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Method for producing fatty acid alkyl esters and/or glycerin
InactiveUS20090069586A1Reduce componentsAvoid leachingNitrogen compoundsFatty acid esterificationGlycerolHigh activity
To provide: a production method using a catalyst which can substantially suppress leaching of active metal components and exhibit high activity for both reactions of transesterification of glycerides and esterification of free fatty acids each contained in a fat or oil; and the catalyst. A method for producing fatty acid alkyl esters and / or glycerin comprising a step of bringing a fat or oil into contact with an alcohol in the presence of a catalyst, wherein the catalyst is at least one catalyst selected from the group consisting of the following (I) to (V):(I) a metal oxide having an ilmenite structure and / or a slyrankite structure;(II) an oxide containing a metallic element belonging to the Group 12 and a metallic element belonging to the Group 4;(III) a mixed oxide containing a metallic element belonging to the Group 12 and a tetravalent transition metallic element;(IV) a metal oxide containing zirconium and at least one metallic element selected from the group consisting of metallic elements belonging to the Groups 4, 5 and 8; and(V) a metal oxide containing anatase type titanium oxide and / or rutile type titanium oxide, and the metal oxide containing a sulfur component of 700 ppm or less.
Owner:NIPPON SHOKUBAI CO LTD +1
Process for the preparation of dronedarone by oxidation of a sulphenyl group
The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.
Owner:SANOFI SA
Compound as well as synthesis thereof and method for synthesizing double-UPy substituted compound by using same
InactiveCN103755644ARaw materials are easy to getHigh isolation yieldOrganic chemistryAlkaneChemical reaction
The invention discloses a compound which is 2[2-(1-ethanethiol)] urea-4 [1H]-pyrimidone. The invention also discloses a synthesis method of the compound, which comprises the steps: enabling cystamine dihydrochloride to react with activated ureido pyrimidine S1 to obtain a 2-urea-4[1H]-pyrimidine disubstituted sulfur-sulfur compound S2; and reducing the sulfur-sulfur compound S2 by using DTT (Dithiothreitol) to obtain the compound. The invention also discloses a method for synthesizing a double-UPy substituted compound by using the compound disclosed by the invention. According to the method, the compound has a free radical thiol-alkynyl click chemical reaction with an alkane alkynyl-terminated compound CHR to obtain the double-UPy substituted compound. According to the method disclosed by the invention, the thiol-alkynyl click chemical reaction is utilized to synthesize the double-UPy substituted compound for the first time; raw materials are easy to obtain, the application range is wide, the separation yield is high, and the synthesis method is scientific and reasonable; therefore a general method is provided for synthesizing the double-UPy substituted compound.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Methods for the synthesis of deuterated acrylate salts
ActiveUS20130079554A1Significant scaleLess-costly and more straightforwardOrganic compound preparationOrganic chemistry methodsPolymer sciencePalladium catalyst
A method for synthesizing a deuterated acrylate of the Formula (1), the method comprising: (i) deuterating a propiolate compound of Formula (2) to a methyne-deuterated propiolate compound of Formula (3) in the presence of a base and D2O: and (ii) reductively deuterating the methyne-deuterated propiolate compound of Formula (3) in a reaction solvent in the presence of deuterium gas and a palladium-containing catalyst to afford the deuterated acrylate of the Formula (1). The resulting deuterated acrylate compounds, derivatives thereof, and polymers derived therefrom are also described.
Owner:UT BATTELLE LLC
New method for synthesis of alkenyl thiocyanate derivative
ActiveCN106167459AReduce usageGood configuration selectivityOrganic chemistryChemical synthesisOrganic solvent
Belonging to the technical field of pharmaceutical chemical synthesis, the invention discloses a method for synthesis of an alkenyl thiocyanate derivative. The method comprises the steps of: adding haloalkyne and thiocyanate as raw materials into a reaction vessel, taking a silver salt as the catalyst and using an organic solvent as the solvent, carrying out heating reaction, then cooling the obtained reacted solution to room temperature, and then performing purification, thus obtaining the alkenyl thiocyanate derivative. The method provided by the invention adopts haloalkyne and thiocyanate as the raw materials to carry out thiocyanation reaction for one-step synthesis of the alkenyl thiocyanate derivative. Use of concentrated sulfuric acid, mercury salt and other dangerous goods is avoided, the reaction raw materials are easily available, the reaction operation is safe and simple, the reaction process is environment-friendly, the substrate has wide applicability, the functional group has strong compatibility, the separation yield is high, the product configuration selectivity is good, the product can be enlarged to gram scale, and the product reserved halogen can be convenient for further conversion.
