38results about How to "Has sustained release properties" patented technology

The invention provides a long-acting slow-release microcapsule food antistaling agent and a preparation method thereof. The antistaling agent comprises natural antiseptic patchouli oil as the core material and natural polymer chitosan and gelatin as the wall materials. The antistaling agent is prepared by complex coacervation, comprising the following steps: preparing a chitosan-acetic acid solution and a gelatin solution, uniformly mixing 0.5-3.0wt% of the chitosan-acetic acid solution and 1.0-3.0wt% of the gelatin solution, then adding a certain amount of patchouli oil and emulsifier, emulsifying for a certain time under stirring, and then regulating the pH value of the system to a proper value, after completing the complex coacervation reaction, adding 10wt% of vanillin-alcohol solution to conduct curing crosslinking reaction for a certain time, and finally conducting pumping filtration, washing and freeze drying to obtain the powdery microcapsule food antistaling agent. The antistaling agent has the particle size of 1-10 mum, good sphericity and dispersibility, the embedding rate of 85-92%, the drug-loading rate of 30-40%, and significant slow release effect, and has no toxicity, safety, and long acting and lasting fresh-keeping and anticorrosion effects. The preparation method has the advantages of simple and easiness in operation, good repeatability, low requirement for devices, no toxicity and nature of raw materials, wide obtainment of sources, and low production cost, and is suitable for industrial production.

The invention discloses corrosion inhibitor microcapsules based on graphene rolls. The microcapsules adopt graphene as a capsule wall material and adopt an organic corrosion inhibitor as a core material. The invention further discloses a preparation method of the microcapsules. After a water solution of the organic corrosion inhibitor is blended with graphene oxide, the mixture is subjected to hydrothermal treatment at 80-200 DEG C for 8-24 h, the corrosion inhibitor is coated with the microcapsules while graphene is rolled under the hydrothermal condition, the core material coating quality is high, and the slow release characteristic of the corrosion inhibitor is good. The method adopts a simple coating process, is convenient to operate and low in preparation cost, and does not need additional aids.

The cigarette with super low free radical content features its delayed released plant polyphenol microcapsule content of 0.02-0.6 wt% of shredded tobacco. The plant polyphenol microcapsule is first dissolved in water, alcohol, mixture of water and alcohol or water solution of propylene glycol and the solution is then sprayed to shredded tobacco. The delayed released plant polyphenol microcapsule may be catechin microcapsule, gallic acid microcapsule as degraded product of tannin or grape polyphenol microcapsule. The added plant polyphenol has stability raised by 9-12 times, extraneous antioxidant performance raised by 5-6 times and intracorporal antioxidant performance raised by about 10 times. Its effective component may be absorbed by oral cavity and respiratory system to eliminate free radical in body while meeting the need of smokers.

The invention relates to a technological method for producing a composite probiotic two-layer microcapsule by virtue of a double-emulsification method-spray drying which is suitable for various activeprobiotic composite micro-ecological preparations, which belongs to the technical field of food microorganisms. The two-layer microcapsule prepared by adopting the double-emulsificaiton-spray dryingmethod is high in probiotic embedding efficiency, good variable bacteria stability, complete in surface and is in an approximate spherical shape; and moreover, the embedded component is released afterpassing by two interfaces, so that the burst release phenomenon can be overcome, the release time can be prolonged, and the controlled-release performance is good. The production device is simple, the operation is convenient, the labor protection is facilitated, the process period is short, the productivity is high, the finished product has good acid tolerance and cholate resisting capability, the source of raw materials is wide, the price is low, the industrialized continuous mass production can be realized, and a foundation can be laid for the industrialized production of the probiotic products.

The invention provides a preparation method of a slow release type fruit and vegetable sterilizing fresh keeping agent. Raw materials of the slow release type fruit and vegetable sterilizing fresh keeping agent comprise distilled water, beer dry yeast, majoram essential oil and anhydrous alcohol. The preparation method comprises the following steps of firstly adding the beer dry yeast to a given amount of the distilled water for activation, then adding an appropriate amount of the majoram essential oil, performing stirring for a definite time, enabling the majoram essential oil to enter the inner parts of yeast cells through permeation and diffusion effects to form microcapsules, then performing centrifuging, performing vacuum filtration on sediments, washing filter residues with anhydrousalcohol, washing away the majoram essential oil which is not embedded, and performing vacuum freeze drying on filter residues so as to obtain the slow release type fruit and vegetable sterilizing fresh keeping agent capable of slowly releasing the majoram essential oil. The slow release type fruit and vegetable sterilizing fresh keeping agent can be encapsulated with ventilated non-woven fabric bags when being used, the majoram essential oil which is slowly released can restrain propagation and growth of bacterial colonies, can reduce rot of fruits and vegetables and achieve the purpose of keeping fresh through destroying the permeability of cell membranes of pathogenic bacteria.

