60results about How to "Improve safety and efficacy" patented technology

Smart sensors are employed to determine one or more of drug identification, dose, flow rate, concentration, agglomeration, and degradation and / or other characteristics of drug administration that can be detected via sensing technology. A smart sensor(s) can be coupled to or retrofitted onto injection pen injectors and / or drug delivery cartridges and / or infusion sets or cannulae, enabling infusion sets, pen injector systems or drug delivery cartridges to improve tracking of drug self-administration and stop medication errors that occur primarily through self or automated injection (e.g., due to incorrect or incomplete dosing, excessive dose or rate, incorrect drug, or drug degradation).

A medical tool includes a flexible sleeve placed over a flexible endoscope tube of an endoscope, with the flexible sleeve having one or more channels for providing additional access to the interior of a patient's body. Various tools may be inserted into the channels in order to perform surgical techniques within the body, such as within the gastrointestinal (GI) tract of the patient. Such insertable tools may include scalpels, scissors, or gripping tools. The tools may be flexible tools, and may include electrically-powered tools or non-electrically-powered tools.

A convenience kit which provides a basic configuration for use in measuring, filling and dispensing medication and flush solutions to IV sets and patient catheters through needleless connectors while improving safety and efficacy by requiring fewer post-sterilization makes and breaks compared to conventional filling and dispensing methods. Further, the kit improves flush compliance by facilitating dispensing of flush solutions and decreases likelihood of infections by providing for flushing of patient lines and catheter connecting fittings without line breaks. Convenience of operation is provided by a two-syringe assembly which is operable by a single hand for selective dispensing accomplished from either of the two syringes while obstructing flow from the other syringe. The kit comprises a clip for stabilizing the two syringe assembly.

The invention relates to a device system and method for providing images of an in vivo site during in vivo procedures, such as laparoscopy wherein the device is capable of illuminating an internal body cavity and has an immobilization unit to fasten the device to a desired location in vivo.

IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM.

Two convenience kits are disclosed. A first convenience kit provides a basic configuration for use in measuring, filling and dispensing medication and flush solutions to IV sets and patient catheters through needleless connectors while improving safety and efficacy by requiring fewer post-sterilization makes and breaks compared to conventional filling and dispensing methods. A second convenience kit which, being a companion to the first convenience kit, provides safety in access to a vial. Methods of use of both kits improve flush compliance by facilitating dispensing of flush solutions and decreases likelihood of infections by providing for flushing of connecting sites while reducing numbers of breaks required for associated medical procedures.

An apparatus for treating a subcutaneous fat region is provided. The apparatus includes a housing that has a skin contacting portion defining a chamber. The apparatus also includes a first spaced region in the housing through which a coolant passes and a second spaced region in the housing that is at least partially evacuated of air. The apparatus further includes a source of electromagnetic radiation, a source of vacuum in fluid communication with the chamber, and a source for the coolant.

IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM.

An apparatus method for establishing a Transjugular Intrahepatic Portosystemic Shunt between the portal vein from a hepatic vein. The apparatus comprises an elongated hollow outer guide; an outer handle having an inner lumen and a first luer lock, the outer handle attached at a proximal end of the outer guide, the outer guide in flow communication with the inner lumen and the first luer lock; an elongated hollow inner needle; and a hub having a second luer lock, the hub attached at a proximal end of the inner needle, the inner needle in flow communication with the second luer lock. The inner needle is slidingly received into the outer guide through the inner lumen. The inner needle rotates within the outer guide by manipulation of the hub; and a distal tip of the inner needle is deployed out of and beyond a distal tip of the outer guide.

