104 results about "Gadolinium chloride" patented technology

This invention relates to a chelated calcium fertilizer, which is prepared from: catalyst 1-2 wt. %, inorganic calcium raw material 58-69 wt. %, and chelating agent 30-40 wt. %. The chelating agent is composed of: oxalic acid 5-10 wt.%, malic acid 8-20 wt.%, citric acid 15-25 wt.%, maleic acid 10-25 wt.%, sorbitol 3-8 wt.%, gallic acid 8-10 wt.%, and lactic acid 2-8 wt.%. The catalyst is composed of: gadolinium chloride 0.1-0.35 wt.%, selenium dioxide 0.1-0.2 wt.%, chalcanthite 0.05-0.1 wt.%, KOH 0.05-0.1 wt.%, potash 0.1-0.2 wt.%, and palladium carbonate 0.05-0.2 wt.%. The chelating agent has appropriate stability and low cost, and can chelate with calcium in solid state. Besides, the chelating agent cannot be deactivated in plants by hydrolysis or reacting with phosphate, sulfate and oxalic acid. This invention also relates to a method for preparing the chelated calcium fertilizer, which specifies the production process, process parameters, and chelating agent and high-efficiency catalyst needed.

The invention belongs to the technical field of biotechnology, and relates to a tumor-targeted diagnosis nuclear magnetic resonance contrast agent and a preparation method thereof. The tumor-target diagnosis nuclear magnetic resonance contrast agent is prepared from a high molecular material, polyethylene glycol, a polypeptide, a dual-function ligand and gadolinium chloride by taking the polypeptide as a target head group, taking the tree-like high polymer material as a basic high molecular vector and connecting a small molecular contrast agent to the surface. In the invention, a polypeptide-modified high molecular material screened by using a phage display technology enters cells in an endocytic way, so that the introjection of the contrast agent by tumor cells is increased, and the characteristic of high safety is achieved. The target head group polypeptide used in the invention has the advantages of transferrin, can be used for effectively avoiding the interference of endogenous transferrin, has high targeting and diagnosing efficiencies, is simple to prepare, and can be further applied to target diagnosis of other tumor tissues.

This invention relates to a chelated zinc fertilizer, which is prepared from: catalyst 1-2 wt. %, inorganic zinc raw material 58-69 wt. %, and chelating agent 30-40 wt. %. The chelating agent is composed of: oxalic acid 5-10 wt.%, malic acid 8-20 wt.%, citric acid 15-25 wt.%, maleic acid 10-25 wt.%, sorbitol 3-8 wt.%, gallic acid 8-10 wt.%, and lactic acid 2-8 wt.%. The catalyst is composed of: gadolinium chloride 0.1-0.35 wt.%, selenium dioxide 0.1-0.2 wt.%, chalcanthite 0.05-0.1 wt.%, KOH 0.05-0.1 wt.%, potash 0.1-0.2 wt.%, and palladium carbonate 0.05-0.2 wt.%. The chelating agent has appropriate stability and low cost, and can chelate with zinc in solid state. This invention also relates to a method for preparing the chelated zinc fertilizer, which specifies the process parameters, and appropriate catalyst and reaction conditions.

The invention discloses an active targeting polymer nanoparticle magnetic resonance contrast agent and a preparation method thereof. The magnetic resonance contrast agent is prepared by chelating nanoparticles of a diethylenetriamine pentaacetic acid-polylysine-polyethylene glycol-polylactic acid copolymer and gadolinium chloride (GdCl3) and connecting a plurality of amino groups of the polylysine and a targeting factor; the structural formula of the diethylenetriamine pentaacetic acid-polylysine-polyethylene glycol-polylactic acid copolymer is shown in the specification; and the targeting factor and chelating ions are connected to the amino groups of a polylysine segment of the copolymer. The magnetic resonance contrast agent of the invention has a remarkable development enhancing function and active targeting development has the characteristics of specificity, selectivity, remarkable biological effect and the like. Poly lactic acid-polyethylene glycol-phase-locked loop-g-diethylenetriaminepentaacetic acid-Ga (PLA-PEG-PLL-g-DTPA-Gd) nanoparticles are taken as carriers of DTPA-Gd and the local concentration of the contrast at a tumor position is increased and a diagnosis effect is enhanced through an active targeting function, toxic and side effects are reduced and the aim of active targeting development is fulfilled.

