279 results about "Poly l lactic acid" patented technology

The invention belongs to the technical field of drug delivery, and particularly relates to an M-coated PLGA-10BX compound as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing 10B-enriched boron nitride (h-10BN); extracting a cell membrane of the macrophage RAW264.7; polylactic acid-glycolic acid copolymer (PLGA) nano particles loaded with h-10BN are prepared; and finally, the bionic nano platform M (at) PLGA-10BN based on the macrophage membrane is prepared. The bionic nano-platform prepared by the invention is uniform in particle size and morphology, has relatively high biological safety, and has no obvious damage to various tissues and visceral organs. The compound can be used as a general platform for boron compound delivery, can also be used as an immune activator, is suitable for intravenous injection administration, and expands the application of boron neutron capture therapy (BNCT) in treatment of glioblastoma (GBM).

The invention discloses a modified polylactic acid fiber and a preparation method thereof. The preparation method comprises the following steps: providing polybasic hydroxyl-terminated D-polylactic acid; the method comprises the following steps: respectively providing betaine-grafted D-polylactic acid and a poly (butylene adipate terephthalate)-epoxy-polyether co-modified organic silicon-D-polylactic acid copolymer by taking the multi-hydroxyl-terminated D-polylactic acid as a main raw material, wherein the poly (butylene adipate terephthalate)-epoxy-polyether co-modified organic silicon-D-polylactic acid copolymer; and carrying out Haake blending and melt spinning on the betaine-grafted D-polylactic acid, a poly (butylene adipate-co-modified organosilicon-D-polylactic acid) copolymer, L-polylactic acid, an antioxidant and an anti-hydrolysis agent, so as to obtain the modified polylactic acid fiber. The preparation method comprises the following steps: carrying out Haake blending and melt spinning on the betaine-grafted D-polylactic acid, poly (butylene adipate-co-modified organosilicon-D-polylactic acid copolymer, L-polylactic acid, the antioxidant and the anti-hydrolysis agent. The modified polylactic acid fiber prepared by the method has the characteristics of easy decontamination, hydrophilicity, high temperature resistance and high toughness, and can effectively avoid water washing shedding, and the comprehensive performance is obviously improved.

The invention discloses a cellulose microcrystal reinforced degradable flame-retardant PLA composite material and a preparation method thereof, and belongs to the field of bio-based functional polymer materials. The composite material is prepared from the following components in parts by weight: 80 to 100 parts of polylactic acid (PLA), 3 to 10 parts of bamboo cellulose microcrystal, 3 to 10 parts of biomass polyphosphate, 1 to 5 parts of GO-g-PLA, 10 to 30 parts of PBAT toughening agent and 0.2 to 1 part of auxiliary agent. The preparation method comprises the following steps: (1) preparing high-crystallinity bamboo cellulose microcrystals by adopting a supercritical CO2 method; (2) preparing a GO-g-PLA interface compatilizer through graft polymerization; (3) synthesizing a biomass polyphosphate flame retardant by taking pentaerythritol and diphenolic acid as raw materials; and (4) melting, blending and extruding the components. Through the synergistic effect of a flame retardant-GO-BCMC three-dimensional network, the material has excellent mechanical properties (the tensile strength is 45-47 MPa, and the impact strength is 10-12 kJ / m), high flame retardance (LOI is 28-29%, UL-94 V-0 level) and environmental friendliness (the 180-day biodegradation rate gt); the composite material can be widely applied to the fields of electronic and electric appliances, automotive trim, medical materials and the like.

The invention relates to an absorbable bone hemostasis and repair stent. The absorbable bone hemostasis and repair stent comprises the following raw materials in parts by weight: 15-60 parts of an excipient, 15-60 parts of a softening agent and 5-70 parts of a bone repair promoting component, the excipient is prepared from a polyoxyethylene-polyoxypropylene copolymer; the softening agent comprises a semi-solid mobile phase polymer; the bone repair promoting component comprises a coating and a core, the coating comprises a polylactic acid-glycolic acid copolymer, zinc stearate and potassium bromide, the core comprises calcium phosphate particles, and the coating wraps the surface of the core. The preparation method comprises the following steps: preparing the bone repair promoting component; and preparing the absorbable bone hemostasis repair stent. The absorbable bone hemostasis and repair stent is high in hemostasis and collapse resistance and has good inflammation regulation and bone repair promoting effects. The absorbable bone hemostasis and repair stent can be used for bone hemostasis and bone repair promotion of any bone injury wound.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