The invention relates to a method for refining a ceftriaxone sodium crude product. The method comprises the following steps of: adding the ceftriaxone sodium crude product and sodium metabisulfite into a mixed solvent of water for injection and methanol, and dissolving until the solution is clarified; sterilizing the solution, filtering, and adding a leaching agent; adding ceftriaxone sodium seed crystals, and cultivating crystals after the crystals are precipitated; and continuing to add the leaching agent, precipitating the crystals completely, washing the crystals and drying to obtain a ceftriaxone sodium refined product. In the method, the mixed solvent is used as an initial solvent of the ceftriaxone sodium to improve the stability of the ceftriaxone sodium in a single hydrosolvent system; and in the presence of the sodium metabisulfite, the product is low in total impurities, less in degradation and stable in colors, the color of the ceftriaxone sodium refined product is No.1 lighter than that of crystals in the single hydrosolvent system, and the purity and quality of the product are improved.

The invention provides an ultrahigh voltage transformer substation main equipment porcelain bushing shock resistance detection method and component. The method comprises the steps that earthquake time-process waves used for detection are determined; and a tested porcelain bushing is detected according to the detection condition and the detection target, and the detection environment of the tested porcelain bushing is adjusted and shock resistance of the tested porcelain bushing is judged. The component comprises a displacement sensor, acceleration sensors, strain gauges and a bracket which is arranged on an earthquake test table. According to the method and the component, a set of shock resistance assessment system aiming at the ultrahigh voltage transformer substation main equipment porcelain bushing is clearly and completely constructed, and the pre-test, test and post-test operation process of the tested porcelain bushing is meticulously and efficiently detected so that shock resistance assessment capacity of the ultrahigh voltage porcelain bushing can be effectively and reliably enhanced, and safety and effectiveness of the porcelain bushing in the actual engineering application can be enhanced. The method and the component are elaborate and rigorous in structure and high in operability and have extremely high popularization condition.

The invention discloses a two-dimensional code generation method and device and a two-dimensional code recognition method and device. The two-dimensional code generation method comprises the steps that a first server sends a request for generating a two-dimensional code to a second server, wherein the request comprises information used for generating a two-dimensional code, and the second server performs digital signing on the information used for generating a two-dimensional code according to the received request for generating a two-dimensional code; two-dimensional code information containing a digital signature is sent to the first server; and the first server generates a two-dimensional code by using the two-dimensional code information. According to the embodiment of the invention, a two-dimensional code is generated through a cooperative effect between one server and another server, the safety and the effectiveness of the two-dimensional code are enhanced, and whether the two-dimensional code is tampered or not is facilitated to be recognized in the two-dimensional code recognition process.

The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.

The invention provides an upper-limb rehabilitation device of half-exoskeleton, including a base, a control system, a dynamical system, an input / output device, and a first movement combination or a second movement combination; the base is used to place the dynamical system and support the control system, the input / output device and the first or the second movement combination; the control system is used to manage the training data collected by the rehabilitation device; the dynamical system is used to provide driving force for the first or the second movement combination; the input / output device is used to input the training instruction of users and display the generated data during training; the first or the second movement combination is used to complete the upper-limb movement cooperating with users. The upper-limb rehabilitation device of half-exoskeleton can avoid the deviation of the motion trail and the pose between the moving body of the rehabilitation device and human body (the upper limb), prevent patients from suffering a secondary damage during their rehabilitation training, and improve the security and validity of rehabilitation movements.

An intubation device having a main body portion defining a first longitudinal axis, a distal tip portion coupled to the main body portion and defining a second longitudinal axis, and a deflection system having a single drive member extending within at least the distal tip portion and coupled thereto. The deflection system is operable to exert a tensile force upon the distal tip portion to articulate the distal tip portion relative to the main body portion between a resting position and a positive incline position and a negative incline position.

IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM.

The present invention relates, generally, to methods and compositions for allogeneic transplantation. More particularly, the invention relates to the use of alloreactive natural killer cells in order to enhance the efficacy and / or safety of allogeneic grafts in human subjects. The invention allows to increase the engraftment of an allogeneic grafts, even in myelo-reductive conditioning, to protect against GVHD and / or to eradicate malignant cells. The invention is particularly suited in allogeneic hematopoietic transplantations, particularly bone marrow transplantations.

