Drug carrier, drug preparation and preparation method
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A technology for pharmaceutical preparations and drugs, applied in the field of pharmaceutical excipients, can solve the problems of poor stability and solubility of biological drugs, need to be further improved, loss of water solubility of drugs, etc., and achieves a preparation method that is simple and easy to operate, uniform in composition, and good in stability. Effect
Active Publication Date: 2018-06-22
王琦
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Problems solved by technology
[0004] The first purpose of the present invention is to provide a drug carrier to alleviate the problems of the reduction or loss of drug activity caused by the modification of the drug carrier in the prior art and the further improvement of the water solubility of the drug
[0005] The second object of the present invention is to provide a pharmaceutical preparation to alleviate the problems of poor stability and solubility of biopharmaceuticals in the prior art
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preparation example Construction
[0059] The present invention further provides a preparation method of the above-mentioned pharmaceutical preparation, which includes the following steps: mixing the drug carrier and the polar drug in the buffer solution at 0-5° C. to obtain the pharmaceutical preparation.
[0060] The preparation method is simple and easy to operate, has no special requirements for equipment, and does not increase production costs. The temperature is typically but not limited to 0°C, 1°C, 2°C, 3°C, 4°C or 5°C.
[0061] In a preferred embodiment of the present invention, a polar drug is added to the drug carrier solution to obtain a drug preparation.
[0062] In a preferred embodiment of the present invention, the solvent of the drug carrier solution is phosphoric acid solution with a pH value of 3-7. The pH of the phosphoric acid solution is typically, but not limited to, 3, 4, 5, 6 or 7.
[0063] In a preferred embodiment of the present invention, the polar drug is added to the drug carrier...
Embodiment 1
[0072] This embodiment provides a drug carrier, and the sequence of the polypeptide is shown in SEQ ID NO 1.
Embodiment 2
[0074] This embodiment provides a drug carrier, and the sequence of the polypeptide is shown in SEQ ID NO 2.
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Abstract
The invention relates to the field of medicinal accessories, and specifically provides a drug carrier, a drug preparation and a preparation method. The drug carrier provided by the invention is prepared from two polypeptides or one of the pharmaceutically acceptable derivatives of the two polypeptides or combination of at least two of the pharmaceutically acceptable derivatives. The drug carrier can from a stable drug complex with a polar drug. On the premise of not influencing the drug effect, the drug carrier greatly reduces the drug degradation speed, thus prolongs the in-vivo half-life period of the drug in a human body, and realizes a slow release function of the drug. Meanwhile, the drug carrier also can improve the drug solubility and is favorable for enhancing the absorption and effect of the drug, thereby lowering the medical cost. The drug preparation provided by the invention comprises the polar drug and the drug carrier, and has the advantages of high safety, long in-vivo half-life period and high solubility. The preparation method of the drug preparation provided by the invention is simple and easy to operate, imposes no special requirements on the equipment, and doesnot increase the production cost.
Description
technical field [0001] The invention relates to the field of pharmaceutical excipients, in particular to a pharmaceutical carrier, a pharmaceutical preparation and a preparation method. Background technique [0002] Biopharmaceuticals refer to the use of the research results of biology, medicine, biochemistry, etc., and the comprehensive utilization of principles and methods of physics, chemistry, biochemistry, biotechnology, and pharmacy, and the use of organisms, biological tissues, cells, body fluids, etc. to manufacture A class of products used for prevention, treatment and diagnosis. Biological drugs include nucleic acid, protein, carbohydrate, lipid and amino acid drugs. At present, the research of biopharmaceuticals as drugs has achieved rapid development, which has the advantages of strong therapeutic pertinence, high pharmacological activity, small toxic and side effects and high nutritional value. But at the same time, there are many problems in the delivery syst...
Claims
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Application Information
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