Owner:SOUTH CHINA UNIV OF TECH
Extraction method of apigenin, pharmaceutical composition for treating diabetes and application thereof
ActiveCN103641807AEffective blood sugar control functionLower blood sugar concentrationOrganic active ingredientsOrganic chemistryAlgluceraseChemistry
The invention relates to the pharmaceutical technical field. The extraction method of apigenin comprises the steps of 1) enzymatically hydrolyzing celery which is taken as a substrate for 10 hours at 30-35 DEG C through a mixing solution of apigenin which is 33-37% and glucosidase which is 43-47% in mass percentage concentration; and 2) ultrasonically extracting enzymatic hydrolysate obtained from the step 1) through an ethanol solution of 70%, condensing an extracting solution, extracting respectively through petroleum ether and ethyl acetate, evaporating the extracting solution, dissolving through ethanol of 70%, and separating and extracting through a high performance liquid chromatograph. The pharmaceutical composition for treating diabetes consists of apigenin and glucobay at mass ratio of 1: (2-5). The extraction method, which extracts apigenin through a multi-enzymatic process, greatly improves extraction yield. The pharmaceutical composition disclosed by the invention not only can effectively control blood sugar but also can avoid circumstances of low blood sugar and rapid weight loss of a patient due to simple use of a diabetes medicine.
Owner:南通大学技术转移中心有限公司
Synthesis method of polysubstituted silole derivative
The invention provides a synthesis method of a polysubstituted silole derivative. The polysubstituted silole derivative is prepared by reacting a 2-(trimethylsilyl)aryl trifluoromethane sulfonate derivative with alkyne in the presence of a catalyst. The synthesis method is pretty high in yield rate, scientific, reasonable, accessible in raw materials, wide in application range, high in separation yield rate, simple in experiment equipment, simple and easy in operation implementation, and conductive to further development and application.
Owner:INST OF CHEM CHINESE ACAD OF SCI +1
Process for preparation of clopidogrel bisulphate form-1
InactiveUS20070191609A1High isolation yieldHigh enantiomeric purityOrganic chemistryClopidogrel bisulphateSolvent
Disclosed herein is a cost effective and industrially feasible process for the preparation of (+) Clopidogrel bisulphate. The present invention further discloses a novel method of precipitation of (+) Clopidogrel bisulphate Form I directly from solvent mix of methanol and acetone in presence of sulfuric acid at a temperature of 25-40° C.
Owner:LEE PHARMA LTD
Silica hybrid dehydroherbac and preparing method thereof
The invention provides silica hybrid dehydroherbac, namely, 1-(3-silica hybrid-3, 3-dimethyl cyclohexyl) butanone. The silica hybrid dehydroherbac is shown in the formula I. The compound is a perfume compound with strong herb fragrance. Under the action of palladium catalysis, an inserting ring expansion reaction is conducted on silacyclobutane by end group alkyne, and after the ring expansion reaction is accomplished, hydrogenation is conducted directly, so that the silica hybrid dehydroherbac is prepared with high yield. According to a method for preparing the silica hybrid dehydroherbac, raw materials are easy to obtain, the application range is wide, the separation production rate is high, experiment devices are simple, operation is easy to conduct, and industrialization is facilitated.
Owner:ZHENGZHOU TOBACCO RES INST OF CNTC
Process for preparation of dronedarone by oxidation of a hydroxyl group
The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof (formula I), which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.
Owner:SANOFI SA
Synthesis method of aromatic vinyl trifluoromethylthio ether compound
The invention discloses a synthesis method of an aromatic vinyl trifluoromethylthio ether compound, and belongs to the technical field of chemical synthesis. According to the synthesis method disclosed by the invention, the aromatic vinyl trifluoromethylthio ether compound is prepared by taking trans-nitro aryl ethylene as a substrate, silver trifluoromethylthio as a thioether reagent and copper trifluoroacetic acid as a catalyst, and adding an oxidizing agent and an additive. Raw materials used by the method are easy to obtain, the reaction is simple to operate, the yield is high, and the substrate universality is good; the obtained aromatic vinyl trifluoromethylthio ether product has important application in the medicine, pesticide and function material fields.
