Organ preservation liquid, its preparation method and use thereof

Abstract

The preservative fluid for organ contains soluble TNF receptor and soluble IL-1 receptor or carrier capable of expressing the described receptor. The application of said preservative fluid can effectively reduce host-versus graft and graft versus host reaction in the process of organ transplantation, can prolong survival time of graft and raise survival rate of graft in host body interior, so that it can be effectively used for organ transplantation.

Description

technical field [0001] The invention relates to the fields of biology and medicine, and more particularly relates to an organ preservation solution for organ transplantation and its preparation method and application. Background technique [0002] At present, organ transplantation is still an important means of treating certain diseases. However, after an organ is removed from a donor and then transplanted into a recipient, it often needs to be kept at a certain temperature. Therefore, in order to prolong the survival time of the graft and improve the survival rate of the graft in the host again, people often use the organ transplant preservation solution to preserve the transplanted organ. Since the rejection reaction during transplantation is related to various factors produced by the immune system, the relationship between various cytokines and immune rejection has always been the focus of research. [0003] TNF-α and IL-1 are the key factors mediating the alloimmune re...

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Problems solved by technology

[0012] However, at present, this kind of preservation solution is only from how to preserve the activity of cells in the tissue, and cannot reduce the graft-versus-host or host-versus-graft reaction in the process of organ transplantation, thereby improving the survival rate after organ transplantation

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