Nano-hybrid drug carrier prepared through Pickering emulsion template method with magadiite serving as emulsifier and preparation method of nano-hybrid drug carrier

A technology of magadiite and emulsion template method, which is applied in the direction of drug delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as damage to emulsion application, application restrictions, and human injury , to achieve the effect of reducing phagocytosis, easy operation and improving loading efficiency

Inactive Publication Date: 2017-12-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive non-food-grade traditional emulsifiers must be removed from the sample, otherwise it will cause harm to the human body, affect and destroy the subsequent application of the emulsion, such as emulsifiers can induce tissue inflammation and even cause cell damage, which makes emulsifiers prepared The application of traditional emulsions in pharmaceutical preparations is limited

Method used

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  • Nano-hybrid drug carrier prepared through Pickering emulsion template method with magadiite serving as emulsifier and preparation method of nano-hybrid drug carrier
  • Nano-hybrid drug carrier prepared through Pickering emulsion template method with magadiite serving as emulsifier and preparation method of nano-hybrid drug carrier
  • Nano-hybrid drug carrier prepared through Pickering emulsion template method with magadiite serving as emulsifier and preparation method of nano-hybrid drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 5g magadiite (see SEM image Figure 3a ) and 1g of hexadecyltriphenylphosphonium bromide were put into a 500ml beaker, and 100ml of deionized water was added, and the beaker was placed in a magnetic stirring water bath and stirred at 80°C for 24 hours. After the reaction was completed, The product was filtered and washed 3 times with deionized water, and the resulting filtrate was dried at 80°C for 6h, and then ground to obtain organic magadiite (see SEM image in Figure 3b ). Weigh 2mg of levonorgestrel, 1g of organic magadiite and 1g of PLGA, mix and dissolve in 50ml of ethyl acetate, put them in a 100ml beaker after mixing, put them in a magnetic stirring water bath and stir at room temperature for 6h After that, put it in an ultrasonic environment (40KHz) for 3 hours, and then add it to deionized water, with a water-to-oil volume ratio of 1:2. Mix ultrasound to obtain a stable and uniform milky white Pickering emulsion (polarized light microscope picture see...

Embodiment 2

[0043] Weigh 5g of magadiite and 1g of cetyltrimethylammonium bromide into a 500ml beaker, add 100ml of deionized water, place the beaker in a magnetic stirring water bath and stir at 80°C for 24 After the reaction was completed, the product was filtered and washed three times with deionized water, and the obtained filtrate was dried at 80° C. for 6 h, and then ground to obtain organic magadiite. Weigh 1g of organic magadiite and 1g of PLGA, mix and dissolve in 50ml of dichloromethane, put them in a 100ml beaker after ultrasonic mixing, dissolve 2mg of doxorubicin in 50ml of deionized water, separate the oil phase and the water phase Mixed, the volume ratio of water to oil is 2:1, and placed in an ultrasonic environment (40KHz) for 3 hours to obtain a stable milky white Pickering emulsion. Afterwards, the dichloromethane in the oil phase was removed by solvent evaporation, and finally dried under vacuum at 80° C. to obtain a nano-hybrid drug controlled-release membrane contain...

Embodiment 3

[0045] Weigh 5g of magadiite and 1g of hexadecyl trimethyl quaternary phosphonium salt into a 500ml beaker, add 100ml of deionized water, place the beaker in a magnetic stirring water bath and stir at 80°C for 24 hours , after the reaction was completed, the product was filtered and washed three times with deionized water, and the obtained filtrate was dried at 80° C. for 6 h, and then ground to obtain organic magadiite. Weigh 2mg of 5-fluorouracil, 1g of organic magadiite and 1g of PLGA, mix and dissolve in 50ml of ethyl acetate, mix them uniformly by ultrasonic, put them in a 100ml beaker, put them in a magnetic stirring water bath and stir at room temperature for 6h After that, place it in an ultrasonic environment (40KHz) for 3 hours, and then add it to deionized water, with a water-to-oil volume ratio of 8:9. Stable and uniform milky white Pickering emulsion was obtained by mixing with ultrasound, and the ethyl acetate in the oil phase was removed by solvent evaporation, ...

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Abstract

The invention discloses a nano-hybrid drug carrier prepared through a Pickering emulsion template method with magadiite serving as an emulsifier and a preparation method of the nano-hybrid drug carrier. According to the preparation method, the magadiite serves as the emulsifier, an organic solvent capable of dissolving and dispersing PLGA serves as an oil phase to prepare a Pickering drug emulsion, and the PLGA-magadiite nano-hybrid drug controlled-release carrier is prepared through the solvent evaporation method. The drug carrier has the advantages that drug degradation is decelerated, the situation that a drug is phagocytosed by a reticuloendothelial phagocytosis system is reduced, the bioavailability is improved, the body circulation time is prolonged, and cell permeability is improved; the Pickering emulsion serves as the template, and compared with a traditional emulsion, the advantages of being free of pollution, environmentally friendly, small in toxic effect on human bodies, high in stability and the like are achieved; and by adjusting the concentration of the nano-particle emulsifier or the oil-water ratio of the emulsion, size regulating on emulsion particles is achieved, and the drug loading efficiency can be improved.

Description

technical field [0001] The invention relates to the field of drug carriers, in particular to a nano-hybrid drug carrier prepared by a Pickering emulsion template method using magadiite as an emulsifier and a preparation method thereof. Background technique [0002] Traditional drugs have no controlled release and tissue specificity. After administration, the drug is released in large quantities at the initial stage, which brings harm to the body, and the systemic release of the drug also causes damage to normal organs and tissues; at the same time, the body decomposes and excretes the drug quickly, resulting in only multiple administrations. Only in this way can the drug concentration reach a certain therapeutic level, which is especially common in the chemotherapy process of cancer patients. Therefore, it is of great practical significance to make these drugs into sustained-release preparations to protect their structures from being damaged by the surrounding environment, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/24A61K47/34A61K31/57A61K31/704A61K31/513
CPCA61K9/0002A61K9/5123A61K9/5153A61K31/513A61K31/57A61K31/704A61K9/5115
Inventor 戈明亮曹罗香
Owner SOUTH CHINA UNIV OF TECH
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