Long-acting breast injection agent for treating cow mastitis in dry period and preparation method of long-acting breast injection agent

An udder injection and dry milk period technology, which can be applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc. Pathogen resistance and other problems, to achieve the effect of promoting damaged tissue repair and immune regulation, reducing antibiotic residues, and lasting efficacy

Active Publication Date: 2016-09-21
QILU ANIMAL HEALTH PROD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the single use of antibiotics can easily induce drug resistance of pathogenic bacteria and easily lead to antibiotic residues, which will affect the treatment effect of dairy cow mastitis and the quality of dairy products, and have adverse effects on the development of the dairy industry and human health.

Method used

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  • Long-acting breast injection agent for treating cow mastitis in dry period and preparation method of long-acting breast injection agent
  • Long-acting breast injection agent for treating cow mastitis in dry period and preparation method of long-acting breast injection agent
  • Long-acting breast injection agent for treating cow mastitis in dry period and preparation method of long-acting breast injection agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Long-acting udder injection for the treatment of dry milk mastitis in dairy cows. The components per 100g are as follows:

[0042]

[0043] The preparation method is as follows:

[0044] (1) Add the prescription amount of aluminum distearate to part of the liquid paraffin, heat at 145°C with constant stirring, so that the sustained-release agent is fully dissolved and stirred uniformly, and the temperature is lowered to prepare a sustained-release liquid;

[0045] (2) Dissolve the prescription amount of glyceryl monostearate and the prescription amount of butylated hydroxytoluene (BHT) in the remaining liquid paraffin, stir and disperse evenly to prepare an emulsion;

[0046] (3) Mix the sustained-release liquid prepared in step (1) with the emulsified liquid prepared in step (2), and after stirring uniformly, add the prescribed amount of micronized cefalonine and tanshinone extracts to the material liquid In the medium, 50Hz ultrasound and emulsification with a high-speed shea...

Embodiment 2

[0048] Long-acting udder injection for the treatment of dry milk mastitis in dairy cows. The components per 100g are as follows:

[0049]

[0050] The preparation method is the same as in Example 1.

Embodiment 3

[0052] Long-acting udder injection for the treatment of dry milk mastitis in dairy cows. The components per 100g are as follows:

[0053]

[0054] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a long-acting breast injection agent for treating cow mastitis in dry period and a preparation method of the long-acting breast injection agent. The long-acting breast injection agent is prepared from the following raw materials: cefalonium, a tanshinone extract, a slow-release agent, an emulsifier, an antioxidant and an oily solvent. The breast injection agent provided by the invention is mainly used for preventing and treating clinical mastitis and subclinical mastitis caused by staphylococcus aureus, streptococcus, Escherichia coli and the like, has the characteristics of long-lasting property, high stability and high efficiency, and has good clinical application value and market prospects.

Description

Technical field [0001] The invention relates to a long-acting udder injection for treating dry cow mastitis and a preparation method thereof, in particular to a long-acting udder injection containing cefalonine and a preparation method thereof, belonging to the technical field of veterinary medicine preparations. Background technique [0002] Dairy cow mastitis is a common and frequent disease in dairy cows. Its prevention and treatment are difficult and costly. Not only does it cause huge economic losses to production, but it also becomes an important factor that hinders the rapid development of dairy cattle breeding. [0003] Cow mastitis is divided into two types: invisible mastitis and clinical mastitis. It is caused by pathogenic microorganisms invading breast tissue. There are many kinds of pathogenic microorganisms. According to statistics, there are more than 130 species. There are more than 20 clinically common pathogens. Species, of which Staphylococcus aureus, Streptococ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/546A61K9/107A61K47/12A61P31/04A61P15/14
CPCA61K9/0002A61K9/0041A61K9/107A61K31/546A61K31/58A61K47/12A61K2300/00
Inventor 王海挺梁秀婷朱祈明孟双双韩文王甜孔梅吴连勇
Owner QILU ANIMAL HEALTH PROD
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