The invention provides a small-space LED display module and a manufacturing method of the small-space LED display module. The small-space LED display module comprises a mounting base plate, an LED lamp panel and protective colloid, wherein the LED lamp panel comprises a circuit board and a plurality of LEDs arranged on the circuit board at intervals, the circuit board is arranged on the surface ofone side of the mounting base plate, and the LEDs are arranged on the surface of one side, far away from the mounting base plate, of the circuit board; and the protective colloid is arranged in gapsamong the LEDs, and the surface of one side, far away from the circuit board, of the protective colloid is level with the surfaces of one sides, far away from the circuit board, of the LEDs. The protective colloid can play a very good protection role on the LEDs, so that the problems of knocking on the LEDs and the breakage of the LEDs due to the excessive humidity are effectively solved. Meanwhile, the surface of one side, far away from the circuit board, of the protective colloid is level with the surfaces of one sides, far away from the circuit board, of the LEDs, so that the cleaning for the surface of the LED lamp panel is easy. In addition, the processing mode of the protective colloid is simple, the processing is convenient and reliable, and the method is satiable for the industriallarge-scale application.