578 results about "Poly l lactic acid" patented technology

The invention discloses a preparation method of a curing agent with biological self-healing capability, which comprises the following steps: preparing a bacillus pasteurii bacterial solution, preparing the bacillus pasteurii bacterial solution into an endophytic spore solution, immersing polyvinyl alcohol fibers into a sodium alginate / endophytic spore solution, taking out the polyvinyl alcohol fibers, immediately immersing the polyvinyl alcohol fibers into a calcium acetate solution, drying the polyvinyl alcohol fibers to obtain core fibers with a hydrogel coating, and curing the core fibers with the hydrogel coating to obtain the curing agent with biological self-healing capability. The preparation method comprises the following steps: taking magnesium phosphate cement as a raw material, immediately immersing the magnesium phosphate cement into a chloroform solution of a polystyrene and polylactic acid polymer blend, drying to obtain a coated microbial liquid, premixing urea and glucose, doping the premixed urea and glucose into the magnesium phosphate cement, uniformly stirring, adding the coated microbial liquid, and uniformly stirring to obtain the product. According to the invention, phosphate cement is adopted as the curing agent, has the advantages of high strength, short setting time, strong durability, low alkalinity, good biocompatibility and the like, and compared with the curing agent in the prior art, the curing agent not only has a good curing effect, but also has a crack self-healing function, and is especially suitable for reinforcing foundation soil.

The invention discloses an absorbable suture line for surgical suture and a preparation method thereof, and relates to the technical field of medical materials. The absorbable suture line for surgical suture is prepared from the following raw materials in parts by weight: 50 to 65 parts of polylactic acid, 15 to 20 parts of polyglycolic acid, 3 to 5 parts of sodium carboxymethyl cellulose, 3 to 8 parts of a toughening agent, 3 to 6 parts of an antibacterial agent, 0.3 to 0.8 part of a lubricating agent, 1 to 2 parts of sodium hyaluronate and 5 to 10 parts of polyvinyl alcohol. The toughening agent is obtained by reacting hydroxyethyl acrylate with ethylenediamine to generate a four-arm compound and then reacting with 6-caprolactone and DL-lactide. The absorbable suture line for surgical suture prepared by the invention has excellent tensile property and antibacterial property, and can meet the application requirements of clinical medical treatment.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention relates to medical recombinant collagen repair gel and a preparation method thereof, and belongs to the technical field of recombinant collagen. Through the synergistic effect of the collagen, the chitosan, the polylactic acid, the nanocellulose, the vascular endothelial growth factor, the anti-inflammatory drug and the cell adhesion peptide, the tissue repair effect is remarkably improved. Through a gas foaming method, staged freezing and freeze drying, multistage pore size distribution is generated, gel with a porous structure is formed, and cell permeation and tissue regeneration are facilitated; in addition, the permeability and the drug loading capacity of the gel are improved, the cell adhesion peptides, the growth factors and the anti-inflammatory drugs are better adsorbed to the gel, functional slow release is achieved, and the repairing effect is further improved.

The invention relates to the technical field of biomedical materials, in particular to an artificial bone composite material and a preparation method thereof. The preparation method of the artificial bone composite material comprises the following steps: sequentially adding a CaCl2 solution and a NaH2PO4 solution into a collagen solution in proportion. And adjusting the pH value to 7.4, and collecting white jelly. Dispersing the white jelly in distilled water to obtain a colloid I; respectively adding the colloid I and the modified polyether-ether-ketone powder into a dichloromethane solution containing poly-L-lactic acid in proportion to obtain a mixed solution II, and then adding an ethanol solution for precipitation; and removing the precipitate in the mixed solution II to obtain the slurry. Injecting the slurry into a mold to obtain an intermediate I, and soaking the intermediate I in an EDC / NHS ethanol solution for crosslinking; according to the preparation method, the artificial bone composite material with high mechanical strength and good biocompatibility can be prepared, the defect that the biocompatibility and mechanical strength resistance of the artificial bone composite material cannot be obtained at the same time in the prior art can be overcome, and the practicability of the artificial bone composite material is improved.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention relates to the technical field of biomedicine, and discloses a triclosan antibacterial coating surgical suture and a preparation method thereof.The suture comprises a base material and a surface antibacterial coating, the base material is selected from one of an absorbable single-strand material, an absorbable multi-strand material, a non-absorbable single-strand material and a non-absorbable multi-strand material, and the surface antibacterial coating is selected from one of an absorbable multi-strand material and a non-absorbable multi-strand material; the antibacterial coating comprises triclosan, a high-molecular carrier and an auxiliary agent, the surface energy of a hydrophobic material is improved, the porosity of a hydrophilic material is increased, the adhesive force between the coating and different base materials is ensured, the base materials can be covered, the uniformity deviation of the coating is avoided, and the coating is free of cracking or falling off through the combination of plasma cleaning and roughening treatment on the surface of the base materials. A synergistic system is formed by triclosan, nano-silver and titanium dioxide, a dual mechanism of targeted destruction of bacterial cell membranes and free radical oxidation is achieved, the antibacterial rate is increased, the MRSA inhibition rate is increased, the degradation rate is regulated and controlled through the polylactic acid-glycolic acid copolymer carrier molecular weight and the lactic acid / glycolic acid proportion, and a curing dynamic formula is combined.

