Fluorescent quantum dot used for magnetic resonance contrast agent and preparation method thereof

A fluorescent quantum dot, quantum dot technology, applied in nuclear magnetic resonance/magnetic resonance imaging contrast agents, chemical instruments and methods, luminescent materials, etc., can solve problems such as unpublished literature reports, and achieve good monodispersity, Simple operation, good cytocompatibility

Inactive Publication Date: 2015-02-04
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since silver and sulfur elements are abundant in nature, and Ag 2 The light-emitting area of ​​S quantum dots is just in the near-infrared region, which can effectively avoid the fluorescence interference of biological tissues, and more importantly, Ag 2 S has the advantages of low toxicity and easy preparation, so Ag 2 S quantum dots as doped hosts are conducive to their application in biomedicine, etc., but there are no public reports on this technology.

Method used

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  • Fluorescent quantum dot used for magnetic resonance contrast agent and preparation method thereof
  • Fluorescent quantum dot used for magnetic resonance contrast agent and preparation method thereof
  • Fluorescent quantum dot used for magnetic resonance contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] First, 5ml of octadecene, 0.1mmol of silver acetate and 0.01mmol of gadolinium chloride, 0.1mmol of oleic acid and 0.1mmol of hexaalkylmercaptan were added to the reaction flask, then the solution was heated to 50°C, and 0.05mmol of elemental sulfur was dissolved in 0.05ml Hexaalkylthiol and quickly injected into the above reaction solution and maintained for 20 minutes to obtain GdAg with a particle size of 1.5 nm and a stoichiometric ratio of Gd:Ag of 1:10 2 S quantum dots.

[0026] Do not change the GdAg in this embodiment 2 S quantum dot preparation raw materials and preparation process, only the solution is heated to 50 ° C to change the solution temperature to 75 ° C, and the stoichiometric ratio of Gd: Ag is 1: 10 to obtain GdAg with a particle size of 2.6 nm. 2 S quantum dots.

[0027] Do not change the GdAg in this embodiment 2 S quantum dot preparation raw materials and preparation process, only the solution is heated up to 50 ° C to change the solution tem...

Embodiment 2

[0031] First, 50ml of octadecene, 1mmol of silver acetate and 0.00625mmol of gadolinium chloride, 1mmol of oleic acid and 1mmol of hexaalkyl mercaptan were added to the reaction flask, then the solution was heated to 75°C, and 0.5mmol of elemental sulfur was dissolved in 0.5ml of hexaalkylsulfur Alcohol and quickly injected into the above reaction solution and kept for 20 minutes to prepare GdAg with a particle size of 2.6 nm and a stoichiometric ratio of Gd:Ag of 1:160 2 S quantum dots.

[0032] Do not change the GdAg in this embodiment 2 S quantum dot preparation raw materials and preparation process, only the amount of gadolinium chloride was changed to 0.00625 × 2mmol, 0.00625 × 4mmol, 0.00625 × 8mmol, 0.00625 × 16mmol respectively, and the stoichiometric ratio Gd:Ag can be obtained respectively 1:160, 1:80, 1:40, 1:20, 1:10 GdAg with a particle size of 2.6nm 2 S quantum dots.

[0033] image 3 It is the elemental analysis result of quantum dots with a particle size of...

Embodiment 3

[0035]First, 20ml of octadecene, 0.4mmol of silver acetate, 0.04mmol of gadolinium chloride, 0.4mmol of oleic acid and 0.4mmol of hexaalkylmercaptan were added to the reaction flask, then the solution was heated to 120°C, and 0.2mmol of elemental sulfur was dissolved in 0.2ml of hexaalkylene mercaptan. In the alkylthiol and quickly injected into the above reaction solution and kept for 20 minutes, the GdAg with a stoichiometric ratio of Gd:Ag of 1:10 and a size of 3.5 nm was obtained. 2 S quantum dots.

[0036] Figure 4 It is the X-ray powder diffraction analysis result of the quantum dots with a particle size of 3.5nm and a stoichiometric ratio (Gd:Ag:S=0.1:1:0.5) prepared in Example 3 at a reaction temperature of 120°C.

[0037] Do not change the GdAg in this embodiment 2 S quantum dot preparation raw materials and preparation process, only change the amount of gadolinium chloride to 0.01mmol, and finally can prepare GdAg with a stoichiometric ratio of Gd:Ag of 1:40 and a...

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Abstract

The invention belongs to the technical field of semiconductor nano-material preparation and medical material, and relates to a fluorescent quantum dot used for a magnetic resonance contrast agent and a preparation method thereof. A concrete structure of the quantum dot is Gd@Ag2S, the preparation method comprises the following steps: dissolving silver acetate gadolinium chloride and oleic acid and cetyl mercaptan in octadecene, heating to 50-120 DEG C, then injecting a thioalcohol solution of sulfur, and keeping for 20 minutes. The prepared quantum dot has double functions, can be used for a magnetic resonance imaging contrast agent, and has fluorescence property capable of being adjusted at a near infrared wave band, and has the characteristics of low toxicity and high stability, and the preparation method has the advantages of simple operation and environmental protection.

Description

technical field [0001] The invention belongs to the technical field of semiconductor nanomaterial preparation and medical materials, and in particular relates to a fluorescent quantum dot which can be used as a magnetic resonance contrast agent and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) technology is an innovative medical imaging diagnosis technology that has gradually developed since the early 1980s. It uses magnetic resonance phenomena to obtain electromagnetic signals from the human body and reconstruct human body information. , because this technology has obvious advantages such as non-invasive diagnosis, high-resolution anatomical imaging and quantitative evaluation of pathogenesis, and MRI detection is relatively safe and can avoid ionization damage to the human body, so it is different from traditional medical imaging technologies, such as CT detection and Compared with nuclear imaging (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/58A61K49/06
Inventor 刘洋盛辉李冬泽解仁国
Owner JILIN UNIV
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