The invention provides a polylactic acid-polycitrate composite microsphere as well as a preparation method and application thereof. The polylactic acid-polycitrate composite microsphere is prepared from the following raw materials: a polycitrate prepolymer and poly-L-lactic acid. According to the polylactic acid-polycitrate composite microsphere provided by the invention, the polycitrate prepolymer is introduced, so that mechanical-degradation double-phase matching of a material can be realized, the hydrophobicity of the poly-L-lactic acid can be reduced, the hydrophilic-hydrophobic balance of the surface of the composite microsphere is realized, the affinity and biological activity of cells are improved, and the biocompatibility of the composite microsphere is improved. And the poly citrate prepolymer and the poly-L-lactic acid are matched for use, so that the whole polylactic acid-poly citrate composite microsphere has bionic viscoelasticity, thereby promoting the spreading of fibroblasts and the secretion of more integrin and collagen monomers, facilitating the behavior regulation and control of cells, and mildly stimulating the regeneration of collagen.

The invention relates to the technical field of pharmaceutical preparations, and discloses a high-drug-loading risperidone sustained release microsphere for subcutaneous injection and a preparation method thereof, and the preparation method comprises the following steps: mixing risperidone, polylactic acid and dichloromethane to obtain an oil phase; dissolving a pore-forming agent in water to obtain a pore-forming agent solution; mixing polyvinyl alcohol, sodium chloride and water to obtain a water phase; mixing the oil phase with the pore-forming agent solution to obtain primary emulsion; mixing and stirring the primary emulsion and a water phase until dichloromethane is completely volatilized to obtain microspheres loaded with speridone; mixing cellulose acetate, polyethylene glycol and an organic solvent to obtain a coating solution; and coating the risperidone-loaded microspheres with a coating solution to obtain the high-drug-loading risperidone sustained-release microspheres capable of being used for subcutaneous injection. According to the invention, the efficient drug loading is realized, the injection comfort is improved, the slow permeation and release of the drug are realized, and the onset speed and the long-acting treatment demand are balanced.

The present application relates to the technical field of surface treatment, in particular to a kind of biobased degradable cable material and preparation method thereof.Biobased degradable cable material includes 55-65 parts of poly-L-lactic acid and poly-3-hydroxybutyric acid-3-hydroxyhexanoate mixed matrix resin, 4-6 parts of dianhydride modified castor oil polyol, 10-15 parts of polyaminoval, 5-8 parts of nano enhanced filler, 6-10 parts of biobased plasticizer, 0.5-1.0 parts of antioxidant, 8-12 parts of environmentally friendly flame retardant.Dynamic ester bond crosslinking agent dianhydride modified castor oil polyol reaction forms dynamic ester bond crosslinking network, ester bond breakage occurs at high temperature beyond normal working range to release stress, temperature returns to normal and can recombine again;Semi-interpenetrating network enhanced phase polyaminoval forms interpenetrating structure with matrix resin in molecular chain interlacing mode, constructs stable heat-resistant skeleton, effectively inhibits high-temperature deformation, and its biobased structure ensures the overall degradability of the material, realizes the balance of heat resistance and degradability.

The invention discloses a polyhydroxyalkanoate composition and a preparation method thereof. The polyhydroxyalkanoate composition comprises the following components in parts by mass: 100 parts of polyhydroxyalkanoate; 0.5 to 5 parts of unsaturated D-polylactic acid; 0.5 to 5 parts of poly (L-lactic acid); the preparation method comprises the following steps: S1, carrying out melt blending on the polyhydroxyalkanoate and the unsaturated D-polylactic acid, and enabling the polyhydroxyalkanoate and the unsaturated D-polylactic acid to fully react, so as to obtain an intermediate product; and S2, carrying out melt blending on the intermediate product obtained in the step S1, poly-L-lactic acid and an ester exchange inhibitor to finally obtain the polyhydroxyalkanoate composition with excellent thermal stability, high melt strength and high crystallization speed.