The invention discloses an antihypertensive material for subcutaneous implantation and a preparation method of the antihypertensive material, and belongs to the technical field of biomedical materials. The antihypertensive material comprises a carrier material and a drug mixture loaded on the carrier material according to a mass ratio of (10-15): (5-8), and the carrier material comprises the following raw materials: polylactic acid-glycolic acid copolymer, citric acid-chitosan ester, genipin and a silicon dioxide active material. The silicon dioxide active material is obtained by compounding mesoporous silicon dioxide nanoparticles and a collagen coating on the surface of the mesoporous silicon dioxide nanoparticles. According to the antihypertensive material disclosed by the invention, a degradable skeleton is provided by the polylactic acid-glycolic acid copolymer, citric acid-chitosan ester is used as a toughening agent and an antibacterial material, genipin is used as a cross-linking agent, and a mesoporous structure of a silicon dioxide active material is used for loading a medicine; the problems that an existing subcutaneous implant material is high in burst release rate, poor in mechanical property, insufficient in biocompatibility and the like are solved.

The invention belongs to the technical field of biomedicine, and particularly relates to an alpha-cyperone bionic nano preparation as well as a preparation method and application thereof, the alpha-cyperone bionic nano preparation is prepared from a polylactic acid-glycolic acid copolymer, alpha-cyperone, a bionic membrane and follicle-stimulating hormone polypeptide, the biomimetic membrane is characterized in that alpha-cyperone is loaded on a polylactic acid-glycolic acid copolymer, the biomimetic membrane is biologically camouflaged on the outer layer, then the biomimetic membrane is modified by follicle-stimulating hormone polypeptide, and the amino acid sequence of the follicle-stimulating hormone polypeptide is as shown in SEQ ID NO.1. According to the alpha-cyperone bionic nano preparation disclosed by the invention, the alpha-cyperone is loaded by utilizing the polylactic acid-glycolic acid copolymer, so that the alpha-cyperone is easily dissolved in water, and the blood circulation half-life period is prolonged and the targeting capability of an ovary part is improved through biological camouflage of the bionic membrane; the modification of the follicle-stimulating hormone polypeptide further improves the targeting ability to granulosa cells, and liver and kidney toxicity and muscle injury are not found in the experiment process.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention discloses an anti-fibrosis drug coating degradable woven stent for treating urethrostenosis, the stent is a hollow cylinder formed by spirally weaving wires, the wires are made of biodegradable polymer materials, the surface of the stent is coated with a drug coating, anti-fibrosis drugs are selected as the drugs, and the anti-fibrosis drug coating is made of biodegradable polymer materials. The drug coating is prepared by using an ultrasonic atomization spraying method; the biodegradable polymer material comprises one or a compound of more than one of poly L-lactic acid, poly D, L-lactic acid, poly (L-lactic acid / D, L-lactic acid), poly (glycolide / lactide), poly (glycolide-lactide), poly (L-lactic acid / caprolactone), poly (glycolide / caprolactone), poly (D, L-lactic acid / caprolactone), polydioxanone and the like. The stent body is made into a self-expanding stent by adopting a weaving method; the biodegradable ureteral stent with the drug coating has good biocompatibility, degradability and mechanical property, and has a wide market application prospect.

The invention belongs to the technical field of drug delivery, and particularly relates to an M-coated PLGA-10BX compound as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing 10B-enriched boron nitride (h-10BN); extracting a cell membrane of the macrophage RAW264.7; polylactic acid-glycolic acid copolymer (PLGA) nano particles loaded with h-10BN are prepared; and finally, the bionic nano platform M (at) PLGA-10BN based on the macrophage membrane is prepared. The bionic nano-platform prepared by the invention is uniform in particle size and morphology, has relatively high biological safety, and has no obvious damage to various tissues and visceral organs. The compound can be used as a general platform for boron compound delivery, can also be used as an immune activator, is suitable for intravenous injection administration, and expands the application of boron neutron capture therapy (BNCT) in treatment of glioblastoma (GBM).