The present invention relates to a docetaxel nanometer lipid injection. The invention also relates to a method for preparing the docetaxel nanometer lipid injection. The invention further relates to the application of the docetaxel nanometer lipid injection for preparing medicament for treating a tumor. The nanometer preparation of the invention is capable of prolonging the medicament action time, conveying the medicament with a target, reducing the administration dose under the precondition of ensuring the medicament action, alleviating or avoiding medicament toxin and side effects, improving the medicament action stability, and being benefited for the medicament storage, thus it is capable of implementing the development of the medicament which has advantages in the aspects of a high yield, automatization, large scale, low cost, convenient carry and storage, small dose and low side-effect.

The invention provides a preparation method of oregano essential oil nano-microcapsules. The preparation method of the oregano essential oil nano-microcapsules mainly comprises the following steps: firstly, correspondingly dissolving gelatin and Arabic gum; then uniformly mixing; adding oregano essential oil into a mixed solution and homogenizing; then adjusting the pH (potential of Hydrogen) to be acidic by utilizing 10 percent glacial acetic acid and continually stirring for certain time; then taking out; cooling to about 10 DEG C in an ice-water bath; adjusting the pH to be 6.0 by utilizing10 percent sodium hydroxide; adding glutamine transaminase; continually stirring and curing; standing and filtering to obtain a nano-microcapsule solution; pre-cooling the nano-microcapsule solutionat -20 DEG C for 24h; and then freezing and drying under a pressure vacuum condition of 1Pa for not less than 24h to obtain solid-state nano-microcapsules. According to the preparation method providedby the invention, the oregano essential oil can be slowly released and the acting time of the oregano essential oil is prolonged.

The invention discloses a preparation method of fishy-smell-removed bighead carp slices based on slow release of fresh ginger essential oil microemulsion. The preparation method comprises the following steps of preparing the fresh ginger essential oil microemulsion by using the raw materials of fresh ginger essential oil, ethanol, nisin, tea polyphenols, an emulsifying agent and the like; pretreating bighead carps to obtain bighead carp slices of which the thickness is 4-6mm; soaking the treated bighead carp slices in the fresh ginger essential oil microemulsion, and then performing draining;and performing vacuum packing on the bighead carp slices obtained in the step C. The fishy-smell-removed bighead carp slices prepared by the method disclosed by the invention have the characteristicsthat the effect of removing fishy smell is good, and the duration is long.

The invention provides a bulleyaconitine A lipidosome freeze-dried powder injection and a preparation method thereof. The injection mainly comprises the following compositions by weight ratio: bulleyaconitine A:phospholipid:cholesterol:freeze-dry protecting agent=1:1-60:1-10:1-360. The prepared freeze-dried powder injection with encapsulation rate of between 75 and 90 percent not only can obviously improve storage stability, but also can lead the bulleyaconitine A lipidosome freeze-dried powder to be re-dissolved after injection water is added. The prepared bulleyaconitine A lipidosome freeze-dried powder injection has light or non irritation in clinic application compared with the prior bulleyaconitine A injection, and has slow release property compared with common preparation.

The invention discloses slow release fertilizer used for potted leafy plants and a preparation method thereof. The slow release fertilizer is prepared from urea formaldehyde rubber powder, copper sulfate, ferrous chloride, borax, magnesium chloride, zinc sulphate heptahydrate, potassium humate, animal waste, traditional Chinese medicine residues and ash, mushroom residues, animal bones, knar clay and the like. The prepared slow release fertilizer is low in cost and easy and convenient to apply; mineral substances and microelements, such as nitrogen phosphorus and potassium, required for growth of leafy plants are met through various added inorganic substances, and normal growth of leafy plants is ensured; nutrient elements required for plants can be provided through added organic substances such as potassium humate, animal waste and deep sea mineral salt; by matching and retting the raw materials , plants can be dark green and bright in leaf color in the growth process, and the ornamental value of plants is greatly improved; slow release components such as urea formaldehyde rubber powder and ethylene oxide/propylene epoxide copolymers and hydroxypropyl xanthan gum are added, and therefore the prepared fertilizer can have the slow release characteristic, the fertilizer efficiency can be lasting, and growth requirements of potted leafy plants can be met through one-time fertilizer application.

The invention relates to a slow-release fertilizer capable of reducing the content of heavy metal ions in soil and a preparation method thereof. The slow-release fertilizer adopts sodium sulfide, polyvinyl alcohol, aluminum nitrate nonahydrate, magnesium nitrate hexahydrate, lignin and urea as reaction raw materials , a slow-release fertilizer with sulfur-containing hydrotalcite and lignin as carriers was prepared. The sulfur ions in the slow-release fertilizer can form water-insoluble sulfide precipitation with heavy metal ions, so as to reduce the content of migratory heavy metal ions in the soil. release function. The dual-function fertilizer can reduce the environmental pollution caused by excessive heavy metal ions in the soil and reduce the cost of soil treatment while not affecting normal agricultural production.

