Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Organ preservation solution and liver in-vitro preservation method

A technology of organ preservation solution and preservation method, which is applied in the fields of organ preservation solution and liver in vitro preservation, which can solve the problems of limited preservation effect and waste of precious liver resources, and achieve the effects of simple operation, reduced liver damage, and strong applicability

Inactive Publication Date: 2021-08-27
JILIN UNIV FIRST HOSPITAL
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional UW solution and HTK solution are not only difficult to repair the donor liver, but because of their limited preservation effect, many marginal donor livers are completely reduced to abandoned livers after using traditional preservation methods, wasting a lot of precious liver resources

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Organ preservation solution and liver in-vitro preservation method
  • Organ preservation solution and liver in-vitro preservation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) SPF grade healthy male wistar rats were fasted for 12 hours before the operation, and were continuously anesthetized with isoflurane gas through a small animal anesthesia machine; after the anesthesia took effect, the rats were fixed on the operating table, and the abdominal hair was removed , 75% alcohol disinfection, laying sterile surgical drapes, using a cross abdominal incision, the upper edge of the incision is to the xiphoid process, the lower edge is the pubic symphysis, and the left and right are horizontal along the lower edge of the costal arch.

[0026] The xiphoid process was turned upward with vascular forceps, and the abdominal wall on both sides was pulled and fixed by the retractor to keep the operative field in good condition. Gently push the gastrointestinal tract in the abdominal cavity to the left iliac area with a cotton swab, cover it with saline gauze to moisturize, bluntly dissect the perihepatic ligament and abdominal aorta, and inject 1ml o...

Embodiment 2

[0029] SPF grade healthy male wistar rats were selected without food and water for 12 hours before the operation, and were continuously anesthetized with isoflurane gas through a small animal anesthesia machine; after the anesthesia took effect, the rats were fixed on the operating table, and the abdominal hair was removed, 75% Alcohol disinfection, laying sterile surgical drapes, using a cross abdominal incision, the upper edge of the incision is to the xiphoid process, the lower edge is the pubic symphysis, and the left and right are horizontal along the lower edge of the costal arch.

[0030] The xiphoid process was turned upward with vascular forceps, and the abdominal wall on both sides was pulled and fixed by the retractor to keep the operative field in good condition. Gently push the gastrointestinal tract in the abdominal cavity to the left iliac area with a cotton swab, cover it with saline gauze to moisturize, bluntly dissect the perihepatic ligament and abdominal aor...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention is applicable to the technical field of medical treatment, and provides an organ preservation solution and a liver in-vitro preservation method, the organ preservation solution comprises the following components: a UW solution and resveratrol; the combined use of the resveratrol and the UW liquid can reduce liver enzymatic injury markers and improve the liver tissue form, which indicates that the combined use of the resveratrol and the UW liquid can effectively improve the donor liver quality and reduce the donor liver injury; particularly, a remarkable protection effect is achieved in static cold preservation of liver transplantation donor liver; and the problems that an existing organ preserving fluid is difficult to repair the liver of a donor, but due to the limited preserving effect of the organ preserving fluid, many marginal donor livers completely fall into waste livers after a traditional preserving mode is applied, and a large number of precious liver sources are wasted are solved.

Description

technical field [0001] The invention belongs to the field of medical technology, in particular to an organ preservation solution and a liver preservation method in vitro. Background technique [0002] Since Dr. Thomas E. Starzl performed the first human orthotopic liver transplantation in 1963, liver transplantation has made great progress and development in the past 60 years. However, liver preservation in vitro is still an important factor affecting the prognosis of liver transplantation. Currently, the most widely used method for liver preservation in vitro is static cold preservation of organs with organ preservation solution. However, the main mechanism of organ damage caused by static cold storage of organs is relatively complicated, especially after liver transplantation, blood reflow will cause more serious and complicated ischemia-reperfusion injury, which seriously hinders the development and further development of liver transplantation. Wide range of applications...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01N1/02
CPCA01N1/0226A01N1/0247
Inventor 吕国悦矫春宝孙晓东李明谦
Owner JILIN UNIV FIRST HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com