Collagen device and method of preparing the same

Abstract

A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in part-of utility application U.S. Ser. No. 10 / 955,835, filed Sep. 30, 2004, entitled COLLAGEN AND METHOD OF PREPARING THE SAME which claims priority to previously filed provisional applications U.S. Ser. No. 60 / 542,968, filed Feb. 9, 2004, entitled COLLAGEN AND METHOD OF PREPARING THE SAME, and Ser. No. 60 / 565,747, filed Apr. 27, 2004, entitled COLLAGEN DEVICE AND METHOD OF PREPARING SAME, all of which are hereby incorporated by reference in their entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] Not Applicable. FIELD OF THE INVENTION [0003] The present invention relates to a collagen device and a method of preparing the same. More specifically, the present invention relates to a method for preparing a collagen device for use as an implant to replace, reinforce or strengthen bodily tissue, an adhesion barrier, or for use as a short-term body contact for moisture retention, hemostasis o...

AI Technical Summary

Benefits of technology

[0006] The present invention is directed to a collagen device that has a plurality of pores wherein a majority of the pores have a diameter of less than 10 μm. Surprisingly, the collagen device made in accordance with the present invention has good handling properties, as the collagen device is sufficiently flexible to conform to irregular-shaped surfaces but stiff enough that it does not curl or adhere to itself, instruments or the practitioner's gloved hands when wet. In addition, the collagen device in accordance with the present invention has very good strength properties, such as tensile strength, making it very easy to handle for the physician. Further, the collagen device in accordance with the present invention can be made the same shape or size as conventional collagen devices, such as currently available collagen dural grafts, while still providing the surgeon with a device that has superior strength and handling properties.

[0008] In one embodiment, a dural graft includes a collagen layer having substantially planar opposed surfaces and at least one reinforcement layer disposed on at least one planar surface of the collagen layer. Both the collagen layer and the reinforcement layer are configured to substantially conform to a curvature of a tissue. The reinforcement layer has a suture retention strength that is greater than a suture retention strength of the collagen layer. The present dural graft, therefore, is configured for use as both an onlay graft and a suturable graft. Because the dural graft substantially conforms to a curved tissue surface, the dural graft minimizes the presence of gaps between the dural graft and the tissue. Additionally, the dural graft can withstand a suture pull out stress either while the dural graft is sutured to a tissue or after the dural graft has been sutured to the tissue.

Problems solved by technology

When the integrity of a person's meningeal membranes is intentionally or accidentally compromised, serious consequences may ensue, unless the membranes can be repaired.

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