Owner:万博新材料科技(南通)有限公司
Silica hybrid dehydroherbac and preparing method thereof
ActiveCN103524548AStrong herbal aromaStrong ArborvitaeSilicon organic compoundsEnd-groupSilacyclobutane
The invention provides silica hybrid dehydroherbac, namely, 1-(3-silica hybrid-3, 3-dimethyl cyclohexyl-1-alkenyl) butanone. The silica hybrid dehydroherbac is shown in the formula I. The compound is a perfume compound with strong herb fragrance and oriental arborvitae fragrance and is also an important precursor of an organosilicon perfume compound corresponding to the perfume compounds including herbac, Roman musk, helvetolide and the like. Under the action of palladium catalysis, an inserting ring expansion reaction is conducted on silacyclobutane by end group alkyne, and the silica hybrid dehydroherbac is prepared with high yield. According to a method for preparing the silica hybrid dehydroherbac, raw materials are easy to obtain, the application range is wide, the separation production rate is high, experiment devices are simple, operation is easy to conduct, and industrialization is facilitated.
Owner:ZHENGZHOU TOBACCO RES INST OF CNTC
Synthesis method for multi-substituted 2-imidoimidazoline-4,5-diketone
The invention discloses a synthesis method for multi-substituted 2-imidoimidazoline-4,5-diketone. The method comprises the following steps of: firstly reacting substituted carbodiimide and oxalyl chloride in an ether solvent; and then adding organic base of primary amine and non-primary amine to continuously react to produce the multi-substituted 2-imidoimidazoline-4,5-diketone. The method has is a universal method for synthesizing a multi-substitutent 2-imidoimidazoline-4,5-diketone derivative, has the advantages of high yield, readily available raw materials, easiness in operation, high separation yield and convenience in further development and application.
Owner:PEKING UNIV
1, 3-thiazole derivative
InactiveCN103232406AHigh yieldHigh isolation yieldOrganic chemistryAnaestheticsSynthesis methodsSulfur
The invention provides a 1, 3-thiazole derivative and a synthesis method thereof. A 2-acylamino thiazole derivative is prepared from carbodiimide, acyl chloride, a terminal alkyne compound and elemental sulfur. The yield is higher, and the synthesis method is scientific and reasonable, so that a universal method for synthesizing the 2-acylamino thiazole derivative with various substituent groups is provided. The method has the advantages that the raw materials are easily available, and the application range is large, the separating rate is high, experimental devices and operations are simple and easy to operate; therefore, the 1, 3-thiazole derivative can be further developed and used.
Owner:PEKING UNIV
Process for preparing polysubstituted silole
InactiveCN101284844ARaw materials are easy to getHigh isolation yieldSilicon organic compoundsEther solventButadiene Derivatives
The invention provides a general method for synthesizing silole derivate with a plurality of substituents. The general method comprises the following steps that: firstly, 1-trialkylated silicone base-1, 4-dihalo-1 and 3-butadiene derivate are reacted with lithium alkyl in ether solvent at a low temperature; secondly, quaternary amine or acylammonia ligand is added and the mixture is heated up to continue the reaction; thirdly, the mixture is cooled down and electrophilic reagent E+ is added; finally, polysubstituted silole derivate is obtained through the post treatment and the purification of reaction liquid. The method, being scientific and reasonable, has easily obtained raw material, wide application range, high separation yield and simple experimental equipment and operation, and is convenient for further development and application.
Owner:PEKING UNIV
Photochemical synthesis method of imidazolidine compound
The invention belongs to the field of photochemical organic synthesis, and particularly relates to a photochemical synthesis method of an imidazolidine compound. The photochemical synthesis method comprises the step that alcohol reacts with imine in the presence of light and a photocatalyst to obtain the imidazolidine compound. According to the photochemical synthesis method of the imidazolidine compound, the alcohol and imine dissolved in an inert organic solvent are utilized to realize the reaction of synthesis of the imidazolidine compound from the green low-toxic alcohol and imine by controlling the reaction time under the action of the photocatalyst under the induction of ultraviolet light or visible light, and the imidazolidine compound can be obtained. Moreover, the product of the photochemical synthesis method has high yield and good selectivity. The separation yield of the product is up to more than 95% and the selectivity is up to more than 99%. In addition, a preparation process is simple, the product can be obtained by one-step reaction, and the photochemical synthesis method is economical and environmentally friendly, and convenient to operate, and has high practicability.