The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.

An apparatus for treating a subcutaneous fat region is provided. The apparatus includes a housing that has a skin contacting portion defining a chamber. The apparatus also includes a first spaced region in the housing through which a coolant passes and a second spaced region in the housing that is at least partially evacuated of air. The apparatus further includes a source of electromagnetic radiation, a source of vacuum in fluid communication with the chamber, and a source for the coolant.

The present invention relates to a method for preparing accessory cells, said accessory cells may themselves be used for preparing activated NK cells that may be used in various therapeutic protocols (e.g. cancer treatment). More particularly, the present invention relates to a method for preparing an accessory cell comprising the steps consisting of i) providing a cell and ii) inhibiting in said cell the expression of a gene encoding for a Killer-Cell Immunoglobulin-like Receptor(s) (KIR) ligand.

The embodiment of the invention discloses an identity verification method, device and equipment. According to the scheme, the method comprises the steps that identity verification information shown bya user is acquired, the identity verification information is generated according to information fed back by a third-party server in response to an identity identifier generation request carrying a user identity certificate, and identity recognition information of the user is acquired; and performing identity verification on the user according to the identity verification information and the identity recognition information to obtain a verification result.

A convenience kit which provides a basic configuration for use in measuring, filling and dispensing medication and flush solutions to IV sets and patient catheters through needleless connectors while improving safety and efficacy by requiring fewer post-sterilization makes and breaks compared to conventional filling and dispensing methods. Further, the kit improves flush compliance by facilitating dispensing of flush solutions and decreases likelihood of infections by providing for flushing of patient lines and catheter connecting fittings without line breaks. Convenience of operation is provided by a two-syringe assembly which is operable by a single hand for selective dispensing accomplished from either of the two syringes while obstructing flow from the other syringe. The kit comprises a clip for stabilizing the two syringe assembly.

An apparatus method for establishing a Transjugular Intrahepatic Portosystemic Shunt (“TIPS”) between the portal vein from a hepatic vein. The apparatus comprises a multi-needle TIPS device designed to facilitate safer and more rapid catheterization of the portal vein. The method utilizes the multi-needle TIPS device to access the portal vein from the hepatic vein approach. The multi-needle TIPS device and method provides numerous benefits over previous TIPS devices and procedures and results in shorter and safer procedures. Use of multiple needles increases the probability of finding the portal vein more quickly.

The disclosure relates generally to alpha polyglutamated aminopterin, formulations containing liposomes filled with alpha polyglutamated aminopterin, methods of making the alpha polyglutamated aminopterin and liposome containing formulations, and methods of using polyglutamated alpha polyglutamated aminopterin and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).

The invention relates to a carbidopa-levodopa controlled release tablet and a preparation method of the tablet. The total dose of the carbidopa-levodopa controlled release tablet in the prior art reaches 250mg, but the total weight of the tablet is very small, so that a certain degree of difficulty is brought to the production process and the industrial production is constrained. The carbidopa-levodopa controlled release tablet disclosed by the invention comprises the following substances in percentage by mass: 15-17% of carbidopa, 60-70% of levodopa, 1-5% of a controlled release material, 0-3% of an adhesive, 5-15% of a filler, 0-2% of a lubricant and 1-4% of a film-forming material. According to the invention, the technical problem caused by large dose and small weight of tablets is thoroughly solved through a one-step granulation and coating technique; a medicine release curve similar to that of imported medicines is acquired; and the industrial production is facilitated.

The invention relates to recombinant oncolytic viruses that target tumor stem cells and various uses of these recombinant viruses. In particular, an oncolytic virus comprising a recombinant binding domain specific for a tumor stem cell marker is disclosed. Furthermore, the use of such oncolytic viruses for the treatment of cancer is disclosed.