Carbidopa-levodopa controlled release tablet and preparation method of tablet

A slow-release tablet and levodopa technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of small total weight of tablets, restrictions on industrial production, and production processes Problems such as development difficulty, to achieve the effect of easy industrial production, improve safety and effectiveness

Inactive Publication Date: 2013-07-10
浙江美华鼎昌医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Carbidopa controlled-release tablet is a drug developed and marketed by Merck Pharmaceuticals Co., Ltd., and its trade name is Xining. Its specification contains 50 mg of carbidopa and 200 mg of levodopa, and the total dose reaches 250 mg. However, the total weight of the tablet However, it is relatively small, which brings certain difficulties to the development of production technology and restricts industrial production.

Method used

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  • Carbidopa-levodopa controlled release tablet and preparation method of tablet
  • Carbidopa-levodopa controlled release tablet and preparation method of tablet
  • Carbidopa-levodopa controlled release tablet and preparation method of tablet

Examples

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Embodiment 1

[0024] Prescription composition (dosage per 1000 tablets, unit: g)

[0025]

[0026]

[0027] Weigh hydroxypropyl methylcellulose E15 and Opadry according to the prescription amount, add 95% ethanol and water to dissolve and use it as a coating solution for later use; carbidopa, levodopa, microcrystalline cellulose, hydroxypropyl Mix methylcellulose K15M and micropowder silica gel evenly, add the above-mentioned coating solution for fluidized bed granulation, dry, add additional magnesium stearate, mix evenly, and press into tablets with a conventional tablet machine.

Embodiment 2

[0029] Prescription composition (dosage per 1000 tablets, unit: g)

[0030]

[0031] Weigh hydroxypropyl methylcellulose E15 and Opadry according to the prescription amount, add 95% ethanol and water to dissolve and use it as a coating solution for later use; carbidopa, levodopa, microcrystalline cellulose, hydroxypropyl Mix methylcellulose K4M and micropowder silica gel evenly, add the above-mentioned coating solution for fluidized bed granulation, dry, add additional magnesium stearate, mix evenly, and press into tablets with a conventional tablet machine.

Embodiment 3

[0033] Prescription composition (dosage per 1000 tablets, unit: g)

[0034]

[0035]

[0036] Weigh hydroxypropyl methylcellulose E15 and Opadry according to the prescription amount, add 95% ethanol and water to dissolve and use it as a coating solution for later use; carbidopa, levodopa, microcrystalline cellulose, hydroxypropyl Mix methylcellulose K15M and micropowder silica gel evenly, add the above-mentioned coating solution for fluidized bed granulation, dry, add additional magnesium stearate, mix evenly, and press into tablets with a conventional tablet machine.

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Abstract

The invention relates to a carbidopa-levodopa controlled release tablet and a preparation method of the tablet. The total dose of the carbidopa-levodopa controlled release tablet in the prior art reaches 250mg, but the total weight of the tablet is very small, so that a certain degree of difficulty is brought to the production process and the industrial production is constrained. The carbidopa-levodopa controlled release tablet disclosed by the invention comprises the following substances in percentage by mass: 15-17% of carbidopa, 60-70% of levodopa, 1-5% of a controlled release material, 0-3% of an adhesive, 5-15% of a filler, 0-2% of a lubricant and 1-4% of a film-forming material. According to the invention, the technical problem caused by large dose and small weight of tablets is thoroughly solved through a one-step granulation and coating technique; a medicine release curve similar to that of imported medicines is acquired; and the industrial production is facilitated.

Description

technical field [0001] The invention relates to a carlevodopa slow-release tablet and a preparation method thereof. Background technique [0002] Parkinson's disease (Parkinsonism disease, PD), also known as "parkinsonism", is one of the most common neurological diseases, mainly due to the degeneration of the substantia nigra-striatum system in the brain, resulting in a lack of dopamine content, which leads to cone In vitro system dysfunction. [0003] Levodopa is the precursor of dopamine, which enters the central nervous system through the blood-cerebrospinal fluid barrier, and is converted into dopamine by decarboxylase, thereby improving the symptoms of Parkinson's disease such as rigidity, slow movement, balance disturbance and tremor. When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small fraction of the administered dose is transported unchanged to the central nervous system. Carbidopa is a periph...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K9/22A61K47/38A61P25/16
Inventor 王传跃何书麟李黄强
Owner 浙江美华鼎昌医药科技有限公司
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