The application discloses a preparation method of a dopamine-coated poly(L-lactic acid) piezoelectric biomaterial, S1, ultrasonic dispersion of dopamine hydrochloride in an organic solvent is carried out to obtain a dopamine hydrochloride dispersion liquid; S2, poly(L-lactic acid) powder is added into the dopamine hydrochloride dispersion liquid and stirring is carried out to obtain an electrostatic spinning liquid; S3, bubbles in the electrostatic spinning liquid are removed, a nanofiber membrane is obtained through an electrostatic spinning process, high-temperature annealing is carried out on the nanofiber membrane, and cooling is carried out, so that the dopamine-coated poly(L-lactic acid) piezoelectric biomaterial is prepared. The preparation method adopts an interface anchoring effect, strong intermolecular interaction at an interface between dopamine and poly(L-lactic acid) is responsible for anchoring self-polarization poly(L-lactic acid) chains and promoting crystal nucleation, so that the prepared piezoelectric biomaterial exhibits significantly enhanced piezoelectric performance and excellent service life.

The present invention discloses drug-loaded nanoparticles targeting neuraminidase, as well as a preparation method and application thereof, belonging to the technical field of pharmaceutical preparations. The present invention connects polysialic acid and polylactic acid glycolic acid via an ester bond to obtain drug-loaded nanoparticles with stable structure and performance. The drug-loaded nanoparticles have the function of targeting neuraminidase and have relatively high efficiency in entering cells. Furthermore, antibiotics are dispersed in the drug-loaded nanoparticles, and an inflammatory modulator is adsorbed on the surface of the drug-loaded nanoparticles. The drug-loaded nanoparticles can deliver the antibiotics and the inflammatory modulator to Grasseria suis in pigs, releasing the antibiotics and the inflammatory modulator in the slightly acidic environment of the infected site in the pig, thereby efficiently killing Grasseria suis and reducing inflammatory damage caused by bacterial infection and toxic damage of the antibiotics. Therefore, the present invention has good application prospects in the preparation of drugs for preventing and / or treating Grasseria suis infection.

The present invention relates to a sustained release microsphere and a sustained release preparation comprising a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof. The present invention relates to a sustained release formulation, and more specifically, to a sustained release formulation comprising a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof, the sustained-release microparticles comprise a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof, one kind of low-viscosity polylactic acid-glycolic acid copolymer (PLGA) having an intrinsic viscosity of 0.14 dL / g to 0.24 dL / g, and two or more kinds of high-viscosity polylactic acid-glycolic acid copolymers having an intrinsic viscosity of 0.32 dL / g to 0.60 dL / g, so that the sustained-release microparticles do not have the problems of excessive release and delayed release in the initial stage of a drug. Long-term sustained release can be realized, and the bioavailability is excellent.

The invention relates to the technical field of biomedicine, in particular to siRNA (small interfering ribonucleic acid) for interfering Tc11a gene expression, a core-shell type nano particle as well as a preparation method and application of the core-shell type nano particle. The invention relates to a method for treating type I diabetes mellitus by using core-shell nanoparticles (siTc11a NPs) of a targeted mouse Tc11a gene on an NOD model mouse, and provides a preparation method of the nanoparticles. The preparation method comprises the following steps: mixing siRNA (small interfering ribonucleic acid) interfering with a Tc11a gene with cationic liposome G0-C14 to obtain a complex; mixing the complex with a polylactic acid-glycolic acid copolymer to obtain a core substance; and mixing the core substance with the lipid polymer to obtain the core-shell nanoparticles. The invention provides a treatment strategy for treating the type I diabetes mellitus through targeted Tcl1a gene regulation and control.

The present invention relates to an advanced dressing characterized by a powder of polymeric material based on poly(lactic-co-glycolic) acid, functionalized with dextran, maltodextrin, collagen, citric acid, chitosan, polyphenols, colloidal silver, hyaluronic acid and / or salts thereof, polyethylene glycol and alginate. The present invention further relates to a process for producing the powder and the use of the powder in treating non-necrotic skin wounds.