The invention belongs to the technical field of low-temperature magnetic refrigeration materials and relates to an inorganic-organic hybrid gadolinium-based molecular-based low-temperature magnetic refrigeration material and a preparation method thereof. By assembly study on hypophosphorous acid as an inorganic ligand, oxalic acid as an organic ligand and gadolinium chloride, the inorganic-organic hybrid gadolinium-based molecular-based low-temperature magnetic refrigeration material is prepared. A molecular formula of the prepared low-temperature magnetic refrigeration material is [Gd(C2O4)(H2PO2)(H2O)2], the molecular weight is 346.29, crystallographic data is described in the description, Z is equal to 4, and a space group is P21/n. The inorganic-organic hybrid gadolinium-based molecular-based low-temperature magnetic refrigeration material and the preparation method thereof are simple and available in raw materials, simple in method, convenient to operate and good in repeatability.

The invention discloses a production process of high-purity gadolinium oxide by acidic phosphorus type extracting agent. In a P507-kerosene-HCl system of the production process, solvent extraction is adopted to separate and purify rare earth chloride solution rich in gadolinium into high-purity gadolinium chloride solution by utilizing the variation of extraction rate and distribution ratio and the difference of separation factor of saponification acidic phosphorus type extracting agent P507 on rare earth element to obtain gadolinium oxide product of 99.995%. The process adopts extracting agent purification technology and rare earth exchanging purification washing technology, therefore, the consumption of raw materials is low, the quality of products is stable, and the indicators of various rare-earth and non-rare earth impurities are far superior to congeneric products in the national standard.

The invention relates to a rare earth doped gadolinium-potassium fluoride nanometer material for a magneto-optical double-module biological marker and a preparation method thereof. The preparation method comprises the following steps of: mixing gadolinium chloride, potassium chloride and ammonium fluoride in distilled water, ethanol and ethanediol by utilizing propylene imine as a surface active agent; carrying out hydro-thermal treatment at 50-230 DEG C for a period of time; washing, and drying to obtain a DGdF4:Ln nanometer crystal, wherein the commonest of the DGdF4:Ln nanometer crystal are as follows: xLn3+-(1-x)KGdF4 (Ln=Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm, Yb; x=0-60 mol%). The rare earth doped DGdF4 nanometer fluorescence marker material prepared by adopting the method can not only control the size of nanometer granules at about 25 nanometers, but also has better water solubility, can utilize the amino on the surface to be connected with biological molecules; besides, the biological connection is subjected to hypersensitivity detection by realizing needed specific fluorescence emission in such a way that different rare earth ions are doped in the nanometer granules, namely the rare earth doped DGdF4 nanometer fluorescence marker material obtained through the preparation method has potential in being applied in the field of biological markers; and because gadolinium ions are contained in a matrix, the DGdF4 nanometer crystal can be further used as a T1 magnetic resonance imaging contrast agent.

The invention discloses a polymer nanoparticle magnetic resonance contrast agent which is prepared by the chelation of diethylenetriamine pentaacetic acid-polyethyleneglycol-polylactic acid polymer nanoparticle and gadolinium chloride GdCl3. The structural formula is showed as right, wherein m and n are integers. The molecular weight of the diethylenetriamine pentaacetic acid-polyethyleneglycol-polylactic acid polymer nanoparticle is from 10000 to 50000. The polymer nanoparticle magnetic resonance contrast agent has obvious development increase function, realizes targeting development by the property of PLA-PEG-DTPA-Gd nanoparticle, is a passive targeting administration system, and has the characteristics of specificity, selectivity, obvious biological effect, and the like. Taking the PLA-PEG nanoparticle as a carrier of DTPA-Gd, the contrast agent increases the local concentration of medicine on liver, enhances the curative effect, reduces toxic and side effect and achieves the purpose of targeting development.

The invention provides a Gd<3+>-induced self-assembly method of gold nanoclusters for forming gold nanoparticles and applications of the gold nanoparticles. The Gd<3+>-induced self-assembly method comprises the following steps: a preparation step of the gold nanoclusters, specifically comprising the following substeps: preparing the gold nanoclusters by adopting chiral L-form glutathione as a sulfydryl ligand, and dissolving the gold nanoclusters in deionized water, thus forming a solution A; a preparation step of trivalent gadolinium ions Gd<3+>, specifically comprising the following substeps: dissolving gadolinium chloride hexahydrate in deionized water, thus preparing a solution B, and carrying out ultrasonic treatment for later use; and a Gd<3+>-induced self-assembly step of the gold nanoclusters, specifically comprising the following substeps: dropwise adding the solution B into the solution A slowly, and inducing the gold nanoclusters to form the gold nanoparticles through self-assembly. The method is simple, the material synthesis cost is low, the reaction conditions are simple, the operation is easy, the prepared gold nanoparticles have the enhanced fluorescence imaging and CT imaging effects, Gd<3+> is chelated, and the gold nanoparticles can be taken as a nuclear magnetic imaging contrast agent of tumor. The experiment result shows that the prepared gold nanoparticles can be well applied to the field of multi-modal imaging of the tumor.

The invention relates to the technical field of chemical engineering and particularly discloses a fluorescent substance based on an amino acid deep eutectic solvent and a preparation method of the fluorescent substance. The fluorescent substance based on the amino acid deep eutectic solvent comprises the following ingredients: the deep eutectic solvent and rare earth chloride at a mass ratio of (10-20):1, wherein rare earth chloride is at least one of europium chloride, lanthanum chloride, terbium chloride or gadolinium chloride; and the deep eutectic solvent comprises an alcohol compound andamino acid at a mole ratio of (5-10):1. The fluorescent substance based on the amino acid deep eutectic solvent can achieve a uniform luminescence effect, and is good in heat stability, green and environmentally friendly.

The invention discloses a preparation process for controlling the specific surface area of rare earth oxide and relates to the technical field of chemistry. The preparation process comprises the following steps: dissolving gadolinium oxide into a gadolinium chloride solution with the concentration of 1.0M/L by utilizing hydrochloric acid; dissolving industrial oxalic acid with de-ionized water until the concentration is 15 percent and filtering to obtain a precipitant; adding a quarter volume of de-ionized water at 20 DEG C to 25 DEG C into a reaction kettle; adding material liquid and the precipitant and ageing for one hour; after precipitating, pumping away supernatant; unloading sediment into a washing barrel; after continuously washing for a plurality of times, dispersing the sediment into absolute ethyl alcohol and carrying out ultrasonic oscillation for half an hour; carrying out solid-liquid separation by utilizing a centrifugal machine and calcining to obtain a gadolinium oxide product. The specific surface area range of the product is 3m<2>/g to 5m<2>/g and accords with original expectation. The method has a simple process and low cost and the prepared rare earth oxide has a large specific surface area and more stable properties and is suitable for popularization.

An improved method of treating periodontitis includes the steps of: creating a formulation containing a lanthanide-containing protease inhibitor; and applying the formulation to a periodontal area. The lanthanide may be cerium chloride, samarium chloride, lutetium chloride, cerium chloride heptahydrate, lutetium chloride hexahydrate, samarium chloride hexahydrate, gadolinium, gadolinium nitrate, gadolinium chloride, gadolinium chloride hexahydrate and gadolinium nitrate hexahydrate. The invention also provides an improved method of reducing dentinal sensitivity, including the steps of: creating a formulation containing at least one of gadolinium and a gadolinium-containing compound; and applying the formulation to a sensitive dentinal area. The formulation may be a paste, a solution or a powder.

The invention discloses a preparation method of nano gadolinium oxide with the grain size being 80-100nm. The preparation method comprises the following steps that a sodium bicarbonate solution with the concentration being 0.1mol/L-0.6mol/L and the temperature being 0-5 DEG C is added dropwise into a gadolinium chloride containing polyethylene glycol 10000 and/or polyethylene glycol 20000 at the speed of 3-6L/min, the mixed solution is continuously stirred for 0.5-1 hour after dropwise adding is completed, and then subjected to standing and ageing at the temperature of 0-5 DEG C, a mother solution containing sediment is prepared, wherein the temperature of the reaction system in the process is 0-5 DEG C, the operation environment temperature is maintained to be 26-28 DEG C, filtration andwashing are conducted then, the filtration washing means is that the product is dipped and washed in hot pure water with the temperature being 95 DEG C or above for a plurality of times, the filter cake after filtration and washing is placed for 24 hours or above at the temperature of 0-5 DEG C, and then burned for 1-2 hours at the temperature of 800-850 DEG C, and the nano gadolinium oxide with the grain size being 80-100nm is prepared.

