Floating microorganism adhesive porous hydrogel and preparation method thereof

Abstract

The invention discloses a preparation method of a floating bioadhesive porous hydrogel. The porous hydrogel is a non-effervescent granule and is prepared by adopting an orifice-coagulating bath method, wherein the method is simple, and reaction conditions are mild. A micropill is prepared from drugs and a carrier, wherein the carrier is a natural high molecular polysaccharide substance, has biocompatibility and bioadhesion, is sensitive to the pH value and does not have toxic side effect. The preparation method of the micropill comprises the following steps of: firstly, adding water-insolubledrugs into a solution containing surfactants, and stirring or ultrasonically dispersing uniformly; stirring at a higher speed; adding polysaccharides for dissolving to form uniform viscous mixture; then adding the mixture into a chitosan coagulating bath containing calcium chloride in a form of droplets for cross-linking curing; washing with water; and drying to obtain the micropill. The preparedmicropill has good floatability, bioadhesion and sustained release property in the stomach, and has bioadhesion and pulsed sustained release property in the intestinal tract.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a floating bioadhesive porous hydrogel and a preparation method thereof. Background technique [0002] The gastric floating drug delivery system refers to a preparation that can maintain its own density less than that of the gastric content after oral administration, and is in a floating state in the gastric juice. Gastric floating sustained-release preparations have great advantages in improving drug efficacy and reducing drug toxicity, and have become one of the hotspots in pharmaceutical research. According to different floating mechanisms, gastric floating preparations can be divided into effervescent floating preparations and non-effervescent floating preparations. Non-effervescent floating preparations float in the gastric juice because their own density is smaller than that of the contents. Effervescent flotation preparations usually contain an effe...

AI Technical Summary

Problems solved by technology

[0006] The existing commonly used porous hydrogel preparation methods include: (1) Freeze-drying method: This method uses the principle of sublimation of a deep-cooled solvent to produce a pore structure to prepare a porous hydrogel. The operation is simple and does not require additional chemistry. Drugs, without high temperature or heating, but the polymers prepared by this method are usually amorphous and have low crystallinity, which may reduce the stability of some drugs; (2) Porogenic method: in the presence of porogens Prepare the gel under certain conditions, and then soak, rinse or dissolve the porogen with water or acid solution, leaving holes in their original positions to obtain a porous structure

The disadvantages are that the process of dissolving, washing, soaking and removing the porogen takes time, which prolongs the material preparation cycle; a small amount of uneluted porogen is easy to remain in the product; the porosity of the pore structure is poor; (3) Emulsion template method: This method prepares an intermediate phase emulsion droplet template. During the polymerization process, the template droplets are evenly dispersed in the polymer continuous phase; hole

The solution polymerization phase separation method may lead to low mechanical properties of the hydrogel, which limits the application of the product; while the modified thermal phase separation method is only suitable for the preparation of temperature-sensitive porous hydrogels, and the pore size and porosity control is more difficult

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