Rare earth-doped gadolinium fluoride nano luminous material for time-resolved multi-color fluorescence labeling and preparation method thereof

A nano-luminescent material and rare earth doping technology, which is applied in the direction of luminescent materials, fluorescence/phosphorescence, chemical instruments and methods, etc., to achieve the effect of small size, narrow emission peak, and uniform particles

Active Publication Date: 2011-08-03
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are no examples of combining time-resolved bioluminescent labeling with rare earth-doped nanocrystals.

Method used

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  • Rare earth-doped gadolinium fluoride nano luminous material for time-resolved multi-color fluorescence labeling and preparation method thereof
  • Rare earth-doped gadolinium fluoride nano luminous material for time-resolved multi-color fluorescence labeling and preparation method thereof
  • Rare earth-doped gadolinium fluoride nano luminous material for time-resolved multi-color fluorescence labeling and preparation method thereof

Examples

Experimental program
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Effect test

example 1

[0017] Example 1: Take by weighing 0.0037g europium chloride (EuCl 3 ·6H 2 O) and 0.37g gadolinium chloride (GdCl 3 ·6H 2 O) be completely dissolved in 12 milliliters of distilled water, then add 1 milliliter of ethanol and 30 milliliters of ethylene glycol, stir to obtain a transparent solution; in another beaker, an appropriate amount of ammonium fluoride is dissolved in 0.5 milliliters of distilled water, then add 2.5 milliliters of ethanol, Stir to obtain a transparent solution B; under stirring, add solution A dropwise to solution B, continue stirring for ten minutes, transfer the solution into a hydrothermal tank, and perform hydrothermal treatment at 170°C for 20 hours. After cooling, clarify the upper layer The liquid was removed, and the lower precipitate was washed with water and ethanol three times in turn, dried, and then dried under vacuum at 60°C to obtain Eu:GdF 3 nanocrystalline powder. 10 mg Eu:GdF 3 Nanocrystalline powder is dissolved in 20 ml of distill...

example 2

[0018] Example 2: Take by weighing 0.0037g terbium chloride (TbCl 3 ·6H 2 O) and 0.37g gadolinium chloride (GdCl 3 ·6H 2 O) be completely dissolved in 5 milliliters of distilled water, then add 30 milliliters of ethanol and 5 milliliters of ethylene glycol, stir to obtain a transparent solution; in another beaker, an appropriate amount of ammonium fluoride is dissolved in 1 milliliter of distilled water, then add 1 milliliter of ethanol, Stir to obtain a transparent solution B; under stirring, add solution A dropwise to solution B, continue stirring for ten minutes, transfer the solution into a hydrothermal tank, and perform hydrothermal treatment at 110°C for 18 hours. After cooling, clarify the upper layer The liquid was removed, and the lower precipitate was washed with water and ethanol three times in turn, dried, and then dried under vacuum at 50°C to obtain Tb:GdF 3 nanocrystalline powder. 2 mg Tb:GdF 3 The nanocrystalline powder is dissolved in 20 ml of distilled w...

example 3

[0019] Example 3: Take by weighing 0.0037g dysprosium chloride (DyCl 3 ·6H 2 O) and 0.37g gadolinium chloride (GdCl 3 ·6H 2 O) Dissolve completely in 2 milliliters of distilled water, then add 30 milliliters of ethylene glycol, and stir to obtain a transparent solution; in another beaker, dissolve an appropriate amount of ammonium fluoride in 5 milliliters of distilled water, then add 1 milliliter of ethanol, and stir to obtain a transparent solution B; in a stirring state, add solution A dropwise to solution B, continue to stir for ten minutes, transfer the solution into a hydrothermal tank, and perform hydrothermal treatment at 140°C for 24 hours. After cooling, remove the supernatant liquid, and The lower precipitate was washed with water and ethanol three times in turn, dried, and then dried under vacuum at 65°C to obtain Dy:GdF 3 nanocrystalline powder. 15 mg Dy:GdF 3 The nanocrystalline powder is dissolved in 20 ml of distilled water to obtain Dy:GdF 3 Colorless an...

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Abstract

The invention discloses a rare earth-doped gadolinium fluoride nano luminous material for time-resolved multi-color fluorescence labeling and a preparation method thereof, and relates to preparation of a multi-color luminous nano material and an application method of the multi-color luminous nano material combining a time-resolved detection mode in the field of biological fluorescence labeling. The component of the prepared gadolinium fluoride nano crystal is xRe3+-(1-x)GdF3 (RE is Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm or Yb; and x is 0 to 60 mol percent). Light of different colors under the excitation of single wavelength is obtained by doping different rare earth ions with different doping concentrations. The light emitted by a sample is detected by using a fluorescence spectroscope, and visible light of different colors can be respectively obtained under the excitation of ultraviolet. By combining the time-resolved detection mode, short-life interference signals can be effectively removed, and the detection sensitivity can be improved.

Description

technical field [0001] The invention relates to a time-resolved multicolor fluorescent labeling material, in particular to the preparation of a variety of rare earth element-doped gadolinium fluoride nanometer multicolor luminescent materials and their application in the field of biological fluorescence in combination with a time-resolved detection mode. Background technique [0002] Multicolor luminescent materials excited by a single wavelength have broad application prospects in optoelectronic devices, liquid crystal displays, biomedical imaging, etc., and have attracted widespread attention from domestic and foreign scholars. The currently used multicolor luminescent materials are mainly organic luminescent dyes and quantum dots. However, organic dyes have weaknesses such as photobleaching, broad emission peaks, and impurity in light and chromaticity; while quantum dots are highly toxic and expensive to synthesize, which limits their application. Rare-earth-doped nanocr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85G01N21/64
Inventor 陈学元鞠强李仁富朱浩淼
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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