Compound, its synthesis and method for synthesizing double upy substituted compound with it

A synthesis method and compound technology, applied in the field of compound, its synthesis and the synthesis of double UPy substituted compounds, can solve the problems of increasing the synthetic burden of double UPy substituted compounds, difficulty in synthesizing aromatic compounds, restricting the development of supramolecular materials, etc. The method is scientific and reasonable, the scope of application is wide, and the raw materials are easily available.
CN103755644BInactive Publication Date: 2015-10-21TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2015-10-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a compound which is 2[2-(1-ethanethiol)] urea-4 [1H]-pyrimidone. The invention also discloses a synthesis method of the compound, which comprises the steps: enabling cystamine dihydrochloride to react with activated ureido pyrimidine S1 to obtain a 2-urea-4[1H]-pyrimidine disubstituted sulfur-sulfur compound S2; and reducing the sulfur-sulfur compound S2 by using DTT (Dithiothreitol) to obtain the compound. The invention also discloses a method for synthesizing a double-UPy substituted compound by using the compound disclosed by the invention. According to the method, the compound has a free radical thiol-alkynyl click chemical reaction with an alkane alkynyl-terminated compound CHR to obtain the double-UPy substituted compound. According to the method disclosed by the invention, the thiol-alkynyl click chemical reaction is utilized to synthesize the double-UPy substituted compound for the first time; raw materials are easy to obtain, the application range is wide, the separation yield is high, and the synthesis method is scientific and reasonable; therefore a general method is provided for synthesizing the double-UPy substituted compound.
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Description

technical field

[0001] The invention relates to a compound, its synthesis and a method for synthesizing a double UPy substituted compound, belonging to the field of organic synthesis. Background technique

[0002] The self-complementary quadruple hydrogen bond functional group 2-urea-4[1H]-pyrimidinone (UPy) has been widely developed since Meijer's invention due to its strong complexation and directionality. UPy-based supramolecular polymers have achieved many satisfactory results in the construction of functional materials. The double UPy substituted compounds are the basis for the formation of supramolecular polymers.

[0003] At present, the synthesis of double-UPy substituted compounds mainly uses the reaction of diamino compounds with activated ureidopyrimidinone compounds, or the reaction of isocytosine with diisocyanates. However, diamino compounds are not easy to synthesize, and it is often necessary to reduce the azide or nitro group under harsh conditions; at the...

Claims

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