The invention discloses a low-twist, high-strength and little-fuzz yarn production method and yarn. The method includes the opening picking process, the cotton carding process, the fine carding process, the drawing process, the roving process and the yarn spinning process. A larger-diameter and narrow-groove negative pressure hollow roller and a corresponding air draft assembly are adopted for the method, and therefore generated fuzz can be effectively reduced; under the condition that a mechanical friction twist device is adopted in the yarn spinning segment to reduce the twist coefficient by 15-30%, the single yarn strength is kept unchanged, polyester filament yarn serves as core silk so that the kind adaptability of the yarn can be effectively improved, the yarn strength is enhanced, the rotating direction of the twist device is opposite to that of a spindle, the twist stopping effect can occur, the width of a twisting triangular area is increased, the wrapping effect of core yarn is favorable for being improved, and a foundation is laid for developing fabric with good soft comfort. The low-twist, high-strength and little-fuzz yarn is produced with the method. Under the condition that the designed twist coefficient is reduced by 16-28%, compared with a normal designed twist coefficient, the strength is improved by 3-5%, resultant yarn is 3mm or longer, and the harmful fuzz is reduced by 80-95% compared with harmful fuzz in ring spun yarn.