The invention discloses nutritional nourishing hand cream and a preparation method thereof. The hand cream comprises the following components: shea butter, horse oil, wheat germ oil, rose infused oil, snow lotus herb infused oil, myosotis infused oil, universal self-emulsified composite emulsifier, AC-402, 25% triethanolamine, bletilla extract, green tea extract, actinidia chinensis extracted juice, pyracantha fortuneana fruit extracted juice, 1,2-propylene glycol, biological polysaccharide gum, a 20% urea solution, Liponic EG-1, trehalose, nicotinamide, honey, vitamin E, sodium alginate, hydroxypropyl methyl cellulose, a 1% ethylenediamine tetraacetic acid disodium salt solution, a 10% citric acid solution, a 5% ethylparaben solution, distilled water and essence. Compared with the prior art, the hand cream has the advantages of providing rich nutrition to hand skin, deep nourishing dry and rough hands, regulating balance of moisture and oil, softening waste cutin, flattening fine lines, supplying moisture to hands and increasing effects of moistening and whitening.