73 results about "Drug degradation" patented technology

An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0.05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.

The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising diazepam to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. In each of these instances, antioxidants are utilized to prolong product integrity.

The invention relates to synchronous drug delivery composition comprising a polymeric matrix which comprises hydrogel blended with a hydrophobic polymer, so as to form an erodible matrix, a drug, and, optionally, an agent which enhances intestinal drug absorption and/or an agent which inhibits intestinal drug degradation,

wherein erosion of the erodible matrix, permits synchronous release of the drug, the hydrogel and the intestinal drug absorption agent and/or the agent which inhibits intestinal drug degradation.

The invention belongs to the field of biological medicine, and particularly relates to a nucleic acid lipid nano particle composition, a pharmaceutical preparation containing the same, and a preparation method and application thereof. The nucleic acid lipid nano particle composition comprises drug-loaded lipid nano particles and auxiliary materials, the mass ratio of the drug-loaded lipid nano particles to the auxiliary materials is (0.1-10): (90-99.9), the drug-loaded lipid nano particles comprise nucleic acid drugs and lipid carriers, the mass ratio of the nucleic acid drugs to the lipid carriers is 1: (2-30), the composition is good in stability, the nucleic acid drugs are not degraded due to too high temperature, the composition can be stored and transported at normal temperature, can be administered in various ways, and are quick in effect taking and high in bio-availability, large-scale production can be realized, the yield is high, and the repeatability is good.

The invention relates to a topiramate sustained release preparation pharmaceutical composition and a preparation method thereof. The topiramate sustained release preparation pharmaceutical composition is prepared from sustained release particles and preparation auxiliary materials; and the sustained release particles consist of 35%-45% of topiramate, 40%-50% of filler, 2.5%-6% of adhesives, 2%-10% of stabilizer, 5.0%-6.5% of sustained release coating materials, 2.0%-3.0% of porogen materials and 1%-2% of plasticizer. By the stabilizer, stability of the preparation can be improved obviously, and degradation of medicines is reduced. After a patient orally takes the topiramate sustained release preparation, stable and effective blood concentration can be maintained, occurrence rate of side reaction is reduced, and epilepsy is controlled well. In addition, the patient orally takes the preparation once every day, and compliance of the patient is greatly improved. Granulation is implemented at one step by a fluidized bed, special technologies are not required, and industrial production is facilitated.

The invention belongs to the field of medicinal preparations, and relates to a solid preparation and a preparation method thereof, in particular to a solid preparation of clopidogrel or pharmaceutically acceptable salt of the clopidogrel as well as a preparation method thereof. The solid preparation is mainly prepared by mixing the clopidogrel or the pharmaceutically acceptable salt thereof with dimeticone and then processing the obtained mixture according to a conventional solid preparation processing method. By adopting the dimeticone, the invention has the advantages of preventing a dextroisomer of the clopidogrel from converting into a levoisomer, preventing the clopidogrel from being degraded into clopidogrel acid, being applicable to the formula and process for large-scale production of the preparation, solving the problem of drug degradation, improving drug stability, solving sticking and picking phenomena during the tabletting process, and improving product quality.

The invention discloses a sewage m .ing treatment device, and belongs to the technical filed of sewage treatment. The sewage mixing treatment device comprises a mixing box, a centrifugal stirring device, a pneumatic mixing device, an inner wall stirring device, a drug adding device, a sewage inlet pipe and a sewage outlet pipe; and the centrifugal stirring device is arranged in the mixing box, thepneumatic mixing device is arranged on the bottom wall of the mixing box, the inner wall stirring device is arranged on the inner wall of the mixing box, the drug adding device and the sewage inlet pipe are arranged at the top of the mixing box, and the sewage outlet pipe is arranged at the bottom of the side wall of the mixing box. According to the sewage mixing treatment device, sewage and a drug additive are stirred and mixed through centrifugal stirring, drug sedimentation and adhesion are avoided through the airflow impact and inner wall cleaning and brushing effects, by adding air and increasing the temperature, the efficiency of degrading impurities through the drug is improved, the sewage and the drug are fully mixed by adopting multiple procedures and devices for increasing the mixing degree of the sewage and the drug in the mode of drug administration at time intervals, and then the sewage purifying effect is improved.

The invention relates to a nanometer lipid emulsion which comprises a drug, oil, an emulgator and water, wherein the solubility of the drug is 0-0.0005g/ml and the drug is difficult to dissolve in water. The emulsion is clear and is capable of reducing the drug degradation and the emulsion droplet agglutination caused by ultrahigh pressure and high temperature. The drug is capable of being stably packed in the emulsion droplet, so that the toxic or side effect of the drug is reduced.

The invention discloses an iodine drug degradation method based on an MOF template method, and particularly relates to a method for preparing a copper-iron composite oxide to activate sulfite to generate sulfate free radicals to degrade iodine drugs in water on the basis of the MOF template method. According to the method, an MOF material can serve as a self-sacrificial template, the copper-iron composite oxide is prepared after calcination, the characteristics of high specific surface area and high catalytic activity of the copper-iron composite oxide are used for activating the sulfite to generate the sulfate free radicals to degrade the iodine drugs. The copper-iron composite oxide prepared on the basis of the MOF template method is easy to recycle, and still has a good activation effect after being recycled multiple times. The method is suitable for degradation of various iodine drugs, is high in activation efficiency and simple and feasible to operate, can efficiently activate the sulfite to degrade the iodine drugs under neutral conditions, and is relatively good in advantage.