The invention provides a catalyst for production of tert-butylamine as well as a preparation method and an application of the catalyst. A fluorine-modified Ni-containing hydrotalcite-like compound adopting a mesoporous structure is taken as a carrier, after activation by vapor, the hydrotalcite-like compound is used for carrying gadolinium chloride and/or praseodymium chloride with a liquid phase sedimentation method, and then the catalyst product is produced through drying. The specific aperture and the shape selectivity of the catalyst product are very effective on inhibiting side reactions, and the carried gadolinium chloride/praseodymium chloride provides L acidic active sites for the catalyst. Under the low pressure condition, the higher isobutylene conversion per pass can also be maintained if the catalyst is applied to a reaction for preparing the tert-butylamine through direct amination of isobutylene and ammonia, the catalyst can still keep higher activity after long-term operations, and the service life of the catalyst can be prolonged.

The invention relates to a method for preparing a reduction-sensitive medicine nano-agent for diagnoses and treatment through single-walled carbon nanotubes modified through hyaluronic acid and application of the method. The method can effectively solve the problems that tumor targeting of the anti-cancer drug adriamycin is poor, toxic and side effects are large, targeting is poor, relaxivity is low and the half-life period is short. According to a transport system, the single-walled carbon nanotubes modified through the hyaluronic acid are connected with the adriamycin through 3,3'-dithio-thiodipropionic acid serving as a joint arm, then gadolinium chloride is adsorbed to the single-walled carbon nanotubes, and the single-walled carbon nanotubes modified through the hyaluronic acid are formed through dispersion of a surface active agent. The reduction-sensitive medicine nano-agent used for diagnoses and treatment has the advantages that biocompatibility and tumor targeting are good, thermal therapy and chemotherapy are combined, and diagnosis and treatment are combined, is an innovation of tumor diagnosis and treatment medicine, and is large in economic and social benefit.

The invention discloses a preparation method of a gadolinium doped rare earth europium complex. The method is as below: preparing europium oxide and gadolinium oxide into europium chloride and gadolinium chloride; and conducting a coordination reaction on europium chloride and gadolinium chloride and a ligand to prepare a quaternary dual ligand complex. The complex is doped with cheap and non-luminescence gadolinium, but complex has improved fluorescence intensity, and greatly reduces production costs.

The invention discloses a super-hydrophobic coating with a flame-retardant effect and a preparation method thereof, and relates to the technical field of high polymer materials. The preparation methodcomprises the steps: treating cholesterol with succinic anhydride and thionyl chloride, to obtain pretreated cholesterol, carrying out a mixing reaction on the pretreated cholesterol with glucan, toobtain modified glucan; mixing the modified glucan with polylactic acid; dialyzing in water, a gadolinium chloride solution and an ammonium polyphosphate solution in sequence to obtain flame-retardantmicrospheres, calcining the graphene oxide and silicon dioxide together, and etching with hydrofluoric acid to obtain modified graphene; and mixing and grinding the modified graphene and modified glucan, and mixing with a silicone acrylic emulsion and a dispersing agent to obtain the super-hydrophobic coating with flame-retardant effect. The prepared super-hydrophobic coating with the flame-retardant effect has excellent flame retardance and hydrophobicity.

The invention provides nano titanium dioxide for improving the performance of 3D printing consumables and a preparation method thereof. The method of the present invention comprises the following steps: (1) preparing solution A: drop butyl titanate into absolute ethanol while stirring, then add glacial acetic acid, and stir for 0.5-1 hour; (2) prepare solution B: stir Drop the chlorides of gadolinium and praseodymium into absolute ethanol respectively, then add glacial acetic acid and stir for 0.5-1 hour; (3) slowly pour solution B into solution A to make a gel; (4) form (5) Dry the aged gel in an oven to form granules; (6) Grind the dried granules in a mortar and put them in a box-type resistance furnace , carbonized for half an hour, and continued to heat up to 600-800°C for calcination to obtain nano-titanium dioxide powder for improving the performance of 3D printing consumables. The present invention over TiO ₂ The photocatalytic degradation performance of the material improves the product performance of 3D printing consumables and reduces the harmful gas generated during the printing process.

The invention discloses a high-fastness suit fabric dyeing process and relates to pure wool fabrics. The high-fastness suit fabric dyeing process comprises the following steps of S1, pretreatment, S2,dyeing including heating reactive dye solution to 76-82 DEG C and holding the temperature for 50-60 min, then adding in ammonium hydroxide to regulate the PH to 8-9 for treatment for 10-20 min, thencooling down to 50-60 DEG C, adjusting the PH to 4.5-5 for treatment for 8-10 min, and sequentially performing cold water washing, soaping, cold water washing and drying, wherein the active dye solution is composed of, on weight the fabric, 2-3% of reactive dyes, 2-3% of acetic acid, 1-2% of low-temperature additives, 2-3% of ammonium sulfate and 0.1-0.2% of gadolinium chloride, S3, fixation including immersing the dyed fabric into dye-fixing solution at 40-60 DEG C for treatment for 12-25 min, wherein the dye-fixing solution is composed of, on weight the fabric, 2-4% of dye-fixing agent, andS4, cleaning. During the dyeing process, gadolinium ions can be complexed with amino and carboxyl of wool fiber as well carboxyl and amino of dye macromolecules to improve the dye uptake as well as the wool dyeing fastness and the mechanical performance.

