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Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent

A technology of magnetic resonance imaging and synthesis method, which is applied in nuclear magnetic resonance/magnetic resonance imaging contrast agent and other directions, can solve the problems of complex synthesis method, expensive reagents, cumbersome and other problems, and achieves the effects of simple process, good biocompatibility and low cost

Inactive Publication Date: 2014-05-21
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the biocompatibility of these probes has improved, the synthesis method is complex and tedious, and the reagents required are expensive

Method used

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  • Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent
  • Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent
  • Synthesis method and application of carbon-embedded gadolinium nano magnetic resonance imaging contrast agent

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Embodiment

[0022] A method for synthesizing a carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent, which is prepared by a hydrothermal synthesis method, and the steps are as follows:

[0023] 1) Add 100 mg of gadolinium chloride and 420 mg of citric acid into 10 mL of water, ultrasonically dissolve for 10 min, then add 0.5 mL of ethylenediamine and mix well to obtain a mixture;

[0024] 2) Add the above mixed solution into the polytetrafluoroethylene liner and put it into the reaction kettle, put it in the oven, and heat it at 200 o C under heating reaction 4 hours, obtains reaction solution;

[0025] 3) The above reaction solution was centrifuged, dialyzed and freeze-dried to obtain 30 mg of yellow powder, which was the carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent.

[0026]

[0027] figure 1 The electron microscope image of the prepared carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent, in which: A is the tran...

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Abstract

The invention discloses a synthesis method of a carbon-embedded gadolinium nano magnetic resonance imaging contrast agent. The carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is prepared through a hydrothermal synthesis method. The synthesis method comprises the following steps: (1) adding gadolinium chloride and citric acid into water, ultrasonically dissolving gadolinium chloride and citric acid, and then adding ethidene diamine to obtain a mixed solution; (2) heating and reacting the mixed solution for 4 hours at the temperature of 200 DEG C to obtain a reaction solution; (3) centrifuging, dialyzing and freeze-drying the reaction solution to obtain a target object, wherein the prepared carbon-embedded gadolinium nano magnetic resonance imaging contrast agent serves as a marker, a developer or a tracer agent and is used for in-vivo imaging in an organism to realize detection and diagnosis of diseases. The method has the advantages that the carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is prepared through the hydrothermal synthesis method, and the method is simple in process, easy to implement and low in cost; the carbon-embedded gadolinium nano magnetic resonance imaging contrast agent is good in biocompatibility, good in water solubility, and excellent in fluorescence and nuclear magnetic resonance properties, and serves as the marker, the developer or the tracer agent in the field of biology to realize the detection and the diagnosis of the diseases through biological imaging.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation, in particular to a synthesis method and application of a carbon-embedded gadolinium nano-magnetic resonance imaging contrast agent. Background technique [0002] The development of low toxicity and high biocompatibility imaging probes has received more and more attention in the fields of clinical diagnosis and so on. Among them, nuclear magnetic resonance imaging and fluorescence imaging technology have been greatly developed in the field of biological imaging due to no tissue damage and high imaging effect. Dual-modality imaging probes with NMR and fluorescence are of great interest for scientific research and practical applications. [0003] Currently, MRI contrast agents mainly include gadopentetate meglumine (Gd-DTPA) and gadoterate meglumine (Gd-DOTA). The longitudinal relaxation rate of these nuclear magnetic resonance imaging materials is relatively small, the imaging effect is p...

Claims

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Application Information

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IPC IPC(8): A61K49/06
Inventor 尹学博徐阳韦晓密
Owner NANKAI UNIV
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