Owner:BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
Carbohydrate alkyl bonding imidazole type heterocyclic carbene palladium coordination compound as well as preparation method and application thereof
InactiveCN108586558AMild conditionsShort reaction timeSugar derivativesOrganic compound preparationSolubilityPalladium catalyst
The invention provides a carbohydrate alkyl bonding imidazole type N-heterocyclic carbene palladium coordination compound as well as a preparation method and application thereof. A structure of the carbohydrate alkyl bonding imidazole type N-heterocyclic carbene palladium coordination compound is shown in a formula I: the formula (1) is shown in the description, wherein R is alkyl, benzyl or aryl,and n is equal to 2 to 10. According to the carbohydrate alkyl bonding imidazole type N-heterocyclic carbene palladium coordination compound disclosed by the invention, by using natural chiral compound D-glucose with low cost, easy availability, good water solubility and rich stereochemistry as a chiral source of the carbohydrate alkyl bonding imidazole type N-heterocyclic carbene palladium coordination compound, under a condition of no additional addition of an alkaline additive, a carbohydrate alkyl bonding imidazole type N-heterocyclic carbene palladium complex I is synthesized by adoptinga quick one-step method and is used as a palladium catalyst for catalyzing C-C coupled reaction, and no-water no-oxygen reaction conditions are overcome, so that a series of fluorene-derived conjugated small molecular functional materials having novel structures are prepared in a high yield manner.
Owner:GANNAN NORMAL UNIV
Preparation method for 6-carboxylfluorescein
ActiveCN102942553AHigh isolation yieldHigh application valueOrganic chemistrySolventBiological macromolecule
The invention discloses a preparation method for 6-carboxylfluorescein. The method comprises the following steps: a. reacting; b. crystallizing; and c. hydrolyzing. The preparation method prepares 6-carboxylfluorescein by using a metal catalyst of stannic chloride (SnCl4) to selectively catalyze the reaction, and selects an appropriate solvent mixing ratio and an appropriate purification method. Compared with the prior art, the ratio of the required product 6-carboxylfluorescein and the by-product 5-carboxylfluorescein is improved from 1:1 to 2.6:1, and the separation yield is improved from 32% to 61% (1.9 times as much as the past). The method greatly reduces the production cost, simplifies the purification process, provides a practical and efficient novel process method for the preparation of 6-carboxyfluorescein and derivatives thereof which are widely used for fluorescence labeling of biological macromolecules, and has a high application value.
Owner:WUHU HUAREN SCI & TECH CO LTD
Alkynyl imine derivative
InactiveCN103214394AHigh yieldHigh isolation yieldCarboxylic acid nitrile preparationOrganic compound preparationArylSynthesis methods
The invention provides an alkynyl imine derivative and a synthesis method thereof. According to the method, the 1-o-amino aryl substituted alkynyl imine derivative is prepared from carbodiimide, terminal alkyne, benzyne precursors and activated fluorine ions, the yield is high, and the synthesis method is scientific and reasonable, so that the universal method for synthesizing the alkynyl imine derivative with multiple substituent groups is provided. The method has the advantages of easily-obtained raw materials, wide application range and high separation yield; and experimental equipment and operation are simple and feasible, and further development and application are facilitated.
Owner:PEKING UNIV
Methods for the synthesis of deuterated acrylate salts
ActiveUS8829238B2Promote recoveryImprove economyOrganic compound preparationOrganic chemistry methodsPalladium catalystSolvent
Owner:UT BATTELLE LLC
Synthesis method of aryl thiophthene derivative
InactiveCN102070649AHigh yieldHigh isolation yieldOrganic chemistryOrganic synthesisSynthesis methods
The invention discloses a synthesis method of an aryl thiophthene derivative, which belongs to the field of organic synthesis. The method comprises the following steps of: a) mixing and reacting a compound shown as a formula I and a compound shown as a formula II in an ether solvent, wherein a reaction temperature is between the freezing point of the solvent and room temperature; b) adding zinc powder, raising the reaction temperature to be between 110 DEG C and the boiling point of the solvent and reacting so as to obtain the aryl thiophthene derivative shown as a formula III, wherein R1 and R2 independently represent substituted or unsubstituted alkyl with 1 to 18 carbon atoms, naphthenic base with 3 to 6 carbon atoms, aryl with 6 to 12 carbon atoms or heterocyclic aryl with 2 to 12 carbon atoms; Ar represents aryl with 6 to 12 carbon atoms or heterocyclic aryl with 2 to 12 carbon atoms; and X represents halogen. The synthesis method can be applied to organic photoelectric materials and relevant fields.