The invention relates to an enteric-coated pellet containing a respiratory syncytial virus inhibitor. The enteric-coated pellet comprises a blank pellet core, a first isolated layer, a drug carrying layer, a second isolated layer and an enteric coating layer from inside to outside. The weight gain of the first isolated layer is 2-10%, the weight gain of the drug carrying layer is 10-200%, the weight gain of the second isolated layer is 2-10% and the weight gain of the enteric coating layer is 5-50%. The first isolated layer and the second isolated layer comprise Opadry. The drug carrying layer comprises a respiratory syncytial virus inhibitor and a binder. The enteric coating layer comprises an enteric-soluble material, a plasticizer, an antiadherent and an emulsifier. The enteric-coated pellet prevents drug degradation in the gastric juice and irritation on the stomach, optimizes pharmacokinetic parameters, greatly improves a drug safety window and anti-RSV activity, can be prepared through simple processes and is suitable for large-scale production and application.

The invention discloses mesoporous silicon nanoparticles capable of responding to X-rays to release drugs as well as a preparation method and application of the mesoporous silicon nanoparticles, and belongs to the technical field of drug carriers. The preparation method of the mesoporous silicon nanoparticles capable of responding to X-rays to release drugs comprises the following steps: (1) preparing bis[3-(triethoxysilyl)propyl]diselenide; and (2) preparing double-selenium mesoporous silicon nanoparticles capable of responding to X-rays to release drugs. The prepared double-selenium mesoporous silicon is the first mesoporous silicon capable of responding to X-rays to generate skeleton degradation. Bis[3-(triethoxysilyl)propyl]diselenide and tetraethoxysilane are used as a mixed silicon source, the mesoporous silicon containing double-selenium bonds is synthesized by a copolycondensation method, and the prepared double-selenium mesoporous silicon can not only respond to X-rays to rapidly degradate and release drugs, but also respond to tumor redox microenvironments to slowly release drugs so as to regulate the drug degradation speed and the drug release speed.

The invention relates to the field of medicinal accessories, and specifically provides a drug carrier, a drug preparation and a preparation method. The drug carrier provided by the invention is prepared from two polypeptides or one of the pharmaceutically acceptable derivatives of the two polypeptides or combination of at least two of the pharmaceutically acceptable derivatives. The drug carrier can from a stable drug complex with a polar drug. On the premise of not influencing the drug effect, the drug carrier greatly reduces the drug degradation speed, thus prolongs the in-vivo half-life period of the drug in a human body, and realizes a slow release function of the drug. Meanwhile, the drug carrier also can improve the drug solubility and is favorable for enhancing the absorption and effect of the drug, thereby lowering the medical cost. The drug preparation provided by the invention comprises the polar drug and the drug carrier, and has the advantages of high safety, long in-vivo half-life period and high solubility. The preparation method of the drug preparation provided by the invention is simple and easy to operate, imposes no special requirements on the equipment, and doesnot increase the production cost.

The invention relates to a composition for preventing scar adhesion, a postoperative anti-adhesion material and application. Epidural scar adhesion is an important cause of postoperative lumbar surgery failure syndrome, and the invention aims to provide a drug-loaded postoperative sealing material which can seal wounds and realize stable release of drugs at the same time. The invention firstly provides the mitomycin C-IFN gamma-sodium hyaluronate conjugate for preventing scar adhesion, the conjugate can effectively inhibit scar tissue formation and slow down the drug degradation speed, and when the conjugate is applied to a polyethylene glycol sealant, the sealing effects of low swelling and rapid condensation can be achieved. The product is especially suitable for spinal surgeries such as laminectomy and the like, and has good clinical application value.

The invention discloses a fentrazamide-containing weeding microemulsion. The microemulsion comprises effective active ingredients, a surfactant, an emulsifier, namely, dioctylsulfosuccinate sodium salt, a cosolvent, namely, ethyl alcohol, water, an anti-freezing agent, namely, glycerin, and a synergist, namely, piperonyl butoxide, wherein the effective active ingredients comprise azimsulfuron, the fentrazamide and imazaquin; the surfactant is octaphenyl polyoxyethyiene sulfonate. The microemulsion has the very good eliminating effect on field weeds and is safe and efficient, the drug degradation effect is good, and few residues exist.

The invention belongs to the technical field of medicines and relates to a salmon calcitonin-phospholipid complex and its lipid nanoparticle and preparation method. The salmon calcitonin-phospholipid complex and its lipid nanoparticle can improve drug lipid solubility, have a certain intestinal adhesion, can be easily absorbed through intestinal mucosa and can prevent drug degradation caused by gastrointestinal tract protease. The lipid nanoparticle of the salmon calcitonin-phospholipid complex comprises the salmon calcitonin-phospholipid complex, a lipid material, a surfactant and water and is prepared through a film dispersion method. The water-soluble drug nanoparticle obtained through the preparation method has a high drug oil-liquid distribution coefficient and good membrane permeability and improves oral bioavailability. The preparation method has simple processes.

The invention provides a new Lenvatinib medicine composition and a preparation method thereof. The medicine composition contains Lenvatinib or pharmaceutically acceptable salt of the Lenvatinib and ananti-acid anti-bile gastric mucosa protective agent, wherein the protective agent is hydrotalcite. The medicine composition can fully guarantee that a product is dissolved out, medicine degradation is avoided, and the quality of the product is more favorably guaranteed.