditions, the solution A Slowly add in solution B, the volume ratio of solution A and solution B is 1:25, keep stirring until a stable water / oil type emulsion C is formed; 25% of the mass), and continued to stir for 24 hours, so that the silicon source material was fully hydrolyzed and polycondensed, and a silica coating lay...

Embodiment 2

[0036] Embodiment 2: Add 0.4g drug gentamycin sulfate and 0.04g water-soluble surfactant polyoxyethylene sorbitan monooleate to 2ml mass fraction of 6% hydrochloric acid, mix uniformly to form drug-surfactant Aqueous solution A of agent-precipitating agent, wherein drug concentration is about 200mg / ml, and water-soluble surfactant concentration is about 0.02g / ml; In 50ml of water-insoluble non-polar oil solvent cyclohexane, mix uniformly to form surfactant-oil solvent solution B, wherein the concentration of oil-soluble surfactant is about 0.04g / ml; under stirring conditions, the solution A is slowly added to solution B, the volume ratio of solution A to solution B is 1:25, and the stirring is continued until a stable water / oil emulsion C is formed; 2ml of tetraethyl orthosilicate, a silicon source material, is added to emulsion C (according to aqueous solution 25% of the mass of A), and continued to stir for 30 hours, so that the silicon source material was fully hydrolyzed a...

Embodiment 3

[0037] Embodiment 3: 0.2g drug salbutamol sulfate is dissolved in 2ml mass fraction and be in the hydrochloric acid of 6%, and add 0.04g water-soluble surfactant polyoxyethylene sorbitan monooleate, mix uniformly to form drug-surfactant Aqueous solution A of agent-precipitating agent, wherein drug concentration is about 100mg / ml, water-soluble surfactant concentration is about 0.02g / ml; 2.0g oil-soluble surfactant sorbitan monooleate is added into 50ml insoluble In the non-polar oil solvent cyclohexane of water, mix evenly to form a surfactant-oil solvent solution B, in which the concentration of oil-soluble surfactant is about 0.04g / ml; under stirring conditions, slowly add solution A In solution B, the volume ratio of solution A to solution B is 1:25, and the stirring is continued until a stable water / oil emulsion C is formed; 25% meter), and continue to stir for 24 hours, so that the silicon source material is fully hydrolyzed and polycondensed, and a silica coating layer i...

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Abstract

The invention relates to a novel drug-loaded sustained-release microcapsule and a preparation method thereof. It involves material preparation and medical application fields, and is expected to be used in food, spices, cosmetics, pesticides, biology and other fields. A drug / silicon dioxide new microcapsule system with a core-shell composite structure is prepared by emulsion in-situ coating and synthesis, which can embed drugs of different molecular sizes in the hollow interior, making it truly a warehouse for drug storage. Increase the drug load, and use the shell structure to adjust the drug release rate to achieve the purpose of sustained release.

Description

Technical field: [0001] The invention relates to a drug-loaded sustained-release microcapsule and a preparation method thereof. It involves material preparation and medical application fields, and is expected to be used in food, spices, cosmetics, pesticides, biology and other fields. Background technique: [0002] In recent years, drug sustained-release technology has attracted widespread attention due to its advantages of prolonging the release time of drugs, improving drug efficacy, reducing the number of medications and drug side effects, and preventing drug degradation. [0003] At present, the most widely used in the preparation of sustained-release drugs is microcapsule technology, that is, the capsule material is used to coat the drug and the capsule core material to form a microcapsule, and the drug must pass through the capsule wall to achieve sustained release. Effect. However, the preparation process of traditional microcapsules is complicated, and there are ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K47/02A61K47/34A61K45/00A61K47/26
Inventor 陈建峰王志辉文利雄王洁欣
Owner BEIJING UNIV OF CHEM TECH
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