Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent

A technology of magnetic resonance imaging and synthesis method, which is applied in nuclear magnetic resonance/magnetic resonance imaging contrast agent and other directions, can solve the problems of complex synthesis method, expensive reagents, cumbersome and other problems, and achieves the effects of simple process, good biocompatibility and low cost

Inactive Publication Date: 2014-05-21
NANKAI UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the biocompatibility of these probes has improved, the synth...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent
  • Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent
  • Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] A method for synthesizing a carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent, which is prepared by a hydrothermal synthesis method, and the steps are as follows:

[0023] 1) Add 100 mg of gadolinium chloride and 420 mg of citric acid into 10 mL of water, ultrasonically dissolve for 10 min, then add 0.5 mL of ethylenediamine and mix well to obtain a mixture;

[0024] 2) Add the above mixed solution into the polytetrafluoroethylene liner and put it into the reaction kettle, put it in the oven, and heat it at 200 o C under heating reaction 4 hours, obtains reaction solution;

[0025] 3) The above reaction solution was centrifuged, dialyzed and freeze-dried to obtain 30 mg of yellow powder, which was the carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent.

[0026]

[0027] figure 1 The electron microscope image of the prepared carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent, in which: A is the tran...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a synthesis method of a carbon-embedded gadolinium nano magnetic resonance imaging contrast agent. The carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is prepared through a hydrothermal synthesis method. The synthesis method comprises the following steps: (1) adding gadolinium chloride and citric acid into water, ultrasonically dissolving gadolinium chloride and citric acid, and then adding ethidene diamine to obtain a mixed solution; (2) heating and reacting the mixed solution for 4 hours at the temperature of 200 DEG C to obtain a reaction solution; (3) centrifuging, dialyzing and freeze-drying the reaction solution to obtain a target object, wherein the prepared carbon-embedded gadolinium nano magnetic resonance imaging contrast agent serves as a marker, a developer or a tracer agent and is used for in-vivo imaging in an organism to realize detection and diagnosis of diseases. The method has the advantages that the carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is prepared through the hydrothermal synthesis method, and the method is simple in process, easy to implement and low in cost; the carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is good in biocompatibility, good in water solubility, and excellent in fluorescence and nuclear magnetic resonance properties, and serves as the marker, the developer or the tracer agent in the field of biology to realize the detection and the diagnosis of the diseases through biological imaging.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation, in particular to a synthesis method and application of a carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent. Background technique [0002] The development of low toxicity and high biocompatibility imaging probes has received more and more attention in the fields of clinical diagnosis and so on. Among them, nuclear magnetic resonance imaging and fluorescence imaging technology have been greatly developed in the field of biological imaging due to no tissue damage and high imaging effect. Dual-modality imaging probes with NMR and fluorescence are of great interest for scientific research and practical applications. [0003] Currently, MRI contrast agents mainly include gadopentetate meglumine (Gd-DTPA) and gadoterate meglumine (Gd-DOTA). The longitudinal relaxation rate of these nuclear magnetic resonance imaging materials is relatively small, the imaging effect is p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/06
Inventor 尹学博徐阳韦晓密
Owner NANKAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap