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Cardioplegic solution containing lidocaine and adenosine and preparation method thereof

A cardioplegic solution and lidocaine technology, applied in the field of cardioplegia solution, can solve the problems of easy inflammatory reaction, inability to carry oxygen, and long time to induce asystole.

Inactive Publication Date: 2014-07-02
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a cardioplegia containing lidocaine and adenosine and a preparation method thereof, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem that the traditional cardioplegia has induced cardiac arrest for too long, Reperfusion is required, arrhythmia is prone to occur after re-beating, myocardial damage is likely to occur, inflammatory reactions are prone to occur, and oxygen cannot be carried

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Accurately weigh the following ingredients:

[0032] Sodium chloride 6.5g; Potassium chloride 2.3g; Magnesium sulfate 0.35g;

[0033] Calcium chloride 0.07g; Glucose 6g; Lidocaine 0.5g;

[0034] Adenosine 130mg; Astragaloside IV 15mg; Coenzyme Q10 75mg;

[0035] Tetrandrine 9mg; higenamine 6mg; histidine 7g.

[0036] (1) Add 800ml of double-distilled water into a container larger than 1000ml, then add sodium chloride, potassium chloride, magnesium sulfate, and calcium chloride in sequence, and stir until the color becomes clear; then add glucose, lidocaine, adenosine, and astragalus Aside, tetrandrine, histidine and higenamine, stir until the color becomes clear; then add coenzyme Q10, stir until the color becomes clear;

[0037] (2) Adjust the pH of the solution to 7.65, the osmotic pressure to 370mOsm / L, distill the volume to 1000ml with double-distilled water, and store at 4°C for later use.

[0038]

Embodiment 2

[0040] Accurately weigh the following ingredients:

[0041] Sodium chloride 6g; Potassium chloride 2.5g; Magnesium sulfate 0.4g;

[0042] Calcium chloride 0.07g; Glucose 7g; Lidocaine 0.4g;

[0043] Adenosine 150mg; Astragaloside IV 17mg; Coenzyme Q10 60mg;

[0044] Tetrandrine 9mg; Higenamine 6mg; Histidine 7g; Other preparation methods are the same as in Example 1.

[0045]

Embodiment 3

[0047] Accurately weigh the following ingredients:

[0048] Sodium chloride 5.0g; Potassium chloride 3.0g; Magnesium sulfate 0.5g;

[0049] Calcium chloride 0.05g; Glucose 8g; Lidocaine 0.6g;

[0050] Adenosine 200mg; Astragaloside IV 10mg; Coenzyme Q10 50mg;

[0051]Tetrandrine 10mg; higenamine 5mg; histidine 5g; other preparation methods are the same as in Example 1.

[0052]

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PUM

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Abstract

The invention relates to the technical field of cardioplegic solutions, in particular to a cardioplegic solution containing lidocaine and adenosine and a preparation method thereof. Every 1,000ml of organ preservation solution comprises the following components by weight: 5.0-7.0g of sodium chloride, 2.0-3.0g of potassium chloride, 0.3-0.5g of magnesium sulfate, 0.05-0.1g of calcium chloride, 5-8g of glucose, 0.3-0.6g of lidocaine, 0.1-0.2g of adenosine, 0.01-0.02g of astragaloside, 0.05-0.08g of coenzyme Q10, 0.005-0.01g of tetrandrine, 0.005-0.01g of higenamine, 5-8g of histidine and the balance of double distilled water.

Description

technical field [0001] The invention relates to the technical field of cardioplegia, in particular to a cardioplegia containing lidocaine and adenosine and a preparation method thereof. Background technique [0002] Since the beginning of heart surgery in the 1960s, pioneers in cardiac surgery have attempted several ways to support the patient's circulation on the one hand and protect the heart on the other. The protective effect of hypothermia has been recognized not only locally in the heart but also in systemic applications. The subsequent development of cardiac surgery has mainly utilized the gradual improvement of extracorporeal circulation components, allowing more and more complex and longer operations to be performed, but unfortunately, the myocardial protection effect has not reached the ideal state, and cardiac arrest still exists after surgery - Reperfusion injury. Therefore, it is necessary to provide a measure of myocardial protection that is better than merel...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P9/00A61K31/167A61K31/7076
Inventor 王寿世宋婷婷徐辉
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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