Technological method for producing composite probiotic two-layer microcapsule by virtue of double-emulsification method-spray drying

A technology of compound probiotics and double emulsification method, which is applied in the directions of Lactobacillus, Bifidobacterium, Streptococcus/Lactococcus, etc., can solve the problems of not being able to increase the production scale, not being widely used, and low embedding efficiency. High embedding efficiency, no cracks and depressions, and rounded shape

Pending Publication Date: 2018-11-30
SHENZHEN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the actual production and application of probiotic microencapsulation technology, many microencapsulation technologies for live bacteria are currently limited by the problem of not being able to increase the production scale. Most research is limited to the laboratory, especially how to prolong live bacteria. The shelf life of bacterial products, and making them able to resist the harsh environment of the human gastrointestinal tract and exert their probiotic effects have become research hotspots at home and abroad.
And it is not widely used in food products on the market, and the industrial application of embedded probiotics in other food and drug products still needs to do more feasible methods suitable for industrial production
And many prepared single-layer microcapsules have depressions and protrusions on the surface, low embedding efficiency, poor stability, porosity, and serious "explosive release" phenomenon

Method used

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  • Technological method for producing composite probiotic two-layer microcapsule by virtue of double-emulsification method-spray drying
  • Technological method for producing composite probiotic two-layer microcapsule by virtue of double-emulsification method-spray drying
  • Technological method for producing composite probiotic two-layer microcapsule by virtue of double-emulsification method-spray drying

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] refer to figure 1 The process flow diagram of double emulsification method-the technical method of spray drying to produce compound probiotic double-layer microcapsules, including:

[0041] (1), select the wall material: use soybean protein isolate, maltodextrin, and sunflower oil as the composition material of the wall material, and the mass ratio of soybean protein isolate: maltodextrin: sunflower oil is 30% of soybean protein isolate, maltodextrin 30%, 40% of live bacteria mixture in sunflower oil.

[0042] (2), the preparation of initial W / O type emulsion: lipophilic emulsifier lecithin is used as the first emulsifier, and its consumption is 1.5% (m / v), joins in the sunflower seed oil, disperses and mixes evenly at high speed, Emulsify to obtain the inner wall material, then add the compound probiotic live bacteria preparation-probiotic solution to mix, 7500r / min high-speed dispersion emulsification, and obtain the initial W / O type emulsion, the core material addi...

Embodiment 2

[0048] refer to figure 1 The process flow chart of double emulsification method-spray drying technology method for producing compound probiotic double-layer microcapsules, including: (1), select wall material: use soybean protein isolate, maltodextrin, sunflower oil as the composition of wall material Materials, soybean protein isolate: maltodextrin: sunflower oil The mass ratio is 30% of soybean protein isolate, 30% of maltodextrin, and 40% of sunflower oil live bacteria mixture.

[0049] (2), the preparation of initial W / O type emulsion: lipophilic emulsifier lecithin is used as the first emulsifier, and its consumption is 1.0% (m / v), joins in the sunflower seed oil, disperses and mixes evenly at high speed, Emulsify to obtain the inner wall material, then add the compound probiotic live bacteria preparation-probiotic solution to mix, 8000r / min high-speed dispersion emulsification, and obtain the initial W / O emulsion, the core material addition is 10% (v / v) ; High-speed di...

Embodiment 3

[0058] Embodiment 3 effect detection

[0059] Artificial intestinal juice: Take 6.8g of potassium dihydrogen phosphate, add 500mL of water to dissolve, adjust the pH value to 6.8 with 0.4% sodium hydroxide solution; take another 10g of pancreatin, add water to dissolve, mix the two liquids, add water to dilute to 1000mL , that is. Prepare just before use. The measurement results are as follows:

[0060]

[0061] From the above results, it can be seen that compared with the conventional technical solution, the technical solution of the present invention reduces burst release, has a high embedding rate, and has small particle size differences among particles.

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Abstract

The invention relates to a technological method for producing a composite probiotic two-layer microcapsule by virtue of a double-emulsification method-spray drying which is suitable for various activeprobiotic composite micro-ecological preparations, which belongs to the technical field of food microorganisms. The two-layer microcapsule prepared by adopting the double-emulsificaiton-spray dryingmethod is high in probiotic embedding efficiency, good variable bacteria stability, complete in surface and is in an approximate spherical shape; and moreover, the embedded component is released afterpassing by two interfaces, so that the burst release phenomenon can be overcome, the release time can be prolonged, and the controlled-release performance is good. The production device is simple, the operation is convenient, the labor protection is facilitated, the process period is short, the productivity is high, the finished product has good acid tolerance and cholate resisting capability, the source of raw materials is wide, the price is low, the industrialized continuous mass production can be realized, and a foundation can be laid for the industrialized production of the probiotic products.

Description

technical field [0001] The invention belongs to the technical field of food microorganisms, and in particular relates to a technical method for producing compound probiotic double-layer microcapsules by double emulsification-spray drying applicable to various active probiotic compound microecological preparations. Background technique [0002] Common probiotics include bifidobacteria and lactobacilli. Probiotic preparations can be used in the treatment of acute diarrhea, chronic diarrhea, chronic constipation, irritable bowel syndrome, liver injury, nervous system diseases and atopic diseases, etc., and have broad market prospects. However, probiotics will die in large numbers in the gastric acid environment, so the survival rate and stability of probiotics are always a great challenge for probiotics. Only when a large number of surviving probiotics pass through the host's ascending digestive system can they be released in the intestine and colonize the intestinal mucosa to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23P10/30
CPCA23L33/135A23P10/30A23V2400/123A23V2400/113A23V2400/517A23V2400/249A23V2400/533
Inventor 朱俊晨
Owner SHENZHEN POLYTECHNIC
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