100results about How to "Smooth and rounded surface" patented technology

The invention belongs to the technical field of organic materials, relating to a preparation method for a conductive polymer sheathing material. The conductive polymer sheathing material comprises the following components in percent by mass: 60-30 percent of thermoplastic polymer resin, 25-30 percent of nanometer conductive carbon black, 5-14 percent of conductive carbon fiber or conductive agent, 10-18 percent of flexibilizer and 0.5-1.5 percent of processing aid and 1-3 percent of dispersing agent. The preparation method comprises the steps of: mixing and stirring well the raw materials of all the components and forming a product by melting, extruding, cooling, granulating, drying and packaging with a double-screw extruder; or adding a mixture consisting of the raw materials of all the components into an internal mixer for complete kneading, mixing and dispersing, then conducting mixing, rolling, laminating and crushing with a double-roller open mill and forming the product by melting, extruding, cooling, granulating, drying and packaging with a single-screw extruder. The preparation method has a simple process, and the conductive polymer sheathing material has the advantages of good electrical properties, low cost and production environment protection performance.

The invention discloses medicament carrying polymer nano particles and a preparation method thereof in the technical field of pharmacy. The medicament carrying polymer nano particles contain medicaments and polylactic acid-methoxy polyethylene glycol (PLA-mPEG) or poly (lactic-co-glycolic acid)-methoxy polyethylene glycol (PLGA-mPEG). The molecular weight of the block polylactic acid (PLA) or the poly (lactic-co-glycolic acid) (PLGA) is 10,000 to 60,000, the molecular weight of the block methoxy polyethylene glycol (mPEG) is 2,000 to 5,000, and the block ratio of the PLA or the PLGA to the mPEG is (60:40)-(90:10). The preparation method of the nano particles avoids the defects of low medicament nano particle entrapment rate and serious burst release caused by using the conventional surfactant, complex removing steps and the like; and the medicament carrying polymer nano particles with high quality are synthesized by simplified processes and with relatively low cost.

The invention provides a salidroside segmented copolymer lipid nanoparticle preparation for intravenous injection and a preparation method of the nanoparticle preparation, as well as application of the preparation in preparing anti-cancer medicaments. The preparation comprises salidroside, segmented copolymer, lipid and surfactant.

The invention discloses a method for manufacturing a small-pitch aluminum stranded wire. A lay plate with a proper size and a distance between the wire distributing plate and an inlet of a closing die are selected on a fork wire-stranding machine set; an angle between an aluminum wire which is led out of a wire hole on the external periphery of the lay plate and then enters the inlet of the closing die and a core wire which is led out of an axle tube and then enters the inlet of the closing die is between 45 and 63 degrees when the aluminum stranded wire on the outermost layer is stranded and is between 35 and 50 degrees when the aluminum stranded wires on the other layers are stranded; and the obtained lay ratio value of the outermost layer is between 3.5 and 4.5 and the lay ratio value of the other layers is between 6.5 and 8.5. The aluminum wire which is subjected to heat treatment is taken as a raw material; the ratio of a pitch of the cylindrical helix-shaped aluminum wire in each layer of the aluminum stranded wire to the diameter of a cylindrical surface on which the cylindrical helix-shaped aluminum wire on the layer is arranged is relatively small; the aluminum stranded wire is easily bent; the allowable bending radius is relatively small; and after being bent into small bends, the aluminum stranded wire does not bridle wire, deform or get out of a sleeve, and has a smooth, round and flat surface and a stable structure and is suitable for serving as the aluminum stranded wire for connecting electric contacts of power distribution equipment in a high-voltage substation and a high-voltage converter station.

The invention provides a traditional Chinese medicine granular preparation with angelica extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g/ml to 1.3 g/ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

The invention provides a traditional Chinese medicine granular preparation containing grass-leaved sweetflag extractive and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by traditional Chinese medicine extractive and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g/ml. The spheroidized particles of the invention have low single dose, are convenient in use, can be served as intermediate products of capsules, and also can be used for developing traditional Chinese medicine controlled release preparation.

