The application discloses an adhesion compound based on
metal inorganic compound for optimizing adhesion performance and a preparation method and application thereof, and belongs to the technical field of biological adhesives. The adhesion compound comprises an adhesion precursor, the adhesion precursor is composed of a
protein-
polyphenol composite hydrogel and a
hydrogen bond breaking small molecule compound, and can perform network reconstruction containing beta-fold formation in an aqueous phase containing a
metal inorganic compound; the
metal inorganic compound has the following characteristics: (a) the
solubility of itself and / or a
hydrolysis product in water at 25 DEG C is less than 0.2 g / 100 mL; (b) the
dissociation constant of a
conjugate acid of an adapted anion is greater than 5; (c) the
dissolution process produces one or more than one of water, gas or non-metallic precipitates. The application discloses for the first time that the release of metal cations is accurately adjusted by adapting metal inorganic compounds to directionally drive the network reconstruction of the adhesion precursor into a dense advanced structure, and the local metal
ion concentration is avoided from being too high to produce stimulation to human tissues, the in-vivo adhesion performance is optimized, and the safe and durable soft and
hard tissue bonding effect is achieved.