39results about How to "Narrow emission peak" patented technology

The invention discloses a fluorine-boron fluorescent dye as well as a preparation method and application thereof, wherein the structure of the fluorine-boron fluorescent dye is shown as a formula (I) or a formula (II), in the formula (I) and the formula (II), R1 is H or halogen; R2 is CN; R3, R4, R5 and R6 are independently selected from H, halogen, C1-C6 alkyl or C1-C6 alkoxy; V, W, X, Y and Z are independently CH or N, and when V, W, X, Y or Z is N, N has no substituent group. According to the fluorine-boron fluorescent dye and the preparation method thereof, the maximal fluorescence emission wavelength of the fluorine-boron fluorescent dye is 518-600nm, and the fluorine-boron fluorescent dye also has excellent fluorescence quantum yield and Stokes shift, which shows that the fluorine-boron fluorescent dye has good application prospect in the bioanalysis fields of fluorescence labeling, bioimaging and so on; meanwhile, the preparation method is simple in steps, and raw materials can be obtained easily.

The invention relates to a near-infrared truxene-based conjugate dual-BODIPY fluorescent dye and a preparation method thereof. The fluorescent dye is synthesized by virtue of Knoevenagel condensation reaction of a BODIPY derivative and dialdehyde-containing truxene under the catalysis of p-toluenesulfonic acid and piperidine. The preparation method has the beneficial effects of simple reaction steps, mild reaction conditions and relatively good selectivity. The fluorescent dye has excellent physical properties of relatively high molar extinction coefficients, good solubility and light stability and the like, the highest electronic absorption spectrum red shift reaches above 650nm, the fluorescence emission wavelength reaches 680nm, and the fluorescent dye has very high application prospects. The fluorescent dye has good potential application prospects in the fields of cell imaging, bio-labeling or photoelectric materials and the like.

The invention discloses amphiphilic segmented copolymers, nanoparticles containing the amphiphilic segmented copolymers, a preparation method of the amphiphilic segmented copolymers and a use of the nanoparticles. The amphiphilic segmented copolymers are shown in the structural formulas (I) to (IV). In the structural formulas (I) to (IV), R1 represents H or methyl, R2, R3 and R5 represent H, alkyl or aryl, R4 represents hydroxyl or methyl, x is an integer of 3-20, Spacer is a spacer arm, the spacer arm is optional, and when the spacer arm exists, the spacer arm is one of an ester group, an alkyl group, a triazole group and a thioether group. The nanoparticle obtained by chelating of the amphiphilic segmented copolymer and rare earth ions has good biocompatibility, has excellent fluorescence imaging performances and MRI imaging performances and has a wide application value in the field of medicine and biology and especially in breast cancer diagnosis and treatment.

The invention provides a preparation method of a fluorescent material based on organic and inorganic hybrid perovskite quantum dots. The preparation method comprises the following steps: A) mixing silica sol, a first organic amines compound and organic and inorganic hybrid perovskite quantum dots, and drying the mixture to obtain the fluorescent material. Compared with the prior art, the preparation method of the fluorescent material based on organic and inorganic hybrid perovskite quantum dots has the advantages that the silica sol is used for wrapping the organic and inorganic hybrid perovskite quantum dots, the organic amines compound is added in the silica sol to inhibit decomposition of the quantum dots in a sol-gel conversion process, doping of the quantum dots in silicon dioxide glass is realized, due to double effects of silicon dioxide and the organic amines compound, light, thermal, water and oxygen stability of the fluorescent material can be greatly improved, and thus, thefeasibility of the fluorescent material in actual application is improved.

The invention relates to a rare earth doped gadolinium-potassium fluoride nanometer material for a magneto-optical double-module biological marker and a preparation method thereof. The preparation method comprises the following steps of: mixing gadolinium chloride, potassium chloride and ammonium fluoride in distilled water, ethanol and ethanediol by utilizing propylene imine as a surface active agent; carrying out hydro-thermal treatment at 50-230 DEG C for a period of time; washing, and drying to obtain a DGdF4:Ln nanometer crystal, wherein the commonest of the DGdF4:Ln nanometer crystal are as follows: xLn3+-(1-x)KGdF4 (Ln=Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm, Yb; x=0-60 mol%). The rare earth doped DGdF4 nanometer fluorescence marker material prepared by adopting the method can not only control the size of nanometer granules at about 25 nanometers, but also has better water solubility, can utilize the amino on the surface to be connected with biological molecules; besides, the biological connection is subjected to hypersensitivity detection by realizing needed specific fluorescence emission in such a way that different rare earth ions are doped in the nanometer granules, namely the rare earth doped DGdF4 nanometer fluorescence marker material obtained through the preparation method has potential in being applied in the field of biological markers; and because gadolinium ions are contained in a matrix, the DGdF4 nanometer crystal can be further used as a T1 magnetic resonance imaging contrast agent.

The invention discloses a beta-phenanthrene azaBODIPY dye and a preparation method and application thereof. The structural formula of the beta-phenanthrene azaBODIPY dye is as shown in the formula (I) (please see the formula in the description), wherein R1 is alkoxy groups of C1-C6, R2 and R4 are independently selected from alkoxy groups of C1-C6 or alkyl groups of C1-C6, and R3 and R5 are independently selected from hydrogen or alkoxy groups of C1-C6. By means of the design, the prepared beta-phenanthrene azaBODIPY dye of the structure shown in the formula (I) has large absorption wavelength in actual use, narrow absorption peaks and emission peaks and excellent molar absorption coefficient, and thereby having potential application in optical sensors and photoacoustic imaging.