The invention belongs to the field of bone repair materials, and particularly relates to a multifunctional biological composite scaffold for repairing supercritical bone defects and a preparation method of the multifunctional biological composite scaffold. Medical-grade poly-L-lactic acid (PLLA) is used as an organic phase, nano-hydroxyapatite (n-HA) is used as an inorganic phase, a high-toughness substrate is formed through composite precipitation, PLLA provides flexibility, n-HA (the calcium-phosphorus ratio is 1.67) enhances rigidity, and the two-phase mechanical property of the bionic bone is achieved; on the basis, nano-silver particles and rhizoma drynariae flavone drug-loaded hydrogel are newly added, and through multiple innovations such as nano-silver antibiosis, rhizoma drynariae flavone anti-inflammatory bone promotion, dynamic hydrogel drug sustained release and the like, a composite scaffold system with more comprehensive functions and more complex indications is constructed, the multi-dimensional repair requirement of supercritical bone defects is met, and the application prospect is broad. And the technical complexity and systematicness are obviously improved.

Some embodiments of the present invention provide a fibrous article for medical cosmetology comprising a poly-epsilon-caprolactone base layer and cellosilks distributed within the poly-epsilon-caprolactone base layer wherein the material of the cellosilks comprises polylactic acid, polyglycolic acid, a poly (lactic acid-glycolic acid) copolymer, poly (p-dioxanone), or a combination thereof. Some embodiments of the present disclosure also provide methods of making the fibrous article. Polylactic acid, polyglycolic acid, poly (lactic acid-glycolic acid) copolymer, poly (p-dioxanone) or a combination thereof with better mechanical strength are dispersed in poly-epsilon-caprolactone (poly-epsilon-caprolactone, PCL) in a cellosilk form, so that the mechanical strength of a pure PCL product is improved, the excellent cell affinity of the PCL is reserved, the degradation time interval can be regulated and controlled, and the degradation effect of the PCL product is improved. Therefore, the applicability of the fiber product is improved.

The invention discloses injectable poly-L-lactic acid microsphere composite gel capable of inducing rapid regeneration and instant filling of collagen, which is characterized in that poly-L-lactic acid is used as a raw material, and poly-L-lactic acid microspheres are prepared by adopting an emulsification method; the preparation method comprises the following steps: taking collagen and oxidized polysaccharide as raw materials, carrying out Schiff alkali cross-linking reaction on the collagen and the oxidized polysaccharide to prepare composite gel, and uniformly distributing L-polylactic acid microspheres in the composite gel. The aldehyde group on the oxidized polysaccharide and the amino group on the collagen are subjected to a Schiff base cross-linking reaction to form the injectable gel with a three-dimensional network structure. The cross-linked gel provides mechanical tension to uniformly disperse the PLLA microspheres, so that the microspheres are prevented from settling or agglomerating. The composite gel can also improve the hydrophilicity of the microspheres, so that the redissolution dispersity of the microsphere filler is better, and the microspheres settle more slowly. After being injected subcutaneously, the collagen gel can be instantly filled and induce rapid regeneration of collagen, has no chemical cross-linking agent residue, and reduces the risk of inflammation (such as granuloma) caused by the organism and the like.

The invention discloses a modified polylactic acid fiber and a preparation method thereof. The preparation method comprises the following steps: providing polybasic hydroxyl-terminated D-polylactic acid; the method comprises the following steps: respectively providing betaine-grafted D-polylactic acid and a poly (butylene adipate terephthalate)-epoxy-polyether co-modified organic silicon-D-polylactic acid copolymer by taking the multi-hydroxyl-terminated D-polylactic acid as a main raw material, wherein the poly (butylene adipate terephthalate)-epoxy-polyether co-modified organic silicon-D-polylactic acid copolymer; and carrying out Haake blending and melt spinning on the betaine-grafted D-polylactic acid, a poly (butylene adipate-co-modified organosilicon-D-polylactic acid) copolymer, L-polylactic acid, an antioxidant and an anti-hydrolysis agent, so as to obtain the modified polylactic acid fiber. The preparation method comprises the following steps: carrying out Haake blending and melt spinning on the betaine-grafted D-polylactic acid, poly (butylene adipate-co-modified organosilicon-D-polylactic acid copolymer, L-polylactic acid, the antioxidant and the anti-hydrolysis agent. The modified polylactic acid fiber prepared by the method has the characteristics of easy decontamination, hydrophilicity, high temperature resistance and high toughness, and can effectively avoid water washing shedding, and the comprehensive performance is obviously improved.

