The invention belongs to the field of pesticide, which mainly relates to an ultralow-volume solvent containing pleocidin or spinetoram. The ultralow-volume solvent is an active component I or an active ingredient compounded by the active component I or an active component II, and the balance is solvent and accessory ingredient, wherein the active component I is pleocidin or spinetoram; and the active component II is insecticide of the other type of action mechanism. The ultralow volume solvent is simple to process and has the advantages of water conservation, high work efficiency, long efficacy continuing period, small possibility of generating resistance to drug for a target, small environment pollution, synergy and the like. Ultralow volume spraying, low-volume spraying or low-volume electrostatic spraying is applied to effectively prevent and control various pests, such as Cnaphalocrocis medinalis, Chilo suppressalis, rice planthopper, Ostrinia nubilalis, plutella xylostella, cabbage caterpillar, Spodoptera litura, Spodoptera exigua, aphids, Lesser green leaf hopper, Icerya purchase, aleyrodid, Thrip, stinkbug, acridid, flea beetle, leafminer, looper and the like.