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Adhesive composition comprising tannin, polyethylene glycol, and water, lower alcohol or mixture thereof

A polyethylene glycol and synthetic technology, applied in the direction of polyether adhesives, adhesive types, natural resin adhesives, etc., can solve the problems of needing a thermosetting curing agent and difficult to maintain adhesion

Active Publication Date: 2013-12-18
KOREA ADVANCED INST OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also water soluble, making it difficult to maintain adhesion in aqueous environments
[0006] Tannin adhesive (tannin adhesive) has attracted everyone's attention as a non-toxic natural adhesive (adhesive), but due to its water solubility and the need for a thermosetting curing agent, there are limitations in its use

Method used

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  • Adhesive composition comprising tannin, polyethylene glycol, and water, lower alcohol or mixture thereof
  • Adhesive composition comprising tannin, polyethylene glycol, and water, lower alcohol or mixture thereof
  • Adhesive composition comprising tannin, polyethylene glycol, and water, lower alcohol or mixture thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0185] Manufacture of adhesives including tannin, polyethylene glycol (PEG) and water (adhesive)

[0186] Tannic acid (tannic acid, chemical formula 1) was dissolved in 1x PBS (Phosphate-buffered saline) buffer solution (buffer: pH 8.5) at a concentration of 1 g / mL. Finally, the linear or multi-branched ( Multi branched) polyethylene glycol (Polyethylene Glycol, PEG) was dissolved in 1x PBS (Phosphate-buffered saline) buffer solution (buffer: pH 8.5) at a concentration of 1 g / mL.

[0187] chemical formula 1

[0188]

[0189] Mix tannin with PEG, mPEG-SH, mPEG-AM, mPEG-SS, PEG-AM, 4-arm-PEG-AM, 4-arm-PEG-SS, and 6-arm-PEG-AM. After standing for about ten minutes, a brown adhesive (adhesive) precipitated below, and the upper layer was a transparent liquid. After decanting the supernatant, the lower brown adhesive was used. figure 1 Indicates extraction of the underlying brown adhesive.

[0190] The adhesive composition of the present invention was produced by using ...

Embodiment 2

[0194] Determination of Adhesion

[0195] Using a biopsy punch (Biopsy punch, Miltex REF33-36), the porcine skin tissue was cut out with a diameter of 6 mm. Between the two porcine skin tissues, about 3 g of the adhesive (adhesive) produced in the above-mentioned Example 1 was evenly applied, and the instant adhesive was bonded on the back side, and sticks for measuring the adhesive force were respectively pasted. After applying a force of 20 N to the sample for 1 minute using a universal testing machine (Universal Testing Machine, INSTRON 5583), a tensile force was applied at a speed of 1 mm / min to measure the adhesive force. For adhesives (adhesives) manufactured using different polyethylene glycols (Polyethylene Glycol, PEG), three or more consecutive samples were measured, and the average adhesive force and the maximum adhesive force were obtained.

[0196] results, such as Figure 4 , Figure 5 As shown, when the solvent is water, the adhesion of 4-arm-PEG-AM (10kDa)...

Embodiment 3

[0200] Determination of the relationship between bonding times and bonding force and duration

[0201] 4-arm-PEG-OH (10 kDa) and 4-arm-PEG-AM (10 kDa) adhesives were produced in the same manner as in Example 1. In the same manner as in Example 2, porcine skin tissue was cut out with a diameter of 6 mm. Between the two porcine skin tissues, about 3 g of the adhesive (adhesive) prepared above was evenly applied, and the instant adhesive was adhered on the back side, and sticks for measuring the adhesive force were respectively pasted. After a universal testing machine (Universal Testing Machine, INSTRON5583) was used to apply a force of 20 N to the sample for 1 minute, the tensile force was applied at a speed of 10 mm / min to measure the adhesive force. This process was repeated thereafter, and changes in the adhesive (adhesive) associated with the number of times were detected. 4-arm-PEG-OH (10kDa) tested a sample continuously for 5 hours and 82 times. 4-arm-PEG-AM (10kDa) ...

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Abstract

The present invention relates to an adhesive composition comprising tannin, polyethylene glycol, and water, wherein the adhesive composition has little toxicity, can be adhered even without a thermosetting curing agent which is different from conventional tannin adhesives, and is poorly soluble in water to be resistant against moisture, and thus can be used as a medical adhesive. The adhesive of the present invention has little toxicity, can be adhered even without a thermosetting curing agent which is different from conventional tannin adhesives, and is poorly soluble in water to be resistant against moisture. Therefore, the adhesive of the present invention can be used as a medical adhesive, an extended release drug delivery system, an adhesion barrier, an agent for preventing the adsorption of cells and proteins, and a medical hemostatic which can be used in various wet environments.

Description

technical field [0001] This application claims priority from Korean Patent Application No. 10-2010-0090232 filed on September 14, 2010, and the entire specification of said patent is a reference document of the present invention. [0002] The present invention relates to the adhesive composition that comprises tannin (tannin), polyethylene glycol (Polyethylene Glycol, PEG) and water, lower alcohol (low alcohols) or their mixture, relate in particular to a nontoxic, water-resistant , Adhesive compositions that can be used as biological adhesives without heating, and medical adhesives including this, controlled released drug delivery agent (controlled released drug delivery agent), anti-adhesive agent (Anti-adhesive agent), cell protein anti-adsorption agent, medical hemostatic agent (hemostatic). Background technique [0003] Adhesive (adhesive) is a substance used to bond the surfaces of two objects. According to the definition of the International Organization for Standard...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J193/00C09J171/02C09J11/00A61K9/00
CPCA61K9/0024A61K9/7007A61L24/043A61L24/046C09J171/02C08L71/02
Inventor 李海臣李汶修洪先基金锦莲
Owner KOREA ADVANCED INST OF SCI & TECH
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