The invention discloses novel plant source insecticidal bactericide and a preparation process thereof. The novel plant source insecticidal bactericide is prepared from, by mass, veratrine, matrine, pyrethrin, fructus cnidii, ethanol, lecithin and water. The preparation process includes the following specific preparation steps that veratrum nigrum, radix sophorae flavescentis, pyrethrum carneum and fructus cnidii are taken, subjected to impurity removal, completely cleaned, placed in an oven at the temperature of 40 DEG C to be dried to constant weight, and then smashed into particles, and lecithin is added for vibration and filtration; an ethanol solution is added for extraction, and raw drugs of eratrine, matrine, pyrethrin and fructus cnidii are prepared respectively; ethanol and water are added to the raw drugs, after mixing, settling and filtering are conducted, and the novel plant source insecticidal bactericide is obtained. The novel plant source insecticidal bactericide is a wide-spectrum insecticidal bactericide, and is long in lasting period and remarkable in pesticide effect, the comprehensive prevention effect is 80% or above, a good control effect is achieved on aphids, oulema oryzae, gall mites, chilo suppressalis, tryporyza incertulas, rice planthopper, locusts and the like, environment friendliness is achieved, and no pesticide residue is generated.