Organ preservation liquid

Abstract

The invention relates to a (KYL) organ preservation solution. The organ preservation solution is prepared from the following raw materials by weight (dosage g / L): 40 to 45 grams of sucrose, 1 to 3 grams of reducibility glutathione, 3 to 4 grams of adenosine triphosphate, 0.12 to 0.18 gram of ulinastatin, 0.6 to 0.8 gram of magnesium sulfate, 0.5 to 0.8 gram of sodium hydroxide, 2 to 3 grams of potassium dihydrogen phosphate, 2 to 4 grams of disodium hydrogen phosphate, 0.6 to 1 gram of radix salviae miltiorrhizae, 0.6 to 0.9 gram of notoginseng, and 10 to 12 grams of glycine. The organ preservation solution has the advantages that: the organ preservation solution has simple preparation and an equivalent preservation effect compared with the UW solution; the organ preservation solution has a better effect than the UW solution regarding the protection for the hepatocyte functions, the hepar microcirculation and the sinus hepaticus endothelial cells; and the organ preservation solution has low price.

Description

technical field [0001] The invention relates to a preparation for preserving organs in organ transplantation technology, that is, a (KYL) organ preservation solution. Background technique [0002] With the rapid development of organ transplantation technology, the requirements for organ preservation solution are also getting higher and higher. From a single-organ preservation solution to a multi-organ preservation solution, from simple preservation to a combination of preservation and treatment. Belzer [1] summarized the conditions that a successful organ preservation solution should meet as the following six points: 1. Reduce cell edema caused by low temperature storage; 2. Prevent acidification of cells; 3. Prevent cell space expansion during lavage preservation; 4. 1. Prevent or reduce reperfusion injury; 5. Provide a substrate for regeneration of high-energy phosphorylation synthesis; 6. Maintain a stable intracellular environment. [0003] At present, the organ prese...

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Problems solved by technology

[0011] The purpose of the present invention is to overcome the deficiencies of current organ preservation solutions such as high viscosity, high potassium, high price and limited storage time, and provide a kind of organ preservation solution, which is not only equivalent to UW solution in terms of preservation effect, but also Compared with UW liquid, it has a slight advantage in protecting liver cell function, liver microcirculation, and hepatic sinusoidal endothelial cells, and it is easy to prepare and cheap, and is more suitable for my country's national conditions.

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