3 results about "Arteriogenesis" patented technology

The present disclosure relates to 1-(2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)acetyl)-4- hydroxypyrrolidine-2-carboxamide derivatives and structurally related compounds of formula (I) as VHL inhibitors for the treatment of e.g. anemia (e.g. chronic anemia or anemia associated with chronic kidney disease, dialysis or cancer chemotherapy), ischemia, stroke or injury to the cardiovascular system during ischemia, or for enhancing wound healing, reducing scarring or enhancing angiogenesis or arteriogenesis.

The invention belongs to the technical field of biological pharmacy, and provides an application of a serum LECT2 level in cardiac remodeling and coronary angiogenesis prediction after myocardial infarction, and the application is that the serum LECT2 level is used as a marker to be applied to cardiac remodeling and coronary angiogenesis prediction after myocardial infarction. By establishing a myocardial infarction animal model and comparing serum LECT2 levels in blood of healthy people, myocardial infarction patients and coronary artery occlusion patients, the prognosis effect of the serum LECT2 expression level in myocardial infarction and coronary artery occlusion diseases is evaluated. Results show that the serum LECT2 level can be used as an effective index for predicting coronary angiogenesis after myocardial infarction and prognosis of patients, and clinicians can adjust a treatment scheme in time and optimize patient management by detecting the serum LECT2 level.

The present disclosure relates to 1-(2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)acetyl)-4- hydroxy-N-(benzyl)pyrrolidine-2-carboxamide derivatives and structurally related compounds, which are useful as VHL inhibitors for the treatment of, for example, anemia (e.g., chronic anemia or anemia associated with chronic kidney disease, dialysis, or cancer chemotherapy), ischemia, stroke, or injury to the cardiovascular system during ischemia, or for enhancing wound healing, reducing scarring, or enhancing angiogenesis or arteriogenesis, as well as cancer.