The application discloses a functional probiotic microencapsulated intestinal shield system and a preparation method and application thereof. A core layer comprises four probiotics, i.e., lactobacillus acidophilus La-14, animal bifidobacterium Bb-12, lactobacillus rhamnosus GG and lactobacillus reuteri DSM 17938, and the weight ratio is 3:4:2:1, and the total viable bacterial count is greater than or equal to 10^10 CFU / g. An inner layer is a targeted release control layer, which is composed of ethyl cellulose, polylactic acid, chitosan and lactose, can swell in a pH 5.5 to 6.5 environment and can dissolve in a pH 6.8 to 7.2 environment. A middle layer is a buffer protection layer, which is composed of calcium carbonate, disodium hydrogen phosphate and sodium alginate, and can maintain the internal pH of the microcapsule at 4.5 to 5.5 in a gastric acid environment. An outer layer is an intelligent response protection layer, which is composed of konjac glucomannan, xanthan gum and gum arabic, and can form a protective film in a gastric acid environment with a pH less than 3.0 within 5 minutes. Through the synergistic protection of the four-layer microcapsule structure, the probiotics can achieve a high survival rate in the gastric acid environment of cats, and can be accurately released at specific positions in the intestinal tract, which is helpful to improve the intestinal health of cats.

The invention relates to the technical field of biomedical materials and wound repair, and discloses a preparation method and application of 4 '-hydroxychalcone-loaded nanofiber hydrogel, the preparation method comprises the following steps: mixing 4'-hydroxychalcone and polylactic acid according to a mass ratio of 1: (6-12), and carrying out ultrasonic treatment to obtain 4 '-hydroxychalcone-loaded nanofiber hydrogel; preparing nanofibers containing 4 '-hydroxychalcone by adopting an electrostatic spinning technology; according to the present invention, the 4 '-hydroxychalcone-loaded nanofiber hydrogel has the following characteristics that the drug in the 4'-hydroxychalcone-loaded nanofiber hydrogel can be continuously released, and the cumulative release rate can achieve 70-85% within 72 h so as to maintain the stable drug action concentration on the wound surface; meanwhile, the nanofiber hydrogel has good water retention capacity, the water retention rate of the nanofiber hydrogel can reach 90-95%, a stable wet healing environment can be provided for the wound surface, and the wound surface repairing process is facilitated.

The invention relates to the technical field of films, in particular to an optical composite film of a composite polylactic acid core layer and a preparation method of the optical composite film. The optical composite film is of a three-layer structure and comprises a composite polylactic acid core layer made of specific raw materials and amorphous polylactic acid skin layers on the two sides. The core layer is prepared from the following raw materials: poly (L-lactic acid) resin, poly (D-lactic acid) macromolecules, carboxyl-terminated poly (D-lactic acid) oligomers, a multifunctional epoxy chain amplification agent and aminated nano silicon dioxide. During preparation, key processes such as step-by-step addition of the chain extender, the D-lactic acid component and the aminated nano silicon dioxide and three-layer co-extrusion stretching are carried out, so that the molecular structure and the dispersion state of the material are synergistically optimized. The method effectively solves the technical contradiction that a traditional polylactic acid optical film is difficult to consider high light transmittance, low birefringence and low thermal shrinkage at the same time.

The application discloses a water-soluble quantum dot nanometer material and a preparation method and application thereof, and the nanometer material comprises quantum dots and carboxyl-terminated poly(lactic-co-glycolic acid) coated on surfaces of the quantum dots. The carboxyl-terminated poly(lactic-co-glycolic acid) is used for encapsulating CsPbBr3 perovskite quantum dots, and a water-soluble perovskite nanocrystal material is prepared, which can retain high quantum yield (PLQY=88%) and water-oxygen resistance (>=30 days) and almost completely retains optical performance of the perovskite quantum dots.

The application relates to the technical field of medical suture materials, and particularly discloses a non-absorbable suture with tissue self-adaptive performance, which comprises a core layer, a transition layer and an outer layer; the core layer and the transition layer are fixed through hot melt adhesion, and the outer layer is coated on the surface of the transition layer through electrostatic spinning; the core layer is a polyether ether ketone fiber with a diameter of 50-100 mu m and a tensile modulus of greater than or equal to 3 Gpa; the transition layer is a nickel-titanium alloy wire braided net with a thickness of 40-60 mu m, and the wire diameter of the nickel-titanium alloy wire is 20-30 mu m; and the outer layer is a poly-lactic acid-glycolic acid copolymer coating layer containing nano-hydroxyapatite with a thickness of 30-50 mu m; and the application further provides a preparation method of the non-absorbable suture. The non-absorbable suture has the advantages of tissue self-adaptive performance, persistent mechanical support and bioactivity, can effectively avoid tissue cutting, abrasion and suture loosening, and can reduce the incidence of postoperative complications such as inflammation and pain.

