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Organ preservation solution and method for preparing same
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A technology of organ preservation solution and formula, which is applied in the field of medical devices and can solve the problems of hemorheology, high cost, high viscosity, etc.
Active Publication Date: 2012-10-17
SHANGHAI GENEXT MEDICAL TECH
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[0004] However, this preservation solution also has its inherent disadvantages: (1) high potassium and low sodium, which can easily cause damage to vascular endothelial cells; Aggregation of red blood
Method used
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Embodiment 1
[0091] 1. Double distilled water: Add 800ml double distilled water into a 1000ml container.
[0096] 6. Adenosine: add 2mmol adenosine, stir to dissolve.
[0097]7. Adenine phosphate: add 5mmol adenine phosphate, stir to dissolve.
[0098] 8. L-arginine: Add 2mmol L-arginine and stir to dissolve it.
[0099] 9. Tryptophan: add 2mmol tryptophan, stir to dissolve.
[0100] 10. Reduced glutathione: Add 3 mmol of reduced glutathione, stir to dissolve.
[0101] 11. Trehalose: add 100mmol trehalose, stir until completely dissolved.
[0102] 12. Gluconolactone: Add 40mmol gluconolactone and stir until completely dissolved.
[0103] 13. Polyethylene g...
Embodiment 2
[0108] Add 800ml of double distilled water to a 1000ml container, then add 1.5mmol potassium citrate, 22mmol sodium citrate, 4mmol magnesium sulfate, 26mmol sodium dihydrogen phosphate, 1.5mmol adenosine, 4mmol adenine phosphate, 1.5mmol L-arginine, 1.5mmol tryptophan, 2mmol reduced glutathione, 80mmol trehalose, 30mmol gluconolactone, 0.02mmol polyethylene glycol, 0.01mmol ligustrazine hydrochloride, stirred until completely dissolved, then added Adjust the pH value to 7.5-8 with about 22 mmol of NaOH, add double-distilled water until the total volume of the solution is 1000 ml, and stir to make the solution a uniform, colorless, clear liquid to obtain the organ preservation solution of the present invention.
Embodiment 3
[0110] Add 800ml of double distilled water to a 1000ml container, then add 3mmol potassium citrate, 28mmol sodium citrate, 6mmol magnesium sulfate, 34mmol sodium dihydrogen phosphate, 3mmol adenosine, 6mmol adenine phosphate, 3mmol L-arginine Amino acid, 3mmol tryptophan, 4mmol reduced glutathione, 150mmol trehalose, 50mmol gluconolactone, 0.04mmol polyethylene glycol, 0.02mmol ligustrazine hydrochloride, stir until completely dissolved, then add about 28mmol NaOH to adjust the pH value to 7.5 to 8, add double distilled water until the total volume of the solution is 1000ml, stir to make the solution a uniform, colorless, clear liquid, and obtain the organ preservation solution of the present invention.
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Abstract
The invention relates to an organ preservation solution and a method for preparing the same. The method comprises the following steps of: (1) adopting double buffer pairs of citric acids and phosphates to enable the PH value of a solution to be maintained in a range of 7.5 to 8; (2) adding active ingredients such as adenosine, L-arginine, tryptophan, ligustrazine hydrochloride, reduced glutathione and the like and keep the solution stable; (3) to maintain a hypertonic property of the preservation solution with an osmotic pressure of 350-380 mOsm/L, adopting trehalose and gluconolactone as impermeable substances to effectively prevent cellular edema; and (4) adopting polyethylene glycol with a large molecular weight as a colloidal substance to effectively prevent extracellular space from expanding. Compared with the prior art, the method employs raw materials which are all homemade medicinal components and meet the standards of national pharmacopoeia, and are cheap and free of incompatibility; the organ preservation solution prepared is a colorless and transparent liquid which has stable properties, and can be sterilized by high temperature and high pressure, stored at normal temperature or low temperature, and refrigerated, and thus preparation, transportation, storage and usage of the organ preservation liquid are all very easy and convenient.
Description
technical field [0001] The invention relates to the preservation technology of human or animal organs, tissues or cells in the field of medical devices, and is an organ preservation solution for clinical organ transplantation medicine and a preparation method thereof. Background technique [0002] Organ transplantation has become the only effective cure for end-stage organ failure. High-quality donors are the prerequisite and fundamental guarantee for the success of any clinical organ transplantation. As one of the three pillars of organ transplantation, organ preservation has made significant contributions to this and is the cornerstone of organ transplantation. The fundamental purpose of organ preservation is to minimize the various damages caused by ischemia to the isolated organs, to preserve the effective vitality of the isolated organs, so as to complete the transportation, matching and operation, and to enable the transplanted organs to quickly recover their functions...
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