The invention discloses a process for producing high-purity gadolinium chloride through fuzzy linkage extraction separation. The process consists of three production lines, namely a Sm/Gd separation line, a Sm/Eu separation line and a Eu/Gd separation line. The process comprises the following steps: pretreating a (SmEuGd)Cl3 feed liquid through the Sm/Gd separation line, and separating Sm from Gd; allowing the (SmEu)Cl3 feed liquid at an extraction outlet of the Sm/Gd separation line to enter the Sm/Eu separation line, allowing (EuGd)A3 feed liquid at an organic outlet of the Sm/Gd separation line to enter the Eu/Gd separation line, connecting the Sm/Eu separation line and the Eu/Gd separation line in series to respectively obtain a SmCl3 product, a feed liquid product of which the Eu percent is more than 50 percent and a GdCl3 product with the purity of 99.99 percent. The process is low in investment and low in acid-base operating consumption, the acid-base consumption can be reduced by over 15 percent, the rare earth rolling groove amount is reduced by over 15 percent, the product quality stability is improved, and the field staff operation is simple.

The invention discloses a synthesis method of a carbon-embedded gadolinium nano magnetic resonance imaging contrast agent. The carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is prepared through a hydrothermal synthesis method. The synthesis method comprises the following steps: (1) adding gadolinium chloride and citric acid into water, ultrasonically dissolving gadolinium chloride and citric acid, and then adding ethidene diamine to obtain a mixed solution; (2) heating and reacting the mixed solution for 4 hours at the temperature of 200 DEG C to obtain a reaction solution; (3) centrifuging, dialyzing and freeze-drying the reaction solution to obtain a target object, wherein the prepared carbon-embedded gadolinium nano magnetic resonance imaging contrast agent serves as a marker, a developer or a tracer agent and is used for in-vivo imaging in an organism to realize detection and diagnosis of diseases. The method has the advantages that the carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is prepared through the hydrothermal synthesis method, and the method is simple in process, easy to implement and low in cost; the carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is good in biocompatibility, good in water solubility, and excellent in fluorescence and nuclear magnetic resonance properties, and serves as the marker, the developer or the tracer agent in the field of biology to realize the detection and the diagnosis of the diseases through biological imaging.

The invention belongs to the technical field of semiconductor nano-material preparation and medical material, and relates to a fluorescent quantum dot used for a magnetic resonance contrast agent and a preparation method thereof. A concrete structure of the quantum dot is Gd@Ag2S, the preparation method comprises the following steps: dissolving silver acetate gadolinium chloride and oleic acid and cetyl mercaptan in octadecene, heating to 50-120 DEG C, then injecting a thioalcohol solution of sulfur, and keeping for 20 minutes. The prepared quantum dot has double functions, can be used for a magnetic resonance imaging contrast agent, and has fluorescence property capable of being adjusted at a near infrared wave band, and has the characteristics of low toxicity and high stability, and the preparation method has the advantages of simple operation and environmental protection.

The invention provides a rare-earth double-doped functional nanocomposite material and a preparation method thereof. The method comprises the process that a sodium hydroxide solution is added into a rare earth ion solution containing gadolinium chloride, europium chloride and terbium chloride; stirring reaction is performed to obtain a colloidal transparent solution; the solvents of the rare earthion solution and the sodium hydroxide solution are polylol, so that the colloidal transparent solution and coating liquid react under heating condition; transparent suspension with a core-shell structure is obtained; the coating liquid contains 3-aminopropyl triethoxysilane, tetraethyl orthosilicate, water, triethylamine and polylol; impurities in the transparent suspension with the core-shell structure are removed; vacuum drying is performed; then, calcination is performed to obtain a product. Tb<3+> and Eu<3+> lanthanide ions are doped into a Gd2O3 substrate; crystal nucleuses are subjectedto organic polysiloxane layer coating; the problem of low Gd2O3 single-doped fluorescence intensity is solved; the biocompatibility of the material is also improved; the fluorescence lifetime is prolonged.