The invention belongs to the technical field of medicines, and relates to an entecavir-loaded mesoporous silica nanoparticle and a preparation method thereof. The entecavir-loaded mesoporous silica nanoparticle provided by the invention contains entecavir and mesoporous silica nanoparticle. According to the entecavir-loaded mesoporous silica nanoparticle provided by the invention, the bioavailability of the entecavir is improved; the entecavir-loaded mesoporous silica nanoparticle can be slowly released in a body; and according to the preparation method provided by the invention, the drug loading capacity is greatly improved.

The invention relates to a long-acting breast injection agent for treating cow mastitis in dry period and a preparation method of the long-acting breast injection agent. The long-acting breast injection agent is prepared from the following raw materials: cefalonium, a tanshinone extract, a slow-release agent, an emulsifier, an antioxidant and an oily solvent. The breast injection agent provided by the invention is mainly used for preventing and treating clinical mastitis and subclinical mastitis caused by staphylococcus aureus, streptococcus, Escherichia coli and the like, has the characteristics of long-lasting property, high stability and high efficiency, and has good clinical application value and market prospects.

The invention provides a preparation method of an amomum villosum essential oil microcapsule. The preparation method mainly comprises the following steps: by taking amomum villosum essential oil as a core material and one or more of an inulin-lysozyme aqueous solution, an inulin-chitosan aqueous solution, a pectin-lysozyme aqueous solution and a pectin-chitosan aqueous solution as wall materials, adjusting the pH value of a system to 3-10 according to a mass ratio of the amomum villosum essential oil to the nanoparticle aqueous solution of 2: 1-1: 2, stirring at a high speed of 800-1600 r/min to obtain a pickering emulsion product, carrying out ultrasonic dispersion for 30-60 minutes under the power of 200W, and then carrying out spray drying to obtain the amomum villosum essential oil microcapsule. The amomum villosum essential oil microcapsule prepared by the method not only can protect the activity of the amomum villosum essential oil and realize slow release of the amomum villosum essential oil, but also has biological activity of inducing apoptosis of human hepatoma cells HepG2, and can realize wider application of the amomum villosum essential oil in the fields of food, health care products and medicines.

The invention discloses a controllable release halloysite supported molybdate and benzotriazole composite corrosion inhibitor and a preparation method thereof. According to the nano container effect of halloysite and the synergistic effect of MoO4<2-> and BTA; molybdate and BTA are supported into halloysite in sequence through a negative pressure method; meanwhile, an insoluble Cu-BTA compound isformed at the port of the HNTs by utilizing the interaction of BTA and Cu ions at the pipe orifice to slow down the release speed of MoO4 <2-> and BTA in the pipe, so that the corrosion resistance ofthe marine anticorrosive paint is improved and the service life of the marine anticorrosive paint is prolonged through the controlled release and composite corrosion inhibition behaviors of the corrosion inhibitor.

The invention provides an anti-pollution method for a spray bottle. The clathrate containing essential oil is prepared, and then a medicine box for accommodating the clathrate is arranged on the inner wall of the bottle cap of the spray bottle, and the clathrate is placed in the medicine box. The essential oil is volatilized inside the spray bottle, wherein the clathrate is formed by mixing the essential oil with an inclusion agent, or is formed by loading the essential oil on a carrier. The anti-pollution method provided by the present invention uses essential oils derived from natural plants instead of common synthetic antibacterial agents, which has less toxic and side effects and better safety; making essential oils into clathrates with slow-release properties can prolong their use efficacy, Make it work stably for a long time; put the essential oil inclusion compound in the bottle cap of the spray bottle, which can avoid the influence with the substances in the bottle, and can form an antibacterial environment in the spray bottle, thereby solving the problem of bacterial contamination, especially It is the problem of bacterial contamination at the nozzle; the method of the invention has a wide range of sources of raw materials, a simple and convenient production method, and has great potential for large-scale application.

The invention provides a dendritic polymer-vitamin E succinate polyethylene glycol 1000 (PAMAM-TPGS), a preparation method thereof and an application of the dendritic polymer-vitamin E succinate polyethylene glycol 1000 (PAMAM-TPGS) as a drug carrier in preparation of a drug preparation. The dendritic polymer-vitamin E succinate polyethylene glycol 1000 nanoparticles prepared by a micro-channel method, a film dispersion method and an emulsion solvent evaporation method respectively have the characteristics of easiness in industrialization, high drug loading capacity and stable system, can obviously improve the solubility of a model drug in water and realize controllable release, have obvious pharmacological activity, and can be used for preparing a drug carrier for the drug. The device is suitable for various administration modes such as intravenous injection.