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Adding method of granule flavor

A technology of granules and flavors, which is applied in the field of adding flavors to pharmaceutical preparations. It can solve the problems of unsustainable fragrance retention time of liquid flavors and high volatility of flavors, and achieve the effects of solving compliance problems, keeping fragrance intact and improving stability.

Inactive Publication Date: 2013-10-23
贵州省科晖制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing fragrance adding method is to spray liquid essence directly on the granules, and the volatility of each component molecule of the essence is often high, which leads to the unsustainable fragrance retention time of the liquid essence in the granules

Method used

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  • Adding method of granule flavor

Examples

Experimental program
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Effect test

experiment example 1

[0024] A method for adding banana flavor of Ankahuangmin granules for children, comprising the following steps:

[0025] (1) Take β-cyclodextrin and edible gelatin, stir and heat to dissolve, cool, stir evenly, slowly add banana edible liquid essence, wherein the ratio of banana essence, β-cyclodextrin, and edible gelatin is 1 : 1 : 1, After fully stirring for 1 hour, dry at 60°C to make flavor and corrective agent;

[0026] (2) Mix the flavor and flavoring agent and Pediatric Anka Huangmin Granules at a ratio of 1:100 for 10 minutes to obtain the banana-flavored Pediatric Anka Huangmin Granules.

[0027] Fragrance duration test:

[0028] The fragrance retention time of the essence in the granules is proved by the GC / MS measurement of the volatile components such as the essence in the banana-flavored Xiaoer Ankahuangmin granules that have been placed for 24 months.

[0029] GC / MS Determination of Volatile Components in Banana Flavored Xiaoer Ankahuangmin Granules

[0030]...

experiment example 2

[0041] A method for adding pineapple flavor of Ankahuangmin granules for children, comprising the following steps:

[0042] (1) Take β-cyclodextrin and edible gelatin, stir and heat to dissolve, cool, stir evenly, slowly add pineapple edible liquid essence, wherein the ratio of pineapple essence, β-cyclodextrin, and edible gelatin is 1 : 5 : 5, After fully stirring for 2.5 hours, dry at 70°C to make flavor and corrective agent;

[0043] (2) Mix the flavor and flavoring agent and Pediatric Anka Huangmin Granules at a ratio of 2:100 for 20 minutes to obtain Pineapple Flavored Pediatric Anka Huangmin Granules.

[0044] Fragrance duration test:

[0045] The fragrance retention time of the essence in the granules is proved by the GC / MS measurement of the volatile components such as the essence in the pineapple-flavored Xiaoer Ankahuangmin granules that have been stored for 24 months.

[0046] GC / MS Determination of Volatile Components in Pineapple Flavored Xiaoer Anka Huangmin ...

experiment example 3

[0058]A method for adding lemon flavor of children's ammonia coffee Huangmin granules, comprising the following steps:

[0059] (1) Take β-cyclodextrin and edible gelatin, stir and heat to dissolve, cool, stir evenly, slowly add lemon edible liquid essence, wherein the ratio of lemon essence, β-cyclodextrin, and edible gelatin is 1 : 10 : 10, After fully stirring for 5 hours, dry at 80°C to make flavor and corrective agent;

[0060] (2) Mix the flavor and flavoring agent and Pediatric Anka Huangmin Granules at a ratio of 1:100 for 30 minutes to obtain lemon flavored Pediatric Anka Huangmin Granules.

[0061] Fragrance duration test:

[0062] The fragrance retention time of the essence in the granules is proved by the GC / MS measurement of the volatile components such as the essence in the lemon-flavored Xiaoer Ankahuangmin granules that have been placed for 24 months.

[0063] GC / MS Determination of Volatile Components in Lemon Flavored Xiaoer Ankahuangmin Granules

[0064...

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Abstract

The invention discloses an adding method of a granule flavor. The adding method comprises the following steps of: stirring, heating and dissolving beta-cyclodextrin and edible gelatin, cooling and uniformly stirring; slowly adding an edible liquid flavor, and drying at 60-80 DEG C after adequately stirring for 1-5 hours, so as to prepare a flavor corrigent, wherein the proportion of the liquid flavor to the beta-cyclodextrin to the edible gelatin is 1:(1-10):(1-10); and mixing the flavor corrigent with a granule in a proportion of (1-2):100 for 1-30 minutes, thus obtaining the aromatized granule. According to the adding method of the granule flavor, the stability of the flavor in the granule is greatly improved, the volatilization loss of the flavor is inhibited, and the fragrance is completely maintained, so that the release time of the granule flavor is prolonged due to the slow release of the granules, and a medicine can still have the fragrance during the period of validity.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a method for adding essence to pharmaceutical preparations. [0002] Background technique [0003] With the advancement of science and technology and the improvement of living standards, people's requirements for drug compliance are getting higher and higher, especially for children's series of drugs. Pediatric medications are special and have high requirements for the sense of taste and smell of medicines. Therefore, sweeteners and flavors are generally added to pediatric medications. The existing fragrance adding method is to directly spray the liquid essence on the granule, and the volatility of each component molecule of the essence is often relatively high, so that the fragrance retention time of the liquid essence in the granule cannot be sustained for a long time. [0004] Contents of the invention [0005] The object of the present inventio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/42
Inventor 高玉琼刘建华崔伟霍昕刘文炜杨迺嘉
Owner 贵州省科晖制药有限公司
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