The present disclosure concerns a polymer selected from poly-L-lactic acid, poly-D, L-lactic acid and any copolymer comprising repeating units comprising L-lactic acid, or any combination thereof, for use in preventing and / or treating any damage, disease, illness, and / or condition characterized by hair loss. Compositions comprising said polymer are also disclosed for said use.

The invention provides a cardiac targeting nano drug delivery carrier based on recombinant apolipoprotein, a system, a preparation method and application. The cardiac targeting nano drug delivery carrier comprises a nano carrier core and a functional layer covalently coupled to the surface of the nano carrier core, the nano carrier core comprises an amphiphilic copolymer formed by polylactic acid-glycolic acid and polyethylene glycol; the functional layer comprises recombinant apolipoprotein A-I and heart targeting peptide; the recombinant apolipoprotein A-I contains mutation sites E191A and F225W, and the recombinant apolipoprotein A-I contains mutation sites F225W; the amino acid sequence of the recombinant apolipoprotein A-I is as shown in SEQ ID NO: 1. The cardiac targeting nano drug delivery system based on the recombinant apolipoprotein has the functions of long circulation, cardiac targeting and coordinated regulation and control of metabolism and inflammation, and can be used for precise treatment of chronic heart failure.

The invention discloses a hydrogel composition for three-dimensional culture of tumor cells and a preparation method of the hydrogel composition. The hydrogel composition is prepared from poly (lactic acid-glycolic acid) copolymer-polyethylene glycol-poly (lactic acid-glycolic acid) copolymer PLGA-PEG-PLGA and methylacryloyl gelatin GelMA, the mass ratio of the poly (lactic acid-glycolic acid) copolymer-polyethylene glycol-poly (lactic acid-glycolic acid) copolymer PLGA-PEG-PLGA to the methylacryloyl gelatin GelMA is (2-5): 10. According to the hydrogel composition, methacrylated gelatin GelMA is used as a main substrate, so that good biocompatibility and cell adhesion are provided; according to the invention, polylactic acid-glycolic acid copolymer-polyethylene glycol-polylactic acid-glycolic acid copolymer PLGA-PEG-PLGA is used as an auxiliary component, lactic acid is generated through biodegradation of the polylactic acid-glycolic acid copolymer-polyethylene glycol-polylactic acid-glycolic acid copolymer-PEG-PLGA, the pH of a microenvironment is dynamically reduced to 6.5-6.9, tumor acidic conditions are simulated, and pores formed after degradation can provide more growth and invasion spaces for tumor cells.

The invention provides a long-acting microsphere sustained release preparation and a preparation method thereof, and belongs to the technical field of sustained release preparations, the long-acting microsphere sustained release preparation is prepared from the following raw materials of effective components: 9.5 to 10.5 parts of antipsychotic drug, 48 to 50 parts of hydroxypropyl-beta-cyclodextrin, 50 to 52 parts of polylactic acid-glycolic acid copolymer, 1.25 to 1.3 parts of glycerol triacetate and 10 to 11 parts of polyvinyl alcohol. The preparation method comprises the following steps: firstly, the hydroxypropyl-beta-cyclodextrin is used for clathration of the antipsychotic drug, the obtained clathrate compound is further clathrated by the polylactic acid-glycolic acid copolymer, and the long-acting microsphere sustained release preparation is obtained. According to the invention, the double-valve design of beta-CD and PLGA synergistic inclusion is utilized, so that the preparation can realize two-stage release; the macroscopic slow release characteristic of the PLGA is combined with the microcosmic express characteristic of the hydroxypropyl-beta-cyclodextrin, so that the technical limitation of a single carrier is broken through.

Provided is a poly(lactic acid-b-3-hydroxypropionic acid) block copolymer in which transparency is improved by introducing a 3-hydroxypropionic acid-derived monomer into a polylactic acid, and thus its application field can be expanded.

