The invention relates to a high-efficiency and low-toxicity compound insecticide which consists of clothianidin and pymetrozine and is particularly used for application research on controlling rice plant hopper. The insecticidal composition contains clothianidin and pymetrozine and is prepared from the following raw materials in percentage by weight: 0.1 to 50 percent of clothianidin, 60 to 0.1 percent of clothianidin, and the balance of aids and carriers. The insecticidal composition is applied to the control over various pests such as hemiptera pests, coleopteran pests, diptera pests, certain lepidoptera pests on rice, vegetables, fruit trees and other plant, such as plant hopper and aphid, leafhopper, thrip, cnaphalocrocis medinalis, chilo suppressalis, myzus persicae, black peach aphid, pear psylla, whitefly and the like. Aiming at the conditions of high difficulty in controlling plant hopper and increased resistance in the current market, the clothianidin and the pymetrozine are reasonably compounded according to the control experimental effects of clothianidin on plant hopper, a clothianidin and pymetrozine compounded control composition is researched, the defects that the resistance and a control object of the conventional nicotine products in the current market are single, so control cost is increased due to multiple times of using insecticides are overcome, and the invention provides the insecticidal composition which contains clothianidin and pymetrozine and has the synergistic effects, and application of the insecticidal composition.