Preparation method for hollow polymer nanofibers

A nanofiber and polymer technology, which can be used in the manufacture of hollow filaments, single-component synthetic polymer rayon, fiber processing, etc. The effect of repeated use, mild preparation conditions and high mechanical strength

Active Publication Date: 2012-10-17
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Nanofibers with hollow structures have unique advantages in the fields of embedding and controlled release of bioactive substances and drugs, but the current preparation methods are usually complicated, especially the activity of bioactive substances cannot be guaranteed during the preparation process.

Method used

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  • Preparation method for hollow polymer nanofibers
  • Preparation method for hollow polymer nanofibers
  • Preparation method for hollow polymer nanofibers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Thoroughly mix glycerin and water at a volume ratio of 95:5, add to a 5ml injector as the internal phase electrospinning solution for coaxial co-spinning; dissolve polyurethane in N,N-dimethylacetamide, Fully dissolve and make a solution with a weight percentage of 20%, as the external phase electrospinning solution, add it to another 5ml sampler; connect the internal and external phase electrospinning solutions to the inlet of the coaxial electrospinning spinneret through pipelines respectively. Liquid port, connect the liquid outlet of the spinneret to the positive pole of the high-voltage power supply, and use aluminum foil or stainless steel mesh to connect to the negative pole of the high-voltage power supply as a receiving plate. Adjust the distance between the spinneret and the receiving plate to be 15cm, and the voltage to be 15Kv. A syringe pump was used to control the flow rate of the inner phase electrospinning liquid to 0.05ml / h, and the flow rate of the out...

Embodiment 2

[0037] Thoroughly mix glycerin and water at a volume ratio of 95:5, add to a 5ml injector as the internal phase electrospinning solution for coaxial co-spinning; dissolve polyurethane in N,N-dimethylacetamide, Fully dissolve and make a solution with a weight percentage of 20%, as the external phase electrospinning solution, add it to another 5ml sampler; connect the internal and external phase electrospinning solutions to the inlet of the coaxial electrospinning spinneret through pipelines respectively. Liquid port, connect the liquid outlet of the spinneret to the positive pole of the high-voltage power supply, and use aluminum foil or stainless steel mesh to connect to the negative pole of the high-voltage power supply as a receiving plate. Adjust the distance between the spinneret and the receiving plate to be 17cm, and the voltage to be 25Kv. A syringe pump was used to control the flow rate of the inner phase electrospinning liquid to 0.07ml / h, and the flow rate of the out...

Embodiment 3

[0039] Thoroughly mix glycerin and water at a volume ratio of 90:10, add to a 5ml injector as the internal phase electrospinning solution for coaxial co-spinning; dissolve polyurethane in N,N-dimethylacetamide, Fully dissolved and made into a solution with a weight percentage of 25%, as the external phase electrospinning solution, added to another 5ml sampler; the internal and external phase electrospinning solutions were respectively connected to the inlet of the coaxial electrospinning spinneret through pipelines. Liquid port, connect the liquid outlet of the spinneret to the positive pole of the high-voltage power supply, and use aluminum foil or stainless steel mesh to connect to the negative pole of the high-voltage power supply as a receiving plate. Adjust the distance between the spinneret and the receiving plate to be 17cm, and the voltage to be 25Kv. A syringe pump was used to control the flow rate of the inner phase electrospinning liquid to 0.1ml / h, and the flow rat...

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Abstract

The present invention provides a method for preparing hollow polymer nanofibers by using a coaxial electrospinning technology. The method comprises the following steps: 1) adopting glycerol or a mixture of glycerol and water as an inner phase electrospinning liquid of coaxial electrospinning; 2) adopting a polymer solution as an outer phase electrospinning liquid; 3) respectively connecting the inner phase electrospinning liquid and the outer phase electrospinning liquid to a liquid inlet of a coaxial electrospinning nozzle; 4) controlling flow rates of the inner phase electrospinning liquid and the outer phase electrospinning liquid, and carrying out coaxial electrospinning to obtain the hollow polymer nanofibers on a receiving plate. Compared with the existing preparation technology, the preparation method of the present invention has the following advantages that: the liquid glycerol is adopted as the inner phase electrospinning liquid so as to prepare the hollow nanofibers through a one-step method, such that the preparation process is simple; the glycerol provides good biocompatibility for most of bioactive macromolecules, and bioactive substances such as biological enzymes and the like are added to the inner phase electrospinning liquid, such that efficient in-situ loading of the bioactive substances in the hollow nanofiber cavity can be achieved.

Description

technical field [0001] The invention relates to the technical field of polymer nanomaterial preparation, in particular to a method for preparing hollow polymer nanofibers by coaxial co-spinning electrospinning technology. Background technique [0002] With the development of the economy, the application fields of nanofibers are becoming more and more extensive, and its demand is also increasing year by year. Nanofibers in the strict sense are nanoscale fibers, generally referring to fibers with a diameter less than 100 nm. When the diameter of the fiber is reduced from micron to nano, some unique properties will appear, such as a large specific surface area, a high aspect ratio, and strong interpenetration with other substances. These excellent properties make nanofibers play an important role in applications such as biomedicine, biochemical protection, high-efficiency filtration, energy storage, and immobilized enzymes. [0003] There are also many ways to prepare nanofib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/94D01F6/48D01F6/92D01F6/52D01D5/00D01D5/24A61K9/00A61K47/34A61K47/32
Inventor 张松平姬晓元苏志国王平
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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