8 results about "Organ preservation solution" patented technology

The application discloses a kind of pharmaceutical composition, organ preservation fluid and its application, the pharmaceutical composition includes seduxian and edaravone.The mass ratio of seduxian and edaravone is 1:0.0001-10000.The cell protection effect of the pharmaceutical composition of the application is good, seduxian and edaravone show synergistic effect, help to obtain excellent curative effect, and reduce drug dosage, help to improve clinical drug safety.

Serum albumin is an important molecule in human and animal blood. It provides oncotic pressure and acts as a transportation agent, delivering nutrients from the blood to the tissue and removing waste products from the tissue to the blood. This invention describes an organ preservation and / or perfusion solution which comprises acetylated serum albumin, as well as method of making and using such a solution, and uses of acetylated serum albumin itself. The acetylated serum albumin utilised in the present invention can protect the vascular endothelium during perfusion of an isolated organ or tissue.

A pharmaceutical composition, an organ preservation solution, and their applications are disclosed, wherein the pharmaceutical composition comprises cedutinib and edaravone. The mass ratio of cedutinib to edaravone is 1:0.0001-10000. The pharmaceutical composition of the present invention exhibits good cell protection effects, and cedutinib and edaravone demonstrate a synergistic effect, contributing to excellent therapeutic efficacy, reducing drug dosage, and improving clinical drug safety.

The invention belongs to the technical field of medical equipment, and particularly discloses a reversible electroporation combined medical kit for organ transplantation and transfer and application of the reversible electroporation combined medical kit. According to the medical kit for organ transplantation, a novel electric pulse device is additionally designed on the basis of original design, a large amount of emergency response generated after organ transplantation can be remarkably reduced, and the survival rate of organs is increased. The novel electric pulse device is designed to be attached to the inner wall of the box body, the designed electric pulse electrode plate is attached to the buffer pad, the buffer pad is made of an insulating non-toxic heat preservation material, and organ preservation liquid is contained in the organ preservation bag. According to the medical kit for organ transplantation, the additional electrodes can be used for applying electric pulses to organs in the organ storage bag, medicine in the organ storage liquid is promoted to enter the organs, meanwhile, the optimal applied pulse intensity is confirmed in combination with cell experiments, the potential distribution condition is simulated and confirmed in combination with simulation software, and emergency reaction generated after perfusion can be reduced; therefore, normal organ functions are ensured, and the success rate of transplantation is improved.

The utility model discloses an automatic organ preserving fluid adding and transferring device, which relates to the technical field of living tissue transportation and comprises a storage cylinder, a cylinder cover is movably mounted on the outer side of the storage cylinder close to the upper side, and the upper side of the cylinder cover is fixedly connected with a fluid storage bin. Handles are fixedly connected to the positions, close to the upper side, of the left side and the right side of the storage barrel, the inner side of the storage barrel is movably sleeved with a placement mechanism, and a liquid injection mechanism is rotationally connected to the upper side of the placement mechanism. According to the automatic organ preserving fluid adding and transferring device, through pulling of the tension spring, the pressing plate is used for fastening the tank cover, the injection pipe is pushed through the electric push rod, the pressing net is made to move up and down, the height of the pressing net can be adjusted, small biological tissue is prevented from shaking at will when transported in the inner tank, and the working efficiency is improved. Meanwhile, when the whole bottom plate is placed, the tank cover is still in a fixed state, and the living tissue is prevented from spilling out.

The invention discloses a pharmaceutical composition for targeted activation of FSP1 and application of the pharmaceutical composition. The pharmaceutical composition comprises a medicine capable of activating ferroptosis inhibitory protein 1 and a reduced coenzyme I capable of enhancing the ferroptosis inhibitory protein 1 activation effect of the medicine. The medicine capable of activating the ferroptosis inhibition protein 1 comprises a second-generation sulfonylurea medicine; and the second generation sulfonylurea medicine is glimepiride or glibenclamide. The glimepiride, glibenclamide and other second-generation sulfonylurea drugs are combined with NADH, and the resistance of cells to ferroptosis can be remarkably improved by activating or improving the activity of FSP1, so that cell death after ischemia-reperfusion injury is inhibited; meanwhile, the invention provides new application of the glimepiride, the glibenclamide and other hypoglycemic drugs, the adaptation diseases of the glimepiride, the glibenclamide and other hypoglycemic drugs are expanded, and the glimepiride, the glibenclamide and other hypoglycemic drugs are combined with the NADH, so that the glimepiride, the glibenclamide and other hypoglycemic drugs can be used for treating ischemia reperfusion injury related diseases and organ preservation liquid to improve the protection effect on organs.

The application discloses a kind of for reducing transplantation fat liver ischemia-reperfusion injury preservation solution, belong to biomedical technical field.The application provides the application of fibroblast growth factor 21 in the preparation of drug or liver transplantation organ preservation solution for preventing and treating ischemia-reperfusion induced liver injury.By exogenous supplement fibroblast growth factor 21, ischemia-reperfusion induced hepatocyte injury can be effectively improved;Especially for fatty degeneration transplantation liver, not only can inhibit ischemia-reperfusion induced color tissue injury, apoptosis and inflammation, but also can improve intrahepatic lipid accumulation, reverse liver fatty degeneration, improve the efficacy of fatty degeneration donor liver transplantation.

Disclosed herein are methods and compositions for preserving or reconditioning organs prior to transplant. The compositions of the present invention contain plasmin and / or functionally active mutants thereof formulated in a pharmaceutically acceptable organ preservation solution. The compositions are stable and non-toxic to the organ intended for transplant.