The application discloses a method for recovering lactic acid methyl ester by catalytic depolymerization of polylactic acid in one pot. The method comprises the following steps: mixing polylactic acid, amine nitrogen ligand and methanol, dissolving by adding a solvent, and then adding a n-butyllithium solution to carry out a depolymerization reaction; and after the reaction is completed, the solvent is removed by vacuum distillation, and the crude product is dried in vacuum to obtain lactic acid methyl ester product. The application does not need to synthesize a complex organic metal catalyst, the depolymerization condition is mild, and the generation of by-products such as low-molecular-weight oligomers is effectively reduced. Therefore, the application has the advantages of simplifying the catalyst preparation process, improving the depolymerization efficiency, reducing the cost and the like, and is suitable for industrialized recovery and cyclic utilization of polylactic acid.

This invention discloses a method for preparing self-healing concrete based on microbial gene programming, belonging to the field of building materials technology. The method includes: constructing a recombinant engineered strain incorporating a urease gene cluster and a carbonic anhydrase gene; preparing a spore suspension and protecting it with a three-layer microencapsulation system of sodium alginate / chitosan / gelatin; preparing nutrient-releasing microspheres encapsulating calcium lactate and urea in a polylactic acid-glycolic acid copolymer; and mixing cement, standard sand, water, fly ash, microencapsulated spore particles, nutrient-releasing microspheres, nano-silica, and modified bentonite to prepare self-healing concrete. This invention enhances the urease activity of the strain through genetic engineering, protects the spores using a three-layer microencapsulation technology, and combines a nutrient-releasing system and nano-synergists to achieve efficient self-repair of concrete cracks.

The application provides a degradable material, which comprises poly(lactic acid-amino acid) / polycaprolactone microspheres; the poly(lactic acid-amino acid) / polycaprolactone microspheres are prepared by blending poly(lactic acid-amino acid) and polycaprolactone; the proportion of poly(lactic acid-amino acid) and polycaprolactone in the poly(lactic acid-amino acid) / polycaprolactone microspheres is (1-10):(1-10); the polymerization monomers of the poly(lactic acid-amino acid) comprise lactide and amino acid, and the proportion of the lactide and the amino acid is (2-10):1; the median particle size D50 of the poly(lactic acid-amino acid) / polycaprolactone microspheres is 30-300 mu m, and the particle size distribution is less than 1.0. The poly(lactic acid-amino acid) / polycaprolactone microspheres provided by the application solve the problems of slow degradation rate, poor hydrophilicity and mechanical property of the existing degradable material by introducing the hydrolysis bond group in the amino acid, and have good degradation performance and stability.

The application provides a preparation method and application of resveratrol-polylactic acid microspheres, and relates to the technical field of biological agents, quantitative resveratrol is dissolved in methanol as O1 phase; quantitative polylactic acid is dissolved in an oil phase solution (ethyl acetate, dichloromethane, trichloromethane) as O2 phase; ammonium bicarbonate, sodium bicarbonate, sodium chloride and hydrogen peroxide are used as a porogen; O1 phase, O2 phase and the porogen solution are subjected to ultrasonic emulsification to obtain O / O primary emulsion; the O / O primary emulsion is added to a polyvinyl alcohol aqueous solution under stirring to obtain O / O / W multiple emulsion; the obtained O / O / W multiple emulsion is subjected to mechanical stirring to remove the oil phase solution in the O / O / W multiple emulsion, and then is subjected to standing, centrifugation, washing, drying and the like to obtain resveratrol-polylactic acid microspheres with uniform size. The resveratrol-polylactic acid microspheres of the application break through the bottleneck of poor water solubility of resveratrol, can effectively prolong the drug action time, and have good antibacterial effect.

This invention discloses a penicillin V potassium capsule and its preparation method. The preparation method includes: preparing modified polylactic acid glycolic acid copolymer microspheres; mixing penicillin V potassium micropowder with the modified polylactic acid glycolic acid copolymer microspheres, adding fumed silica and anhydrous calcium hydrogen phosphate for further mixing to obtain a blend; granulating the blend using a dry granulation method; filling the obtained granules into capsules, polishing, and packaging; and modifying the polylactic acid glycolic acid copolymer with povidone and ethyl cellulose to obtain the modified polylactic acid glycolic acid copolymer microspheres. This invention designs polylactic acid glycolic acid copolymer microspheres that are double-modified with povidone and ethyl cellulose, resulting in better drug loading flowability, more stable mixing uniformity, and significantly improved flowability compared to penicillin V potassium powder. The addition of fumed silica and anhydrous calcium phosphate further enhances antistatic properties and reduces the powder return rate.