The invention relates to a traditional Chinese medicine pellet which is prepared from traditional Chinese medicine extractives or traditional Chinese medicine extracts and a base pellet according to the weight ratio of (1:5)-(5:1); and the traditional Chinese medicine pellet has the bulk density of 0.6-1.3g/ml, the specific surface area of 0.005-0.05m<2>/g and the particle size of 0.5-1.8mm. The invention also provides a preparation method of the pellet, so that the problems that traditional Chinese medicines or vegetable drugs easily absorb moisture and are unstable are solved; and the preparation method is simple, feasible and suitable for industrial production.

The invention provides a traditional Chinese medicine granular preparation with notoginseng extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g/ml to 1.3 g/ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

The invention provides a traditional Chinese medicine granular preparation with ginkgo biloba extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using the ginkgo biloba extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g/ml to 1.3 g/ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

The invention discloses sorghum and honeysuckle dietary rice. The sorghum and honeysuckle dietary rice is prepared from the following raw materials in parts by weight: 60-70 parts of sorghum, 10-14 parts of walnut kernels, 100-120 parts of brown rice, 30-40 parts of corn cobs, 10-12 parts of honeysuckles, 6-7 parts of lemon grass, 20-30 parts of snow pears, 10-15 parts of sweet oranges, 3-4 parts of mint leaves, 1-2 parts of angelica dahurica, 2-3 parts of radix scutellariae, 1-2 parts of tree peony bark, 2-3 parts of greenish lily seeds, 7-9 parts of cocoa powder, and an appropriate amount of soybean milk. According to the sorghum and honeysuckle dietary rice disclosed by the invention, the brown rice is used as the main material, and the nutrients raw materials, such as the sorghum and the honeysuckles, are added to be reorganized and processed to obtain the dietary rice. The sorghum and honeysuckle dietary rice is sparkling, crystal-clear and bright in appearance, smooth, mellow and full in surfaces, high in transparency, compact in structure, long in shelf time, short in cooking time, good in appearance of rice after being cooked, free from pastiness or deformation, light in fragrance of flowers, tenacious in mouth feel, and moderate in soft and hard degrees. After being eaten for a long term, the sorghum and honeysuckle dietary rice has the efficacies of nourishing the kidney, warming the lung, relieving rigidity of muscles and activating collaterals, regulating the function of the stomach, ventilating, loosening bowel to relieve constipation and the like.

The invention discloses a chlorinated polyethylene sheath formula applied to imported extrusion equipment. The active ingredients of the chlorinated polyethylene sheath formula are prepared from the following raw materials in parts by weight: 70-80 parts of chlorinated polyethylene 3000, 20-30 parts of chlorinated polyethylene 7130, 3-5 parts of DCP, 1-2 parts of TAIC, 1-2 parts of TMPTMA, 0.5-1 part of an antiageing agent TMQ, 1 part of a flowing dispersing auxiliary Aflex 16, 6-10 parts of magnesium oxide, 1-2 parts of lead stearate, 1-2 parts of dibasic lead phthalate, 40-60 parts of highly reinforced modified argil Supfil 505, 60-80 parts of talc powder, 3-5 parts of carbon black, 10-15 parts of chlorinated paroline and 6-8 parts of DOP. The chlorinated polyethylene sheath formula applied to imported extrusion equipment disclosed by the invention has high strength, high flame retardance, high tear resistance and excellent extruding property.

The invention provides a traditional Chinese medicine granular preparation with ageratum extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g/ml to 1.3 g/ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

The invention provides an SN-38-PLGA sustained release microsphere for intratumoral injection and a preparation method and application thereof. SN-38 is used as a model drug, PLGA is used as a carriermaterial, the SN-38-PLGA sustained release microsphere capable of being available for intratumoral injection dose is successfully built by adopting an emulsification-solvent evaporation method, and the SN-38-PLGA sustained release microsphere has the advantages of smooth and rounded surface, moderate particle size and high encapsulation efficiency and drug-loading capacity and the like; and meanwhile, the SN-38-PLGA sustained release microsphere for the intratumoral injection can enable the SN-38 to maintain effective high concentration for a long time in a tumor area, inactivation of the SN-38 drug is effectively avoided, and thus good practical application value is achieved.