Owner:PEKING UNIV
Method for synthesizing gamma-carbonyl ester compound by gamma-hydroxied gadoleic acid ester
InactiveCN102146006AReduce usageLow costOrganic compound preparationCarboxylic acid esters preparationOrganic solventDiamine
The invention relates to a method for synthesizing gamma-carbonyl ester compound by gamma-hydroxied gadoleic acid ester. A gamma-hydroxied gadoleic acid ester compound shown as a formula I is reacted at certain temperature in organic solvent in the presence of catalysts of an alcoxyl alkali-earth metal compound and a diamine compound shown as a formula II, and reaction products are quenched, separated and purified to obtain the gamma-carbonyl ester compound III. Through one-step catalysis reaction only, various different substituted gamma-carbonyl ester compounds can be quickly synthesized by the gamma-hydroxied gadoleic acid ester at high yield. The catalysts are wide in sources, cheap and readily-available and have stable chemical properties for light and heat, and transition metals and highly toxic products can be prevented from being used and generated. Compared with the prior art, the method has the advantages of mild reaction condition, obvious operating safety, and obviously widely application range.
Owner:LANZHOU UNIVERSITY
Method for synthesizing quinolin-2-imide derivative
The invention discloses a method for synthesizing a quinolin-2-imide derivative. According to the method, the quinolin-2-imide derivative is prepared by using diaryl iodonium ions, carbodiimide, alkyne and a copper catalyst, the yield is relatively high, the synthesis method is scientific and reasonable, and thus, a universal method for synthesizing the quinolin-2-imide derivative with a variety of substituents by a three-component-reaction one-pot process is provided. According to the method, the raw materials are cheap and readily available, the catalyst is cheap, the applicable range is wide, the yield of separation is high, the regioselectivity is good, and the experimental facilities and operation are easy and feasible, so that further development and application are facilitated.
Owner:PEKING UNIV
A kind of extraction method of apigenin, pharmaceutical composition and application thereof for treating diabetes
ActiveCN103641807BEffective blood sugar control functionLower blood sugar concentrationOrganic active ingredientsOrganic chemistryApigeninHydrolysate
Owner:南通大学技术转移中心有限公司
A kind of synthetic method of aromatic vinyl trifluoromethyl sulfide compound
ActiveCN109336794BGood effectImprove catalytic performanceSulfide preparationChemical synthesisPtru catalyst
The invention discloses a synthesis method of an aromatic vinyl trifluoromethylthio ether compound, and belongs to the technical field of chemical synthesis. According to the synthesis method disclosed by the invention, the aromatic vinyl trifluoromethylthio ether compound is prepared by taking trans-nitro aryl ethylene as a substrate, silver trifluoromethylthio as a thioether reagent and copper trifluoroacetic acid as a catalyst, and adding an oxidizing agent and an additive. Raw materials used by the method are easy to obtain, the reaction is simple to operate, the yield is high, and the substrate universality is good; the obtained aromatic vinyl trifluoromethylthio ether product has important application in the medicine, pesticide and function material fields.
Owner:万博新材料科技(南通)有限公司
Preparation of triazoles by organometallic addition to ketones and intermediates therefor
InactiveUS20050272747A1High isolation yieldIncrease the molar ratioBiocideOrganic active ingredientsTriazole antifungalsKetone
The invention provides a process for the preparation of a compound of the formula: or an acid addition or base salt thereof, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and trifluoromethyl; R1 is C1-C6 alkyl; and “Het” is pyrimidinyl optionally substituted by 1 to 3 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, oxo, benzyl and benzyloxy, comprising reaction of a compound of the formula: wherein R is as previously defined for a compound of the formula (I), with a compound of the formula: wherein R1 and “Het” are as previously defined for a compound of the formula (I) and X is chloro, bromo or iodo, in the presence of zinc, iodine and / or a Lewis acid and an aprotic organic solvent: said process being optionally followed by conversion of the compound of the formula (I) to an acid addition or base salt thereof.