An Eu(III)-Fe(II) luminescent nanometer tube, its production and use are disclosed. The structural formula is (Eu(PDA)3Fe1.5(H2O)3).1.5H2O, PDA=2, 6-pyridine diacid ligand. MgC12 is added into N,N'-dimethyl-methane amide solution, transmitting-peak strength is increased with Mg2+ ion concentration increasing. It has stable three-dimensional nanometer tubular structure; it can be used as Mg2+ ion fluorescent mark and used for biological molecular discrimination.

The invention discloses a rare earth-doped gadolinium fluoride nano luminous material for time-resolved multi-color fluorescence labeling and a preparation method thereof, and relates to preparation of a multi-color luminous nano material and an application method of the multi-color luminous nano material combining a time-resolved detection mode in the field of biological fluorescence labeling. The component of the prepared gadolinium fluoride nano crystal is xRe3+-(1-x)GdF3 (RE is Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm or Yb; and x is 0 to 60 mol percent). Light of different colors under the excitation of single wavelength is obtained by doping different rare earth ions with different doping concentrations. The light emitted by a sample is detected by using a fluorescence spectroscope, and visible light of different colors can be respectively obtained under the excitation of ultraviolet. By combining the time-resolved detection mode, short-life interference signals can be effectively removed, and the detection sensitivity can be improved.

The invention discloses a suspension type liquid biological chip detection system which comprises an upper cover plate, a front panel, a left panel, a right panel, a back plate, a liquid barrel fixingdevice, a light path system, a liquid path system, a circuit control system and a test tube picking and placing device, wherein a single laser is arranged in the light path system; according to the invention, nanocrystalline fluorescent microspheres are adopted; the emission peak width is relatively narrow; the particle size is controllable; optical coding can be conveniently carried out by usingdifferent wavelengths and microsphere particle sizes; classified fluorescence in the nanocrystalline fluorescent microspheres and labeled fluorescence of molecules to be detected in a sample are excited by using a single laser, a plurality of detection channels can be provided by the method, a larger number of information codes can be obtained, and the detection cost is greatly reduced by using asingle laser for excitation.

The invention provides a preparation method of an ethylene diamine functionalized carbon quantum dot and application thereof in catechol detection. Ethylene diamine is introduced to the surfaces of the carbon quantum dot through amidation reaction and a protection/de-protection method to synthesize the ethylene diamine functionalized carbon quantum dot, the preparation process is simple, the raw material source is wide, the price is low, and the obtained compound has a target detection substance selective binding function. In a neutral environment, catechol can quickly react with ethylene diamine on the surface of the ethylene diamine functionalized carbon quantum dot to generate a static compound, and the static compound causes synchronous quenching of nuclear-state and surface-state fluorescence of the ethylene diamine functionalized carbon quantum dot. The catechol concentration and the fluorescence quenching value of the ethylene diamine functionalized carbon quantum dot have a good linear relationship, and the detection limit reaches 0.07 mg/L. According to the invention, a simple and rapid catechol fluorescence quantitative analysis method is established, and has extremely high selectivity and interference resistance for catechol detection.

The invention provides a Tm and Eu mono/co-doped lutecium gallium garnet phosphor. The chemical formula of the phosphor is Lu(3-x-y)Ga5O12:xEu<3+>, yTm<3+>, wherein x is 0-0.04, y is 0-0.02, and x and y cannot be zero simultaneously. Uniform ion mixing is realized through a low temperature combustion method, and the prepared phosphor has the characteristics of spumous and loose structure, no clustering, easy ball milling and high purity. The method has the characteristics of substantial reduction of the furnace temperature, and simple production process, and is an efficient energy-saving synthesis method. The obtained phosphor has a narrow emission peak, has a peak width at half height of 4-5nm, and emits different-color light under the excitation of 241nm light, red light is emitted when only Eu<3+> is doped, blue light is emitted when only Tm<3+> is doped, white light is emitted when Eu<3+> and Tm<3+> are codoped, the phosphor can be compounded with an ultraviolet LED chip to realize white light emission.

The invention discloses a turn-on type test strip for detecting T-2 toxin and a preparation method of the turn-on type test strip, and belongs to the technical field of rapid food detection. The test strip consists of a bottom plate, a sample pad, an absorption pad and a nitrocellulose membrane (NC membrane). The method comprises the following steps: time-resolved fluorescent microspheres is selected as a fluorescent material, the time-resolved fluorescent microspheres is coupled with BSA (Bovine Serum Albumin), and a prepared compound is fixed on a test strip to serve as a fluorescent donor; a colloidal carbon labeled antibody compound is used as a quencher, a mixture of a time-resolved fluorescent microsphere labeled BSA bovine serum albumin compound and a T-2 antigen is sprayed on an NC membrane to serve as a detection line, a goat anti-mouse IgG antibody is sprayed to serve as a quality control line, and the turn-on type lateral flow chromatography detection test strip is assembled. The test strip can be used for on-site detection of T-2 toxin, increases the detection sensitivity and the detection speed, is suitable for large-scale application and batch production, and has good application and development prospects.