The invention relates to an environment-friendly soil stabilizer which comprises the following components in parts by weight: 10-40 parts of modified polylactic acid, 30-60 parts of wheat straw liquid, 5-20 parts of colloid, 30-60 parts of linseed oil, 15-20 parts of sodium alginate, 10-12 parts of rosin, 25-50 parts of filler and 1-2 parts of sucrose. By adopting the technical scheme, natural components in the wheat straw liquid are combined with a film formed by polylactic acid, so that the crack resistance and durability of soil can be enhanced, the moisture retention capacity of the soil can be improved, and the environmental protection property of the soil stabilizer can be improved by mixed use; the colloid improves the stability and moisture retention capacity of soil, the linseed oil improves the overall structural stability and cohesiveness of the soil and reduces soil cracking, the sodium alginate improves the cohesiveness and overall stability of the soil, the sodium alginate can help to reduce the cracking of the soil and reduce the influence of soil exposure cracking, and the rosin improves the hardness and the adhesiveness, so that the anti-cracking performance of the soil is improved. The cane sugar serving as a component of the soil stabilizer can enhance the cohesiveness and stability of the soil, promote the microbial activity and improve the soil structure at the same time.

The present application relates to a kind of cat rhinotracheitis, feline calicivirus disease, cat pancytopenia triple subunit vaccine, preparation method and its application.The present application is expressed antigen protein using CHO cell strain, and synergistic effect is combined molecular adjuvant (IL-2, GM-CSF, CpG) with MF59 nanoemulsion, molecular adjuvant composition is adsorbed on the surface of MF59 nanoemulsion, then embedded in polylactic acid-glycolic acid copolymer microsphere, mixed with triple subunit protein to form vaccine preparation.The vaccine prepared in the present application can stimulate humoral immunity and cellular immunity simultaneously by subcutaneous or intramuscular injection, significantly improve antibody titer and attack protection rate, prolong immune protection period, and reduce injection site adverse reactions.The synergistic effect of protein and molecular adjuvant and MF59 makes the vaccine superior to traditional subunit vaccine in safety, stability and immunological efficacy, and is suitable for high-efficiency prevention of three viral infectious diseases in feline.

The application discloses a dehydrogenation catalyst and a synthesis method and application thereof. The synthesis method of the catalyst comprises the following steps: (1) mixing soluble copper salt, soluble zinc salt and soluble aluminum salt with dichloromethane and ethanol to obtain a mixed solution containing copper, zinc and aluminum, and then adding polylactic acid and stirring to obtain a spinning solution; (2) using a coaxial electrostatic spinning nozzle to electrostatically spin the spinning solution obtained in the step (1) and collecting a solid; (3) placing the solid obtained in the step (2) in an ethanol solution of trimesic acid to perform a reaction, and then washing and drying the catalyst precursor after the reaction is completed; and (4) calcining and post-treating the catalyst precursor obtained in the step (3) to obtain the catalyst. The catalyst obtained by the method has high conversion rate and selectivity in the reaction of dehydrogenating 1,4-butanediol to prepare gamma-butyrolactone.

The method for analyzing the content of D-lactic acid repeating units in polylactic acid of the present disclosure is characterized in that without special chemical treatment of polylactic acid, the content of D in polylactic acid can be quickly and accurately analyzed by using NMR data of polylactic acid and hypothetical polylactic acid.

The invention discloses a novel RNA (Ribonucleic Acid) nano vaccine for preventing and treating colorectal cancer as well as a preparation method and application of the novel RNA nano vaccine. According to the nano vaccine, biodegradable polylactic acid-glycolic acid copolymer nano particles are taken as a carrier, and full-tumor cell RNA is encapsulated by a multiple emulsion solvent evaporation method to form the nano vaccine RNA (at) PLGA; the nano vaccine can effectively protect RNA, shows an excellent tumor inhibition effect and good safety in an animal model, can reverse the immunosuppression state of a tumor microenvironment, and provides a new effective strategy for immunotherapy of colorectal cancer.

Embodiments relate to a method for manufacturing a screen fabric to be installed in a golf simulator, the method including: a step of manufacturing a fabric body having a predetermined area by processing a biodegradable resin (poly(lactic acid) (PLA)) into yarn and weaving the yarn; and a coating step of applying a coating solution to at least one of both surfaces of the fabric body to form a coating layer, wherein at least one gap exposing the fabric body is formed in the coating layer.