Preparation method of material for abdominal wall defect intraperitoneal repair, and obtained material thereof

An intraperitoneal and abdominal wall technology, applied in the field of medical devices and their preparation, can solve the problems of dependence on imports, high price, unfavorable wide application, etc., and achieves good anti-adhesion and antibacterial properties, good biocompatibility, and good mechanical properties. Effect

Inactive Publication Date: 2015-08-12
王辉 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the traditional polypropylene patch cannot be applied to the intraperitoneal repair of abdominal wall defects; moreover, the existing intraperitoneal repair materials still have relatively many complications such as infection and recurrence, and rely on imports, which are expensive and unfavorable Wide application in clinical

Method used

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  • Preparation method of material for abdominal wall defect intraperitoneal repair, and obtained material thereof
  • Preparation method of material for abdominal wall defect intraperitoneal repair, and obtained material thereof
  • Preparation method of material for abdominal wall defect intraperitoneal repair, and obtained material thereof

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Effect test

Embodiment 1

[0042] The 0.3810g bacterial cellulose obtained by the cultivation of Acetobacter xylinum was added to 19mmol / L cerium ammonium nitrate solution and activated at room temperature for 3h, and after elution and drying, 50ml of dimethylaminoethyl methacrylate with a mass fraction of 9% was added The solution was grafted, and 5ml of 45% nitric acid aqueous solution and 1g of copper powder were added, and then reacted under nitrogen atmosphere for 6h. Take out the bacterial cellulose and wash it with water, then add it to 50ml brominated n-butane and acetone solution (volume ratio is 1:3.5), take it out after shaking and reacting at 40°C for 8h, then add it to 50ml brominated dodecane and acetone solution (1:4 by volume), continue to react at 40°C for 8h, wash with 95% ethanol and dry. A certain amount of bacterial cellulose obtained above was activated by a 10% ethylenediamine solution for 2 hours by mass fraction, and then dissolved in a mixed solution of 73.3ml lithium chloride ...

Embodiment 2

[0048] Add 0.4 g of bacterial cellulose obtained by culturing Acetobacter xylinum into 20 mmol / L cerium ammonium nitrate solution for activation at room temperature for 2 h, and add 55 ml of dimethylaminoethyl methacrylate with a mass fraction of 10% after eluting and drying The solution was grafted, and 5ml of 45% nitric acid aqueous solution and 1g of copper powder were added, and then reacted under nitrogen atmosphere for 6h. Take out the bacterial cellulose and wash it with water, then add it to 50ml brominated n-butane and acetone solution (volume ratio is 1:4), take it out after shaking and reacting at 45°C for 10h, then add it to 50ml brominated dodecane and acetone solution (1:4 by volume), continue to react at 45°C for 10h, wash with 95% ethanol and dry. A certain amount of bacterial cellulose obtained above was activated by a mass fraction of 10% ethylenediamine solution for 2 h, and then dissolved in a mixed solution of 39 ml of lithium chloride and N-dimethylacetam...

Embodiment 3

[0051] Add 0.8 g of bacterial cellulose obtained by Acetobacter xylinum culture into 21 mmol / L cerium ammonium nitrate solution for activation at room temperature for 2 h, elute and dry, then add 80 ml of dimethylaminoethyl methacrylate with a mass fraction of 15% The solution was grafted, and 6ml of 45% nitric acid aqueous solution and 1g of copper powder were added, and then reacted under nitrogen atmosphere for 8h. Take out the bacterial cellulose and wash it with water, then add it to 80ml brominated n-butane and acetone solution (volume ratio is 1:4), take it out after shaking and reacting at 45°C for 8h, then add it to 80ml brominated dodecane and acetone solution (1:4 by volume), continue to react at 45°C for 8h, wash with 95% ethanol and dry. A certain amount of bacterial cellulose obtained above was activated with a mass fraction of 10% ethylenediamine solution for 2 hours, and then dissolved in a mixed solution of 39ml lithium chloride and N-dimethylacetamide (mass r...

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Abstract

The present invention discloses a preparation method of a material for abdominal wall defect intraperitoneal repair, and the obtained material thereof. The preparation method comprises: 1, preparing a quaternized bacterial cellulose solution; 2, carrying out polydopamine modification on a polypropylene mesh sheet; and 3, coating the quaternized bacterial cellulose solution on the obtained polypropylene mesh sheet. The present invention further provides the material used for the abdominal wall defect intraperitoneal repair and obtained through the process. The obtained material of the present invention has characteristics of good mechanical property, good biocompatibility, good adhesion resistance and good antibacterial property.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a preparation method of a material for intraperitoneal repair of abdominal wall defect and the material obtained by the preparation method for intraperitoneal repair of abdominal wall defect. Background technique [0002] At present, the traditional tension-free abdominal wall defect repair material polypropylene (PP) mesh is only used for extraperitoneal repair, and there is no safety problem of abdominal viscera. With the advancement of surgical technology, it cannot meet the needs of laparoscopic surgery and intraperitoneal repair. If it is used for intraperitoneal repair, a series of complications will occur, including intestinal fistula, intestinal obstruction, sinus formation, infection and obvious pain. Therefore, the traditional polypropylene patch cannot be applied to the intraperitoneal repair of abdominal wall defects; moreover, the exist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/50A61L27/54
Inventor 王辉胡民辉黄榕康杨科力曾杨吴丁财赵洁赵日升汪建平
Owner 王辉
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