54 results about "Molecular vector" patented technology

FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

Provided herein are antibody molecules that bind specifically to Colony Stimulating Factor 1 Receptor (CSF1R) and related nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

The present invention relates to peptides that bind with high specificity and which functionally interact with the transferrin receptor (“TfR”) and which may be used in making molecular vehicles that carry biomolecules across membranes, including, e.g., across the blood brain barrier or the gastrointestinal tract. TfR specific binding moieties may also be used alone or as components in specific molecules that target the transferrin / transferrin receptor transport system. The invention relates more specifically to VNAR single chain antibodies derived from nurse shark that bind to TfR, compounds and compositions comprising a TfR specific VNAR binding moiety, methods for preparing them, diagnostic and therapeutic methods of use in vitro or in vivo, e.g., to diagnose, treat and / or prevent a pathological condition, disorder or disease in which it is beneficial to deliver a heterologous biomolecule across the blood brain barrier by association with a TfR specific VNAR binding moiety. Other uses for TfR specific VNAR binding moieties of the invention include, e.g., regulating the interaction of iron-charged transferrin with TfR (receptor cycling or cell surface presentation), such as may be therapeutic in treatment of certain cancer cells and tumors of various tissue types.

The invention relates to a molecular vector for single molecule detection. The molecular vector comprises a substrate and a metal layer, wherein one surface of the substrate is provided with a plurality of three-dimensional nanostructures; the three-dimensional nanostructures are respectively arranged along a first direction and a second direction at intervals; and the metal layer is coated on the surface of the three-dimensional nanostructures and on the surface of the substrate between adjacent three-dimensional nanostructures.

The disclosure relates to a carrier for use in single molecule detection. The carrier includes a flexible substrate and a metal layer on the flexible substrate. The flexible substrate includes a base and a bulge pattern located on a surface of the base. The bulge pattern includes a number of strip-shaped bulges intersecting with each other to form a net and define a number of recesses. The metal layer is located on the bulge pattern. The carrier for use in single molecule detection has a relative higher SERS and can enhance the Raman scattering.

The present invention relates to a recombinant spore preparation method in which the bacillus subtilis spore surface displays the lipase with catalytic activity. The method includes: taking the bacillus subtilis spore capsid protein gene as molecular carrier to recombine with lipase gene having triglyceride hydrolysis and transesterification function, constructing amalgamation expressed integrated recombinant plasmid, and transforming the bacillus subtilis to obtain the recombinant strain, induce the spore surface produced by the recombinant strain to display the recombinant spore of the lipase. Compared with the known method in this field, the present inventive method displays lipases with triglyceride hydrolysis function from different sources on the surface of Bacillus subtilis spores,uses the unique resistance of the spores to increase the catalytic activity and stability of lipases.

The invention belongs to the field of pharmacy, and relates to an o-phthalic dihydroxy polymer carrier capable of reversibly combining with a drug, a drug-polymer complex formed by the polymer carrier and a drug, and a drug-delivery drug constructed by the drug-polymer complex system. The o-phthalic dihydroxy polymer carrier prepared by the present invention can be reversibly combined with drugs to form a drug-polymer complex and a nanoparticle drug delivery system, which has the significant advantage of high drug loading, can reduce drug toxicity, improve drug stability, The purpose of improving the in vivo targeting of drugs and enhancing drug efficacy, the experimental results show that: the drug-polymer complex and its nanoparticle drug delivery system has the characteristics of pH-responsive drug release, which can significantly reduce drug toxicity and improve drug efficiency. The stability of the drug can exert passive targeting in vivo or active targeting after further modification of the target molecule, which can significantly improve the efficacy of the drug. It has a good clinical application prospect.

The invention belongs to the field of pharmacy, and relates to a multi-purpose targeting molecule, and applications of a compound and a drug delivery system modified by the multi-purpose targeting molecule in brain tumor diagnosis and treatment. According to the invention, the multi-purpose targeting molecule RGD-pHA being compatible to brain capillary endothelial cells and crossing the blood-brain barrier, being highly compatible to integrin and crossing the blood-brain tumor barrier, and targeting to the brain tumor cells is prepared by adopting a molecule splicing method; the invention further relates to preparation of fluorescein and a medicine modified by RGD-pHA, and a macromolecular carrier material, and applications of RGD-pHA in construction of the drug delivery system. The experimental result shows that the RGD-pHA can be specifically taken by brain capillary endothelial cells expressing the dopamine receptor for mediating the model drug or the nanometer drug delivery system to enter the brain, so that the model drug or the nanometer drug delivery system is specifically taken by the positive cells and the tumor sphere tissue expressing the integrin, the good brain tumor targeting effect is shown in vitro and vivo, and the efficiency in resisting brain tumor is obviously improved.