PLA/PLGA shell-core microballoons prepared by oil in water-solid in oil method, and preparation method thereof
A solid-in-oil and oil-in-water technology, which is applied in the preparation of shell-core microspheres and its preparation, can solve the problems of incomplete release and inability to overcome the encapsulation rate, and achieve good redispersibility
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Embodiment 1
[0030] Example 1: Preparation of PLA / PLGA shell-core microspheres loaded with small molecule drug particles
[0031] (1) Prepare small molecule drugs or small molecule drugs and pharmaceutical excipients into drug granules;
[0032] In this embodiment, the small molecule drugs used are tumor chemotherapy drugs (tumor chemotherapy drugs are selected from: doxorubicin, cyclophosphamide, dactinomycin, bleomycin, daunorubicin, doxorubicin, epirubicin Mitomycin, Mitomycin, Methotrexate, Fluorouracil, Carboplatin, Carmustine (BCNU), Semustine, Cisplatin, Etoposide, Camptothecin and its derivatives, Cholesterol , paclitaxel and its derivatives, docetaxel and its derivatives, vinblastine, vincristine, tamoxifen, etoposide, piposulfan, cyclophosphamide, or flutamide and its derivatives; sustained release Microspheres can be loaded with one or more of the above drugs;) or antibiotics (antibiotics are selected from cyclosporine, levofloxacin, ofloxacin, or epinastine hydrochloride; slow...
Embodiment 2
[0047] Example 2: Preparation of PLA / PLGA shell-core microspheres loaded with biomacromolecular drug particles
[0048] (1) Prepare biomacromolecular drugs or biomacromolecular drugs and pharmaceutical excipients into drug granules;
[0049] In this example, the biomacromolecular drugs used are erythropoietin (EPO), recombinant human granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), vaccines, Interferon (INF), growth hormone (GH), insulin (Insulin), epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor (TGF-β), insulin-like growth factor (IGF), Vascular endothelial growth factor (VEGF), platelet growth factor (PDGF), endothelial growth factor (ECGF), nerve growth factor (NGF), bone-derived growth factor (BDGF), bone morphogenic protein (BMP), tissue polypeptide antigen ( TPA), antibody (antibody), coagulation factor VIII (VIII), genetic factor IX, antisense nucleotide (anti-RNA), small...
Embodiment 3
[0062] Embodiment three: the preparation of loading interferon (IFN) drug particle PLA / PLGA shell-core microsphere
[0063] (1) Prepare interferon and pharmaceutical excipients into pharmaceutical granules; the specific ratio is as follows:
[0064] drug
medical supplements
Drug accounted for particle weight
volume percentage drug
medical supplements
Drug accounted for particle weight
80%, 50%, 25%
%, 10% or 5%
IFN
Cyclodextrin and sucrose (9:1),
(7:1), (6:1), (5:1)
or (3:1) 100%, 80%, 50%
%, 25% or 10%
IFN
Trehalose (9:1:1)
80%, 50%, 25%
%, 10% or 5%
IFN
polyethylene glycol, chitosan and
Sorbitol (8:1:1) or
(5:1:1) 100%, 80%, 50%
%, 25% or 10%
IFN
Glucan and Seaweed
Sugar (9:1)
80%, 50%, 25%
%, 10% or 5%
IFN
Dew...
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