The invention discloses a cellulose microcrystal reinforced degradable flame-retardant PLA composite material and a preparation method thereof, and belongs to the field of bio-based functional polymer materials. The composite material is prepared from the following components in parts by weight: 80 to 100 parts of polylactic acid (PLA), 3 to 10 parts of bamboo cellulose microcrystal, 3 to 10 parts of biomass polyphosphate, 1 to 5 parts of GO-g-PLA, 10 to 30 parts of PBAT toughening agent and 0.2 to 1 part of auxiliary agent. The preparation method comprises the following steps: (1) preparing high-crystallinity bamboo cellulose microcrystals by adopting a supercritical CO2 method; (2) preparing a GO-g-PLA interface compatilizer through graft polymerization; (3) synthesizing a biomass polyphosphate flame retardant by taking pentaerythritol and diphenolic acid as raw materials; and (4) melting, blending and extruding the components. Through the synergistic effect of a flame retardant-GO-BCMC three-dimensional network, the material has excellent mechanical properties (the tensile strength is 45-47 MPa, and the impact strength is 10-12 kJ / m), high flame retardance (LOI is 28-29%, UL-94 V-0 level) and environmental friendliness (the 180-day biodegradation rate gt); the composite material can be widely applied to the fields of electronic and electric appliances, automotive trim, medical materials and the like.

The invention provides a method for producing lactic acid through synergistic fermentation of organic solid waste and application, and particularly relates to the technical field of garbage treatment. According to the method for producing lactic acid through synergistic fermentation of the organic solid waste, the organic solid waste comprises raw kitchen waste, sewage plant sludge and polylactic acid waste; the method comprises the following steps: A, preparing the raw kitchen waste into liquid-phase kitchen slurry, adding the sludge of the sewage plant, and uniformly mixing to obtain pre-fermented slurry; b, adding the polylactic acid waste into the pre-fermented slurry, and performing sealed fermentation under an anaerobic condition to obtain fermentation liquor; and finally, separating and purifying the fermentation liquor to obtain the lactic acid. According to the method, cheap and rich organic solid wastes are used as raw materials, so that the raw material cost is reduced, the waste treatment cost is also reduced, the lactic acid production is more economical, feasible, stable and efficient, the production cost of the lactic acid is further reduced, and the development of downstream industries is promoted.

The invention relates to the technical field of surface treatment, in particular to a bio-based degradable cable material and a preparation method thereof. The bio-based degradable cable material is prepared from 55 to 65 parts of matrix resin mixed by poly L-lactic acid and poly-3-hydroxybutyrate-3-hydroxyhexanoate, 4 to 6 parts of dianhydride modified castor oil polyol, 10 to 15 parts of polypentamethylene diamine adipate, 5 to 8 parts of nano reinforcing filler, 6 to 10 parts of bio-based plasticizer, 0.5 to 1.0 part of antioxidant and 8 to 12 parts of environment-friendly flame retardant. A dynamic ester bond cross-linked network formed by the reaction of a dynamic ester bond cross-linking agent dianhydride modified castor oil polyol only undergoes ester bond breakage at a high temperature exceeding a normal working range to release stress, and the temperature returns to normal and can be recombined; the semi-interpenetrating network reinforced phase poly (pentamethylene diamine adipate) and the matrix resin form an interpenetrating structure in a molecular chain interpenetrating manner, a stable heat-resistant skeleton is constructed, high-temperature deformation is effectively inhibited, the overall degradability of the material is ensured by the bio-based structure, and the balance of heat resistance and degradability is realized.

The invention provides an apigenin nanoparticle preparation as well as a preparation method and application thereof. The preparation method comprises the following steps: weighing apigenin, dissolving the apigenin in an acetone solution containing a polylactic acid-glycolic acid copolymer, or dissolving the apigenin in an acetone solution containing the polylactic acid-glycolic acid copolymer and Eudragit S100, and uniformly stirring and mixing at room temperature to obtain a mixed solution; dropwise adding the mixed solution into a polyvinyl alcohol solution, carrying out ultrasonic treatment, and removing the solvent to prepare PANPs or PEANPs. The preparation method is simple, and the prepared PANPs and PEANPs are small in particle size and high in encapsulation efficiency, can effectively penetrate through intestinal epithelial barriers and promote internalization of apigenin into cells, have a good slow release characteristic, can remarkably improve the bioavailability of apigenin, and have a good treatment effect on inflammatory bowel diseases. PANPs has a better treatment effect on ulcerative colitis, and PEANPs has a better treatment effect on diffuse colitis.

