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Organ preservation liquid containing fluorocarbon emulsifier

A technology of organ preservation solution and fluorocarbon emulsion, which is applied in the field of organ preservation solution to achieve the effects of improving high potassium and low sodium, improving survival rate and improving quality

Inactive Publication Date: 2018-11-23
南京麦荻泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, although lowering the temperature can reduce the hypoxia and nutrient deficiency caused by stagnant blood supply, and reduce the level of tissue degeneration and necrosis, sufficient oxygen and nutrient supply is still required

Method used

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  • Organ preservation liquid containing fluorocarbon emulsifier
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  • Organ preservation liquid containing fluorocarbon emulsifier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The organ preservation solution of the present invention can be realized through the following technical solutions: a kind of organ preservation solution, the formula composition and concentration range (g / 1000ml) are as follows:

[0045] Recipe 1

[0046]

[0047] Emulsion preparation process: first mix perfluorodecane bromide and perfluorooctyl bromide and dissolve on an ultrasonic oscillator, add 10 grams of F68 and 10 grams of lecithin, slowly add 100 ml of pure water and stir fully under a magnetic stirrer , forming colostrum. Dissolve sodium chloride, potassium chloride, potassium hydrogen 2-ketoglutarate, magnesium chloride hexahydrate, histidine monohydrochloride, histidine, tryptophan, and calcium chloride dihydrate in 800 ml of water to prepare The aqueous phase that forms the electrolyte part. Add 20 grams of F68, mannitol, and stabilizer sodium oleate to the water phase, slowly add colostrum in a liquid high-speed shearing machine, homogenize at a speed...

Embodiment 2

[0048] Example 2

[0049] The present invention provides a kind of organ preservation solution, its formula composition and concentration range (g / 1000ml) are as follows:

[0050] Recipe 2

[0051]

[0052]

[0053] Emulsion preparation process: first mix perfluorooctyl bromide and perfluorodecane bromide and dissolve on an ultrasonic oscillator, add 10 grams of F68 and 10 grams of medium-chain triglycerides, slowly add 100 ml of pure water under a magnetic stirrer Stir well to form colostrum. Dissolve N-acetylcysteine, adenosine, glutathione, allopurinol, sodium hydroxide, potassium hydroxide, potassium dihydrogen phosphate, and magnesium sulfate heptahydrate in 800 ml of water to prepare water for the electrolyte part Phase, adjust the pH in the range of 6.8-7.5 with hydrochloric acid. Add 20 grams of F68, hydroxyethyl starch, lactobionic acid (lactone) to the water phase, then add the stabilizer sodium oleate, after fully dissolving, slowly add colostrum in the liq...

Embodiment 3

[0055] The present invention provides a kind of organ preservation solution, its formula composition and concentration range (g / 1000ml) are as follows:

[0056] Recipe 3

[0057]

[0058]

[0059] Emulsion preparation process: first mix perfluoromethylcyclohexylpiperidine and perfluorodecalin and dissolve on an ultrasonic oscillator, add 10 grams of F68 and 10 grams of egg yolk lecithin, slowly add 100 ml of pure water under a magnetic stirrer Stir well to form colostrum. Dissolve glutathione, allopurinol, sodium chloride, potassium chloride, magnesium chloride hexahydrate, and calcium chloride dihydrate in 200 ml of water to form an electrolyte solution; then add histidine, tryptophan, Water-salt histidine and potassium hydrogen 2-ketoglutarate were dissolved in 500 ml of water, and the electrolyte solution was slowly added to the buffer to combine to form an aqueous phase, and the pH value was adjusted to 6.7-7.5 with hydrochloric acid. Add 20 grams of F68, mannitol ...

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Abstract

The invention discloses an organ preservation liquid containing a fluorocarbon emulsifier. The organ preservation liquid comprises an oxygen carrier, a cell oxygen free radical protection agent, an emulsifier, a surfactant, a stabilizer, a thickener for viscosity regulation, an electrolyte solution system, and a buffer salt solution for pH (potential of hydrogen) regulation. The organ preservationliquid has the advantages that the oxygen carrying capacity is two times higher than the oxygen carrying capacity of common organ preservation liquid, the nutritional matters required by maintainingof metabolism of isolated organ cells are provided, and the organs can be preserved at sub-low temperature and low temperature; the preservation effect of the isolated livers, kidneys and lungs can beimproved, and the preservation quality is better than the preservation quality of HTK solution and UW solution.

Description

technical field [0001] The invention relates to an organ preservation solution, in particular to an organ preservation solution containing fluorocarbon emulsion, which is used for the preservation of transplanted organs and belongs to the medical field. Background technique [0002] Organ transplantation depends on high-quality donors, which is a prerequisite for successful transplantation. Organ preservation technology is one of the three pillars of organ transplantation and the cornerstone of organ transplantation. Perfusion of resected donor organs with organ preservation solution and static cryopreservation are the most common known methods of organ preservation. Currently, organ preservation solutions commonly used in clinical practice include UW solution, HTK solution, Euro-Collins solution, and Celsior solution. The main mechanism of these preservation solutions is to play a role by maintaining ion concentration, maintaining osmotic pressure, and adding oxygen free ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/0226
Inventor 巫国谊蔡世珍施晓雷芮晨
Owner 南京麦荻泉生物科技有限公司
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