The invention provides a traditional Chinese medicine granular preparation with total salvianolic acid and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using the total salvianolic acid and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g/ml to 1.3 g/ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

The invention discloses a preparation method of sustained-release microspheres and hemopoietin sustained-release microspheres prepared thereby. The preparation method adopts a hydrophilic-oil-in-water, oil-in-hydrophilic-oil and solid-in-oil technique, which comprises the following steps: A, adding coated solid particles in organic solution of a sustained/controlled-release material, and uniformly mixing to form mixed suspension; B, adding the mixed suspension obtained by the step A into hydrophilic organic solution which does not dissolve the sustained/controlled-release material used in the step A, and stirring to form microspheres; and C, dispersing the microspheres formed by the step B into a water phase for solidification. The preparation method can effectively overcome the drawbacks of low coating rate, serious sudden release, incomplete release and the like. The hemopoietin sustained-release microspheres and hemopoietin sustained-release microspheres have smooth surface and are round, the particles are regular and not adhered, and the freeze-dried powder of the hemopoietin is white, fine, loose and free from collapse and adhesion and has high redispersibility. The hemopoietin sustained-release microspheres can be used for treating various related diseases to be treated for a long time with hemopoietin.

The invention provides a high-temperature and low-temperature resisting ferrite material for a cold heading bolt and a production technology of the high-temperature and low-temperature resisting ferrite material. The high-temperature and low-temperature resisting ferrite material comprises following components including, by mass percent, 0.17 wt%-0.25 wt% of C, 0.40 wt%-0.80 wt% of Mn, larger than0 and smaller than or equal to 0.4 wt% of Si, larger than 0 and smaller than or equal to 0.025 wt% of P, larger than 0 and smaller than or equal to 0.025 wt% of S, 1.20 wt%-1.50 wt% of Cr, larger than 0 and smaller than or equal to 0.60 wt% of Ni, 0.55 wt%-0.80 wt% of Mo, larger than 0 and smaller than or equal to 0.030 wt% of Al, larger than 0 and smaller than or equal to 0.030 wt% of V and thebalance Fe and inevitable impurities. The ferrite material has high plasticity indexes, elongation rate and percentage reduction of area, during cold plastic deformation, the material deformation resistance is small, the machining hardening rate is low, the material yield ratio is low, and hardness is proper.

The invention relates to a benserazide sustained-release microspherical composition, which comprises the following components by weight percent: 40%-99% of a degradable hydrophobic polymer and 1%-60% of benserazide. The invention also provides a preparation method of the benserazide sustained-release microspherical composition. The invention can overcome the instability of benserazide during the storage process and improve the pharmaceutical therapeutic effect on patients. The method for preparing the microspherical composition can avoid the defects of low entrapment rate of the conventional W/O and W/O/W, and environmental pollution of S/O/O caused by serious burst release. In the invention, the grain diameter of the microspherical composition prepared by the method can be controlled according to different demands without environmental pollution, and the influence on the therapeutic effect of benserazide can be prevented. The surfaces of the obtained granules are smooth and rounded, the granules are regular without adhesion, the grain diameter can be regulated and controlled from 1mum to 5mum as required, and freeze-drying powder of the granules is white, exquisite and loose, is not collapsed and adhered, and has good redispersibility.

The invention provides high-temperature-resistant ferritic stainless steel for a cold heading fastener nut and a production process thereof. The high-temperature-resistant ferritic stainless steel iscomposed of the following components including, by weight, larger than 0 and smaller than or equal to 0.06% of C, larger than 0 and smaller than or equal to 1.0% of Mn, larger than 0 and smaller thanor equal to 1.0% of Si, larger than 0 and smaller than or equal to 0.045% of P, larger than 0 and smaller than or equal to 0.04% of S, 10.5%-11.75% of Cr, larger than 0 and smaller than or equal to 0.5% of Ni, 0.25%-0.75% of Nb and 84.89%-86.61% of Fe. According to the high-temperature-resistant ferritic stainless steel, a product cannot deform and can be used for cold heading materials through heat treatment hardening under continuous working of a 500 DEG C high temperature area, and the high plasticity index, elongation and the area reduction rate are achieved. During cold plastic deformation, the deformation resistance of the materials is small, the work hardening rate is low, and the yield ratio of the materials is small, and the hardness is appropriate.