The invention relates to an absorbable bone hemostasis and repair stent. The absorbable bone hemostasis and repair stent comprises the following raw materials in parts by weight: 15-60 parts of an excipient, 15-60 parts of a softening agent and 5-70 parts of a bone repair promoting component, the excipient is prepared from a polyoxyethylene-polyoxypropylene copolymer; the softening agent comprises a semi-solid mobile phase polymer; the bone repair promoting component comprises a coating and a core, the coating comprises a polylactic acid-glycolic acid copolymer, zinc stearate and potassium bromide, the core comprises calcium phosphate particles, and the coating wraps the surface of the core. The preparation method comprises the following steps: preparing the bone repair promoting component; and preparing the absorbable bone hemostasis repair stent. The absorbable bone hemostasis and repair stent is high in hemostasis and collapse resistance and has good inflammation regulation and bone repair promoting effects. The absorbable bone hemostasis and repair stent can be used for bone hemostasis and bone repair promotion of any bone injury wound.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

The invention belongs to the technical field of biological medicine, and particularly relates to a CD44 / GSH dual-response eutectic drug delivery system and a preparation method thereof.The CD44 / GSH dual-response eutectic drug delivery system comprises a microneedle array composed of a biodegradable polymer matrix formed by hyaluronic acid (HA) and poly (lactic-co-glycolic acid) (PLGA), and the microneedle array comprises a plurality of microneedles; a microneedle comprising a pharmaceutical formulation of a resveratrol-berberine co-crystal integrated into the polymer matrix; wherein the polymer matrix comprises a disulfide bond that is a glutathione (GSH) responsive switch; wherein the hyaluronic acid is capable of specifically targeting a CD44 receptor; wherein the disulfide bond can be cleaved under the condition that the concentration of glutathione in a target tissue is increased, thereby releasing the resveratrol-berberine eutectic pharmaceutical formulation; and wherein the microneedle array is configured to percutaneously deliver the resveratrol-berberine co-crystal pharmaceutical formulation to the target tissue.

The invention relates to the field of pesticide materials, and provides an insecticidal composition and a preparation method thereof, and the insecticidal composition comprises pyrethrin-loaded hydrogel powder, copolymer coated neem oil microspheres, lecithin, tea saponin, fructus cnidii, sophocarpidine, gallic acid, chitosan, piperine, deionized water and a citric acid buffer agent. The pyrethrin-loaded hydrogel powder is prepared by taking sodium alginate, gelatin and silanized cellulose as matrixes, forming hydrogel through Cacrosslinking, and performing freeze drying and grinding; the copolymer coated neem oil microspheres are prepared by adopting a polylactic acid-glycolic acid copolymer as a carrier through water-in-oil emulsification, high-speed homogenization, solvent volatilization, centrifugal purification and freeze drying. The preparation method comprises the steps of dissolving, stirring, homogenizing, emulsifying, microsphere curing, drying and grinding. Through a hydrogel and microsphere sustained-release system, the stability and persistence of insecticidal active ingredients are improved, the environmental protection problem and long-acting release are solved, and the hydrogel microsphere has wide agricultural application value.

The invention relates to the technical field of drug delivery, and discloses a multilayer drug-loaded microsphere for intraocular sustained-release therapy and a preparation process thereof.The multilayer drug-loaded microsphere comprises a core layer, a middle layer and a shell layer, the core layer is composed of a polylactic acid-glycolic acid copolymer (PLGA) and a first hydrophobic drug, the middle layer is formed by wrapping the core layer with carboxymethyl chitosan, and the shell layer is composed of a first hydrophobic drug and a second hydrophobic drug. The first hydrophobic drug comprises a first therapeutic drug, the middle layer comprises a second therapeutic drug, the shell layer is composed of a polylactic acid-caprolactone copolymer PLCL and a third hydrophilic drug, and the first hydrophobic drug, the second therapeutic drug and the third hydrophilic drug are different from one another. Through the layered design of the core layer, the middle layer and the shell layer and in combination with differential degradation rates of PLGA, carboxymethyl chitosan and PLCL materials, gradient release of hydrophobic and hydrophilic drugs is achieved, a drug release curve is matched with the pathological stage of intraocular diseases, macular degeneration rapidly inhibits vascular leakage in the early stage and continuously resists inflammation in the later stage, and the effect of treating macular degeneration is achieved. And the layered slow-release synergistic treatment effect is verified.