Owner:PFIZER INC
Method for separating formic acid and levulinic acid from hydrate molten salt
PendingCN114315554AEasy to separateReduce energy consumptionOrganic compound preparationPreparation by ester-hydroxy reactionTrans esterificationPropanoic acid
The invention belongs to the technical field of organic synthesis, and particularly relates to a method for separating formic acid and levulinic acid from hydrate molten salt. The method comprises the following steps: reacting under the coexistence of levulinic acid, formic acid and alcohol in hydrate molten salt, respectively reacting formic acid and levulinic acid with alcohol to generate formate and levulinic acid ester, and carrying out ester exchange on formate and levulinic acid to generate levulinic acid ester and formic acid, after the reaction is finished, the reaction liquid contains levulinic acid ester, formate, levulinic acid, formic acid and alcohol, separating the reaction liquid to obtain an organic phase, distilling the organic phase to respectively obtain levulinic acid ester and formate, and hydrolyzing to respectively obtain levulinic acid and formic acid. The method is simple in technological process, low in energy consumption and easy to separate, and the product can be spontaneously separated from the hydrate molten salt, so that the subsequent purification cost is reduced.
Owner:SHANDONG UNIV OF TECH
A kind of synthetic method of chiral carbamate and derivative thereof
ActiveCN104513116BNo metal residue issuesMild reaction conditionsCarbamic acid derivatives preparationOrganic compound preparationAlkaneCarbamate
The invention relates to a synthesis method for chiral carbamic acid ester and a derivative thereof. The synthesis method comprises the following steps: by adopting organic amine as a reaction reagent, conducting nucleophilic addition into an isotactic-structural alternative copolymer of meso epoxy alkanes and CO2 to degrade the alternative copolymer to form high-enantiomeric excess small organic molecules, namely chiral carbamic acid ester, and the derivative thereof. The synthesis has the green chemistry characteristics of being mild in conditions, high in atom economy, high in productive rate and the like; in the nucleophilic addition and degradation process of organic amine, the spatial configuration of the chiral carbon atom of polycarbonate is completely maintained, and a functional hydroxyl carbamic acid ester derivative with the enantiomeric excess being up to 99% can be generated; carbamic acid ester and the derivative thereof are important intermediates for pesticide and medicine, and have wide application prospects in complete synthesis of natural products and drug molecular design.
Owner:DALIAN UNIV OF TECH
Compound, its synthesis and method for synthesizing double upy substituted compound with it
InactiveCN103755644BRaw materials are easy to getHigh isolation yieldOrganic chemistryAlkaneChemical reaction
The invention discloses a compound which is 2[2-(1-ethanethiol)] urea-4 [1H]-pyrimidone. The invention also discloses a synthesis method of the compound, which comprises the steps: enabling cystamine dihydrochloride to react with activated ureido pyrimidine S1 to obtain a 2-urea-4[1H]-pyrimidine disubstituted sulfur-sulfur compound S2; and reducing the sulfur-sulfur compound S2 by using DTT (Dithiothreitol) to obtain the compound. The invention also discloses a method for synthesizing a double-UPy substituted compound by using the compound disclosed by the invention. According to the method, the compound has a free radical thiol-alkynyl click chemical reaction with an alkane alkynyl-terminated compound CHR to obtain the double-UPy substituted compound. According to the method disclosed by the invention, the thiol-alkynyl click chemical reaction is utilized to synthesize the double-UPy substituted compound for the first time; raw materials are easy to obtain, the application range is wide, the separation yield is high, and the synthesis method is scientific and reasonable; therefore a general method is provided for synthesizing the double-UPy substituted compound.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Reaction systems with incorporated chromatography units for enhanced product recovery
ActiveUS8357302B2High yieldHigh recovery rateIon-exchange process apparatusIon-exchanger regenerationChromatographic separationChemical reaction
Product yields in chemical reactions that produce a solid product from a liquid reaction mixture are improved by chromatographically separating certain key impurities from the product mixture prior to crystallization, or from the filtrate after crystallization in which case further product is crystallized from the filtrate. The removal of key impurities either before the first crystallization or between the first and second crystallizations facilitates the crystallization of product to produce a higher yield of product.
Owner:AEROJET FINE CHEM LLC
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