Preparation method of multi-coating drug eluting intravascular stent

A vascular stent and multi-layer coating technology, which is applied in the field of medical devices, can solve the problems of high thrombus formation rate, and achieve the effects of high production efficiency, good biocompatibility, and good sustained-release effect

Inactive Publication Date: 2014-02-12
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Drugs such as rapamycin (RAPM), paclitaxel (PTX), docetaxel, and everolimus can significantly inhibit postoperative smooth muscle cell proliferation and prevent restenosis caused by excessive neointimal hyperplasia, but late thrombosis rate is still high

Method used

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  • Preparation method of multi-coating drug eluting intravascular stent
  • Preparation method of multi-coating drug eluting intravascular stent
  • Preparation method of multi-coating drug eluting intravascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In this embodiment, the first layer of paint is a chitosan acetate solution of the platelet membrane glycoprotein receptor IIIa antagonist sz-21, and the third layer of paint is a solution of rapamycin and PLLA, which are sprayed under corresponding experimental conditions. The specific operation process is as follows:

[0025] (1) Put the 316L stainless steel bare metal bracket into 75% ethanol solution, acetone, and distilled water for 5-10 minutes, and then put it into 75% ethanol solution, acetone, and distilled water for 5-10 minutes to remove the residual oil, dust and other impurities on the surface of the bracket, and then soak it in chromic acid lotion 10-20min, then thoroughly cleaned with distilled water for 20min by ultrasonic vibration, and then dried in a vacuum oven at 50°C for 24 hours.

[0026] (2) Take by weighing 5mg sz-21 powder and be dissolved in 5ml1% acetic acid solution, mix and make medicine solution, then take by weighing 5mg chitosan and diss...

Embodiment 2

[0034] The first coat of present embodiment is the chitosan acetic acid solution of pro-vascular growth factor VEGF, platelet membrane glycoprotein receptor IIIa antagonist sz-21, and the third coat is rapamycin and PLLA solution, under corresponding experimental condition down to spray. The specific operation process is as follows:

[0035] (1) Put the 316L stainless steel bare metal bracket into 75% ethanol solution, acetone, and distilled water for 5-10 minutes, and then put it into 75% ethanol solution, acetone, and distilled water for 5-10 minutes to remove the residual oil, dust and other impurities on the surface of the bracket, and then soak it in chromic acid lotion 10-20min, then thoroughly cleaned with distilled water for 20min by ultrasonic vibration, and then dried in a vacuum oven at 50°C for 24 hours.

[0036](2) Dissolve 1mg VEGF and 5mg sz-21 powder in 5ml 1% acetic acid solution, mix well to make a drug solution, then weigh 5mg chitosan and dissolve it in th...

Embodiment 3

[0044] The first coat of present embodiment is the chitosan acetic acid solution of pro-vascular growth factor VEGF, platelet membrane glycoprotein receptor IIIa antagonist sz-21, and the third coat is docetaxel and PLLA solution, under corresponding experimental conditions down to spray. The specific operation process is as follows:

[0045] (1) Put the 316L stainless steel bare metal bracket into 75% ethanol solution, acetone, and distilled water for 5-10 minutes, and then put it into 75% ethanol solution, acetone, and distilled water for 5-10 minutes to remove the residual oil, dust and other impurities on the surface of the bracket, and then soak it in chromic acid lotion 10-20min, then thoroughly cleaned with distilled water for 20min by ultrasonic vibration, and then dried in a vacuum oven at 50°C for 24 hours.

[0046] (2) Dissolve 1mg VEGF and 5mg sz-21 powder in 5ml 1% acetic acid solution, mix well to make a drug solution, then weigh 5mg chitosan and dissolve it in ...

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Abstract

The invention aims at providing a method for preparing a multi-drug multi-coating eluting intravascular stent through ultrasonic atomizing and spraying, wherein VEGF, SZ-21 and other protein drugs, taking chitosan as a drug carrier, form a first coating; the second layer is a shielding layer, which adopts a polymer poly L lactic acid (PLLA) and can be added with polyethylene glycol (PEG) in different proportions to control release speed of drug; the third layer is lipid soluble medicine, such as rapamycin, which uses PLLA as a drug carrier; and a coating at the top end of the fourth layer, same as the second layer, is a shielding layer. Two uniform drug polymer coatings can simultaneously load multiple drugs, and the release speed of the drug can be regulated and controlled by regulating a mixing proportion of the PEG and the polymer, so as to inhibit restenosis and to reduce formation of thrombus simultaneously.

Description

technical field [0001] The invention relates to a method for preparing a multi-layer coating vascular stent by ultrasonic atomization spraying, in particular to a coating preparation technology for controlled drug release, and belongs to the technical field of medical devices. Background technique [0002] In recent years, percutaneous coronary intervention (PCI) has become the main treatment for coronary heart disease. More than 2 million patients worldwide receive this treatment every year, and the number of people receiving coronary intervention in my country has also exceeded 300,000 and showing a rapid growth trend year by year. PCI has been widely used to expand the inner diameter of stenosis to ensure normal blood circulation, but a considerable number of patients have in-stent restenosis (ISR) or other vascular blockage problems after surgery. The clinical efficacy of PCI has also been continuously improved, especially since Drug-eluting stents (DES) were used clinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/10A61L31/16
Inventor 王贵学饶琼胡廷章尹铁英王亚洲杜若林
Owner CHONGQING UNIV
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